Novel anti-dpep3 antibodies and methods of use
AssigneeAbbvie Stemcentrx LLC
InventorsLAURA SAUNDERS, DEEPTI ROKKAM, DAVID LIU, MANDY BOONTANRART
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Abstract
Provided herein are novel anti-DPEP3 antibodies and antibody drug conjugates (ADC), including derivatives thereof, and methods of using the same to treat proliferative disorders.
Claims31
1-38. (canceled)
A monoclonal antibody that specifically binds to an epitope in human dipeptidase 3 (DPEP3) protein, wherein the monoclonal antibody is a chimeric, CDR-grafted or humanized antibody;
- or an immunoreactive fragment thereof.
A monoclonal antibody that competes for binding to human dipeptidase 3 (DPEP3) with an antibody comprising a light chain variable region sequence set forth as SEQ ID NO:
- 89 and a heavy chain variable region sequence set forth as SEQ ID NO:
- 91.
A monoclonal antibody that specifically binds to an epitope in human dipeptidase 3 (DPEP3) protein, wherein the epitope comprises three or more residues selected from the group consisting of Q248, S380, S384, and V386 of SEQ ID NO:
- 3.
A monoclonal antibody comprising three complementarity-determining regions (CDRs) of a light chain variable region set forth as SEQ ID NO:
- 205 (CDRL1, CDRL2 and CDRL3), and three CDRs of a heavy chain variable region set forth as SEQ ID NO:
- 207 (CDRH1, CDRH2 and CDRH3).
Dependencies are inferred from the claim text.