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US 2017/0000913 A1Published application
Nuclear Medicine Diagnostic Imaging Agent
AssigneesKyoto University, ARKRAY, Inc.
InventorsHideo Saji, Hiroyuki Kimura, Anna Miyazaki, Hirokazu Matsuda, Shuichi Nakanishi
Life of this patent
Estimating the term…
Abstract
Provided is a radioactive labeled compound capable of detecting a secondary mutation of an epidermal growth factor receptor, where the compound is represented by Formula (1) or a pharmaceutically acceptable salt thereof, where R1, R2, and Y are as defined.
Claims18
A compound represented by Formula (1) or a pharmaceutically acceptable salt thereof:
- wherein R1 is a group represented by Formula (a), (b) or (c):
- R2 is a group represented by Formula (d) or (e):
- and
- Y is —NH— or —O—,
- wherein in Formulae (a) and (b), L1 is a bond, an alkanediyl group having 1 to 10 carbon atoms, or
- wherein 1 is 0 to 5, and m is 1 to 5,
- in Formulae (b) and (c), n is an integer of 1 to 3,
- in Formulae (a), (b) and (c), X1 is a radioactive halogen atom or —[11C]CH3,
- in Formula (d), R3 is an alkyl group having 1 to 4 carbon atoms optionally substituted with halogen, a hydroxyalkyl group having 1 to 4 carbon atoms, or an alkoxyalkyl group having 1 to 4 carbon atoms, and
- in Formulae (d) and (e), R4 is a hydrogen atom or a halogen atom.
7 more elements
A compound represented by Formula (2) or a pharmaceutically acceptable salt thereof:
- wherein R11 is a group represented by Formula (f) or (g):
- R12 is a group represented by Formula (h) or (i):
- and
- Y is —NH— or —O—,
- wherein in Formulae (f) and (g), R15 is a hydrogen atom or -L11-X11, wherein L11 is an alkanediyl group having 1 to 10 carbon atoms, or
- wherein 1 is 0 to 5, and m is 1 to 5, and X11 is a chlorine atom, a bromine atom, an iodine atom, a nitro group, a tosylate group, a mesylate group, a triflate group, a nosylate group or a brosylate group,
- in Formula (g), n is an integer of 1 to 3,
- in Formula (h), R13 is an alkyl group having 1 to 4 carbon atoms optionally substituted with halogen, a hydroxyalkyl group having 1 to 4 carbon atoms, or an alkoxyalkyl group having 1 to 4 carbon atoms, and
- in Formulae (h) and (i), R14 is a hydrogen atom or a halogen atom.
6 more elements
A compound represented by Formula (3) or a pharmaceutically acceptable salt thereof:
- wherein R21 is a group represented by Formula (j), (k) or (l):
- R22 is a group represented by Formula (m) or (n):
- and
- Y is —NH— or —O—,
- wherein in Formulae (j) and (k), L21 is a bond, an alkanediyl group having 1 to 10 carbon atoms, or
- wherein l is 0 to 5, and m is 1 to 5,
- in Formulae (k) and (l), n is an integer of 1 to 3,
- in Formulae (j), (k) and (l), X21 is a halogen atom,
- in Formula (m), R23 is an alkyl group having 1 to 4 carbon atoms optionally substituted with halogen, a hydroxyalkyl group having 1 to 4 carbon atoms, or an alkoxyalkyl group having 1 to 4 carbon atoms, and
- in Formulae (m) and (n), R24 is a hydrogen atom or a halogen atom.
7 more elements
Dependencies are inferred from the claim text.