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US 2017/0044555 A1Published application
Recombinant rna particles and methods of producing proteins
AssigneeSynthetic Genomics, Inc.
InventorsRobert C. Brown, Kurt I. Kamrud
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AssigneeSynthetic Genomics, Inc.
InventorsRobert C. Brown, Kurt I. Kamrud
Estimating the term…
The present invention provides compositions and methods for the production and delivery of recombinant double-stranded RNA molecules (dsRNA) encoding heterologous proteins, which can be useful for various therapeutic purposes as well as for the production of desired proteins. The compositions contain engineered double-stranded RNA particles (dsRPs) that can contain a double-stranded RNA molecule that can be a genome or portion of a genome, which can be enclosed in a capsid or coat protein. The dsRNA molecule also comprises an RNA sub-sequence that encodes a heterologous protein. The dsRPs can be derived from wild-type viral organisms. The delivery of the dsRPs (or DNA or RNA molecules) of the invention to an organism provides for therapeutic benefits as well as for the production of desired proteins.
A double-stranded RNA particle (dsRP) comprising
A method of producing a protein product in a host cell comprising:
A DNA vector comprising a sequence coding for a recombinant double-stranded RNA molecule (dsRNA), wherein the RNA molecule codes for an RNA-dependent RNA polymerase and a polyprotein that forms at least part of a capsid or coat protein, and the RNA molecule further encoding a functional protein.
An RNA molecule translatable by a host cell and encoding an RNA-dependent RNA polymerase and a polyprotein that forms at least part of a capsid or coat protein of a dsRP, the RNA molecule further comprising at least one sub-sequence that encodes an additional protein product, the RNA molecule translatable by cellular components of the host cell.
A method of producing a protein product in a host cell comprising:
Dependencies are inferred from the claim text.