Back to results
US 2017/0000894 A1Published application
Compositions and methods for modifying the surface of cells and methods of use
AssigneeUniversity of Utah Research Foundation
InventorsYoung-Wook WON, David A. BULL, Amit N. PATEL
Life of this patent
Estimating the term…
Abstract
Described herein are compounds, compositions and methods for modification of the surface of a living cell with a therapeutically relevant targeting moiety. Also described herein are methods for treating disease states, such as acute myocardial ischemia or infarction, with said compositions, in a subject.
Claims30
A composition comprising the compound of formula (I)
- L-Y-X-T (I)
- wherein
- L is a phospholipid;
- Y is a poly(ethylene glycol);
- X is a linker derived from a reactive functional group;
- and
- T is a targeting moiety adapted to bind to a target ligand.
4 more elements
A method of localizing a cell to a location having associated therewith a target ligand, the method comprising delivering to the location a composition comprising the cell bound to the compound of formula (I):
- L-Y-X-T (I)
- wherein
- L is a phospholipid;
- Y is a poly(ethylene glycol);
- X is a linker derived from a reactive functional group;
- and
- T is a targeting moiety adapted to bind to the target ligand.
4 more elements
Dependencies are inferred from the claim text.