Inhibitors of creatine transport and uses thereof

A compound having the structure:

• wherein Q1 is optionally substituted amidino;
• m is 1 or 2;
• R7 is hydrogen, optionally substituted C1-C6 alkyl, or optionally substituted C6-C10 aryl C1-C6 alkyl;
• R8 and R9 are independently hydrogen, deuterium, halo, hydroxyl, NH2, optionally substituted C1-C3 alkyl, or R8 and R9 combine with the atoms to which they are attached to form an optionally substituted C3-C6 cycloalkyl ring;
• or R8 or R9 combine with R10 or R11 with the atoms to which they are attached to form an optionally substituted C3-C4 cycloalkyl ring;
• or R8 or R9 combine with R12 with the atoms to which they are attached to form an optionally substituted C3-C5 heterocycle;
• R10 and R11 are independently hydrogen, deuterium, optionally substituted C1-C4 alkyl, optionally substituted C2-C6 alkenyl, optionally substituted C2-C6 alkynyl or R10 and R11 combine with the atoms to which they are attached to form an optionally substituted C3-C6 cycloalkyl ring;
• or R10 or R11 combine with R8 or R9 with the atoms to which they are attached to form an optionally substituted C3-C4 cycloalkyl ring;
• or R10 or R11 combine with R12 with the atoms to which they are attached to form an optionally substituted C3-C4 heterocycle;
• R12 is hydrogen, optionally substituted C1-C6 alkyl, or R12 combines with R8 or R9 with the atoms to which they are attached to form an optionally substituted C3-C5 heterocycle, or R12 combines with R10 or R11 with the atoms to which they are attached to form an optionally substituted C3-C4 heterocycle
• wherein if m is 1 and R8 is hydrogen, halo, hydroxyl, or methyl then at least one of R9, R10, and R11 is not hydrogen;
• wherein if m is 1 and R10 is methyl then at least one of R8, R9, and R11 is not hydrogen;
• wherein if m is 1 and R8 is NH2 and R10 is hydrogen, methyl, or —CH2CH2OH then at least one of R9 or R11 is not hydrogen;
• wherein if m is 1, R8 is halo, and R10 is optionally substituted C1-C4 alkyl then at least one of R9 and R10 is not hydrogen;
• or a pharmaceutically acceptable salt thereof.