Stabilization of cytochrome p450 reductase
AssigneeDsm IP Assets B.V.
InventorsAnita EMMERSTORFER, Tamara WRIESSNEGGER, Miriam WIMMER-TEUBENBACHER, Harald PICHLER, Monika MUELLER, Iwona KALUZNA, Martin SCHURMANN
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Abstract
The present invention relates to a recombinant microorganism which is capable of expressing a cytochrome P450 reductase (CPR) and, optionally, a cytochrome P450 enzyme (CYP) and which is capable of overexpressing a Ice2p comprising the amino acid sequence set out in SEQ ID NO: 2 or a sequence having at least 50% sequence identity thereto. The invention further relates to use of Ice2p to stabilize expression of a cytochrome P450 reductase in a recombinant microorganism.
Claims12
A recombinant host cell which is capable of expressing a cytochrome P450 enzyme (CYP) and a cytochrome P450 reductase (CPR) and which is capable of overexpressing a Ice2p comprising the amino acid sequence set out in SEQ ID NO:
- 2 or a sequence having at least 50% sequence identity thereto.
A product that is used to stabilize expression of a cytochrome P450 reductase in a recombinant host cell comprising Ice2p.
Dependencies are inferred from the claim text.