High concentration antibody and protein formulations
AssigneesGenentech, Inc., Novartis AG
InventorsJun LIU, Steven J. SHIRE
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Abstract
The present application relates to highly concentrated antibody and protein formulations with reduced viscosity that are stable, relatively isotonic and are of low turbidity. The formulations are particularly suitable for subcutaneous administration. The application further describes articles of manufacture containing such formulations and method for using them to treat disorders treatable by the formulated antibody or protein.
Claims19
-50. (canceled)
A stable, liquid formulation of low turbidity comprising (a) an antibody in an amount of about 100 to about 260 mg/ml, (b) arginine HCl in an amount of about 50 to about 200 mM, and (c) histidine in an amount of about 10 to about 100 mM, and wherein the formulation further has a pH of about 5.5 to about 7.0.
Dependencies are inferred from the claim text.