Neurogenic regulation of bone growth and bone degradation
AssigneeThe Research Foundation for The State University of New York
InventorsBryan S. MARGULIES, Sean D. DEBOYACE
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Abstract
This disclosure relates to methods for promoting bone formation or reducing bone destruction. This disclosure also relates to methods for promoting the recruitment of mesenchymal stem cells (MSCs) to a local site of injury or surgical intervention in bone to promote healing. In addition, this disclosure relates to methods for reducing or preventing mineral formation or bone growth, or reducing bone mass. The methods disclosed herein are useful for treating conditions such as osteopetrosis or osteoradionecrosis.
Claims24
-10. (canceled)
A method of treatment of orthopedic injuries or surgical interventions, comprising administering at least one polypeptide selected from the group consisting of netrin-1, netrin-4, slit1, slit2, slit3, RGMa, and RGMb.
A method for promoting the recruitment of mesenchymal stem cells (MSCs) to a local site of injury or surgical intervention in bone to promote healing, comprising administering an amount of at least one polypeptide selected from the group consisting of netrin-1, netrin-4, slit1, and slit2, effective to promote bone formation while inhibiting bone degradation.
A method for reducing or preventing mineral formation or bone growth, or reducing bone mass, comprising administering an amount of at least one polypeptide selected from the group consisting of RGMa, RGMb and slit3 effective to reduce or prevent mineral formation or bone growth or reduce bone mass.
An implant for promoting controlled bone growth, comprising at least one polypeptide selected from the group consisting of netrin-1, netrin-4, slit1, slit2, slit3, RGMa and RGMb, combined with nano-particles or a collagen based carrier selected from the group consisting of a collagen sponge, a powdered collagen, and a collagen based gelatin hydrogel.
Dependencies are inferred from the claim text.