Mmp-8 activation product, its determination and use
AssigneesOy Medix Biochemica AB, Dentognostics GmbH
InventorsTimo SORSA, Dirk-Rolf GIESELMANN, Armi KORVUO, Kurt MAIER, Päivi MÄNTYLÄ, Ismo RÅMAN, Sinikka TIISALA
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Abstract
MMP-8 activation products are disclosed that have a MMP-8 middle-part activation product having a size between 20-35 kDa. Methods of detecting the MMP-8 activation product or activated MMP-8 fragments in a biological sample derived from a subject are also disclosed. The MMP-8 activation product or activated MMP-8 fragments diagnose diseases based on abnormal or elevated levels of activated MMP-8.
Claims19
A MMP-8 activation product characterized in that the MMP-8 activation product, preferably a MMP-8 middle-part activation product, comprises one or more activation fragments of MMP-8 and has a size between 20-35 kDa, preferably about 20 kDa, 25 kDa, 30 kDa or 35 kDa.
A method of determining MMP-8 activation in a sample which method comprises
- a) providing a biological sample from a subject;
- b) detecting the presence of one or more MMP-8 activation product, preferably MMP-8 middle-part activation product, comprising one or more activation fragments of MMP-8 and having a size between 5-35 kDa, preferably 10-30 kDa, more preferably about 10 kDa, 15 kDa, 20 kDa, 25 kDa, 30 kDa or 35 kDa in the biological sample;
- c) optionally correlating the presence of the MMP-8 activation product with the presence of active MMP-8 in the sample;
- and/or
- d) optionally correlating the presence of the MMP-8 activation product with the presence of other larger parts of active MMP-8 in the sample;
- wherein the presence of the MMP-8 activation product in the biological sample is indicative, confirmative and/or predictive for the presence of active MMP-8 in the sample.
Dependencies are inferred from the claim text.