Egfr-targeted nanoparticles
AssigneeCalifornia Institute of Technology
InventorMark E. DAVIS
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Abstract
Described herein are carrier nanoparticles comprising a polymer containing a polyol coupled via a boronic ester to a polymer containing a boronic acid, configured to present the polymer containing a boronic acid to an environment external to the nanoparticle. EGFR-targeted versions of the described nanoparticles are also described, as are related compositions, methods and systems.
Claims24
A targeted nanoparticle comprising a mucic acid-containing polymer, a therapeutic agent, a polymer conjugated to the mucic acid-containing polymer by a phenylboronic ester, said phenylboronic ester being coupled to the mucic acid polymer with a reversible covalent linkage, said targeted nanoparticle being configured to present the conjugated polymer to an environment external to the nanoparticle, wherein the conjugated polymer is also conjugated to a targeting ligand specific for the epidermal growth factor receptor (EGFR) at its terminal end opposite the mucic acid-containing polymer.
A method of producing a targeted nanoparticle comprising conjugating a nanoparticle comprising a mucic acid-containing polymer with a polymer containing a boronic acid and conjugating the polymer conjugated to the mucic acid-containing polymer to a targeting ligand specific for EGFR at its terminal end opposite the polymer containing a polyol, wherein the targeted nanoparticle has a ratio of the nanoparticle to the targeting ligand of no more than 1 to 1.
A kit for producing a targeted nanoparticle comprising a nanoparticle comprising a mucic acid-containing polymer, a polymer containing a boronic acid, a targeting ligand, and instructions for producing a targeted nanoparticle having a nanoparticle to targeting ligand ratio of no more than 1 to 1.
Dependencies are inferred from the claim text.