System and method of measuring efficacy of cancer therapeutics

A method of measuring efficacy of a first therapeutic treatment for the treatment of a first neoplasm type comprising:

• placing in a vivarium a first set of animals in one or more cages;
• identifying a set of negative baseline behaviors, wherein the set of negative baseline behaviors is consistent with the first set of animals having received no injection of cells of the first neoplasm type and having received no first therapeutic treatment;
• placing cells of the first neoplasm type at a first location in a first organ of each animal (a “subject animal”) in a first subset of the first set of animals;
• wherein the first location in the first organ is associated with a first known set of animal behaviors;
• identifying a set of positive baseline behaviors wherein the set of positive baseline behaviors are consistent with the unhealthy functioning of the first location of the first organ of the first set of animals;
• treating the first subset of animals with the first therapeutic treatment;
• collecting, measuring and timing one or more behaviors of the first subset of animals, the “treatment behaviors”, wherein such collecting, measuring and timing is automated and is free of manual, human input;
• comparing the treatment behaviors to both the set of negative baseline behaviors and the set of positive baseline behaviors;
• measuring quantitatively the difference between the treatment behaviors and the set of negative baseline behaviors, and measuring quantitatively the difference between the treatment behaviors and the set of positive baseline behaviors;
• wherein the efficacy of the first therapeutic treatment is a combination of (the least difference between the treatment behaviors and the set of negative baseline behaviors) and (the largest difference between the treatment behaviors and the set of positive baseline behaviors).