Surface modification method and structure for improving hemocompatibility of biomedical metallic substrates
AssigneeNational Chung Hsing University
InventorsShu-Ping Lin, Pei-Chieh Wong
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Abstract
The present invention relates to a surface modification method for improving the hemocompatibility of biomedical metallic substrate, comprising: fixing a sulfur-containing monomolecular film on the surface of oxide layer of a biomedical metallic substrate by molecular self-assembly. The surface modification will improve the hydrophilicity and hemocompatibility of the biomedical metallic substrate in contact with the blood, and ensure that the biomedical metallic substrate is non-toxic to the endothelial cells.
Claims12
A surface modified structure of biomedical metallic substrate for improving hemocompatibility, comprising:
- a silanol-oxide layer formed on a surface of a biomedical metallic substrate, and
- a sulfur-containing monomolecular film with exposed sulfur-containing functional groups formed on the surface of the silanol-oxide layer.
A surface modification method for improving hemocompatibility of biomedical metallic substrate, comprising:
- forming a nitric oxide (NO) layer on the surface of an oxide layer of a biomedical metallic substrate,
- and forming a sulfur-containing monomolecular film on the surface of the nitric oxide (NO) layer by means of molecular self-assembly.
Dependencies are inferred from the claim text.