US 2017/0000887 A1 · UNIFORM CORE-SHELL TIO2 COATED UPCONVERSION NANOPARTICLES AND USE THEREOF

Abstract

An upconversion nanoparticle (UCN) coated with a layer of semiconductor material is disclosed. The UCN core acts as a nanotransducer to convert near infrared (NIR) to visible and/or ultraviolet (UV) light while the semiconductor shell serves as a photocatalyst. Upon excitation by NIR light, the UCN upconverts NIR light to UV and/or visible light of different wavelengths. Spectral overlap between the emitted UV and absorption wavelength of the coated TiO2 activates the TiO2 layer to generate cytotoxic reactive oxygen species (ROS), which can be used in photodynamic therapy for the treatment of cancer cells. Stability and uptake of the nanoparticles can be increased by altering the coating of the nanoparticle, such as by a polymer and a dispersion stabilizer.

Claims18

Dependent claims

A nanocomposite for photodynamic therapy, comprising:

an upconversion nanoparticle, wherein the nanoparticle, upon excitation by near infrared light, emits light of a wavelength from about 330 nm to about 675 nm;
and
a continuous and uniform outer coating on the outer surface of the nanoparticle, the coating comprising a semiconductor material, wherein the light emitted from the nanoparticle is of a wavelength sufficient to excite one or more electrons from a valence band of the semiconductor material to the conduction band of the semiconductor material, and the semiconductor material, after excitation, is of an energy sufficient to generate at least one reactive oxygen species.

Dependencies are inferred from the claim text.

Facts

Application

15/105,834Filed 30 Dec 2014

Priority

6 Jan 2014

Published

5 Jan 2017

Term ends

Not estimatedThe source records don’t support an estimate.

Classification19 codes

A61K 41/008
Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or…:…
A61K 9/5115
Excipients; Inactive ingredients: inorganic compounds
A61K 33/244
Heavy metals; Compounds thereof: lanthanides; Compounds thereof
A61K 41/0057
Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations: photodynamic…

Uniform core-shell tio2 coated upconversion nanoparticles and use thereof

Life of this patent

Uniform core-shell tio2 coated upconversion nanoparticles and use thereof

Life of this patent

Abstract

Claims18