Bioengineered Allogeneic Blood Vessel
AssigneeNovahep AB
InventorsSuchitra Sumitran-Holgersson, Michael Olausson
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Abstract
The present invention relates to methods for recellurization of blood vessels. This method is particularly useful for producing an allogeneic vein, wherein a donor vein is decellularized and then recellularized using whole blood or bone marrow stem cells. The allogeneic veins produced by the methods disclosed herein are particularly advantageous for implantation or transplantation into patients with vascular diseases.
Claims30
A method of preparing a vascular graft comprising introducing whole blood comprising progenitor cells for endothelial or smooth muscle cells to the lumen of a tubular acellular scaffold and culturing said cells, wherein the cultured cells populate the scaffold, thereby preparing the vascular graft.
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A method of treating a vascular disease or disorder in a subject in need thereof, comprising providing a vascular graft to the subject, wherein the vascular graft is prepared by a method comprising
- a. introducing subject-derived whole blood comprising progenitor cells for endothelial or smooth muscle cells to the lumen of a tubular acellular scaffold;
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- b. culturing said cells on the lumen of the tubular acellular scaffold, thereby preparing the vascular graft;
- wherein the vascular graft is transplanted to the subject for treating the vascular disease or disorder.
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Dependencies are inferred from the claim text.