Methods of sensing cross-frequency coupling and neuromodulation
OwnerDirk De Ridderinventor
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Abstract
Representative embodiments are directed to detecting neurological activity in a patient. The detection of neurological activity includes identifying cross-frequency coupling and determining whether the cross-frequency coupling is physiological or pathological. When pathological cross-frequency coupling is detected, neurostimulation of one or more sites is applied. In some embodiments, an implantable pulse generator is adapted to analyze neural activity for pathological cross-frequency coupling and to provide electrical stimulation in response to the detected pathological cross-frequency coupling.
Claims19
A method of treating a neurological disorder in a patient, comprising:
- measuring neuronal activity using one or more sensors implanted in or adjacent to the brain of the patient;
- detecting cross-frequency coupling in the measured neuronal activity, wherein the detecting cross-frequency coupling comprises determining a frequency of a lower frequency carrier component of the neuronal activity exhibiting cross-frequency coupling to a higher frequency information processing component of the neural activity;
- determining whether the determined frequency of the lower frequency carrier component is associated with a pathological condition of the neurological disorder;
- and
- applying electrical stimulation to one or more sites in the brain of the patient in response to the determining identifying the determined frequency is associated with the pathological condition of the neurological disorder.
A method of treating a neurological disorder in a patient, comprising:
- measuring neuronal activity at two separate neural sites in the brain of the patient;
- detecting cross-frequency coupling in the measured neuronal activity of the two separate neural sites, wherein the detecting cross-frequency coupling comprises identifying a frequency component of the cross-frequency coupling in a pathological frequency range;
- applying electrical stimulation to one or more sites in the brain of the patient in response to identifying the frequency component of the cross-frequency coupling in the pathological frequency range.
A system for applying electrical stimulation to one or more locations with a brain of a patient, the system comprising:
- one or more stimulation leads for applying electrical stimulation pulses to tissue and for sensing neural activity;
- an implantable pulse generator for detecting neural activity using the one or more stimulation leads and for generating electrical pulses for application to neural tissue of the patient using the one or more stimulation leads, wherein the implantable pulse generator is adapted to detect cross-frequency coupling in sensed neuronal activity of two separate neural sites, to identify a frequency component of the cross-frequency coupling in a pathological frequency range, and to apply electrical pulses to one or more sites in the brain of the patient in response to identifying the frequency component of the cross-frequency coupling in the pathological frequency range.
Dependencies are inferred from the claim text.