Methods and materials for reducing the severity of viral infections
AssigneeMayo Foundation for Medical Education and Research
InventorsMoses Rodriguez, Allan J. Bieber, Arthur E. Warrington, Jr., Meghan McGee Painter, Eric M. Poeschla
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Abstract
This document relates to methods and materials involved in treating and/or preventing and/or reducing the severity of a viral infection present in a mammal. For example, methods and materials for reducing the severity of a viral infection present in a mammal (e.g., a human) are provided.
Claims10
1-13. (canceled)
A method for increasing expression of an Isg15 polypeptide within a mammal, wherein said method comprises administering nucleic acid encoding a picornavirus 3Dpol polypeptide or a catalytically active fragment thereof to said mammal under conditions wherein expression of said Isg15 polypeptide is increased, wherein said mammal is a mouse, dog, cat, cow, horse, or human.
The method of claim 1, wherein said administering comprises an oral administration.
Dependencies are inferred from the claim text.