Constrained immunogenic compositions and uses therefor
AssigneeMonash University
InventorsFasseli Joseph COULIBALY, Ashley Scott MANSELL, Rosemary Ann FFRENCH
Life of this patent
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Abstract
A stable immunogenic or vaccine composition comprising a complex or polyhedra comprising same comprising an antigen of a pathogen or other antigen against which a immune response is sought in a human or non-human animal subject and a polyhedrin protein derived from a cytoplasmic polyhedrosis virus (CPV). Delivery of the complex to a subject in substantially polyhedral form induces an immune response thereto. Methods of using same to elicit an immune response.
Claims14
1-11. canceled
A method for eliciting an immune response in a subject or patient, the method comprising administering to the subject or patient an effective amount of a pharmaceutical composition under conditions to elicit an immune response, wherein:
- the pharmaceutical composition comprises a complex in an amount that induces an immune response in a subject;
- and
- the complex comprises:
- an antigen of a pathogen or other antigen against which an immune response is sought in a human or non-human animal subject;
- and
- a polyhedrin protein derived from a cytoplasmic polyhedrosis virus (CPV), whereby delivery of the complex to a subject in substantially particulate polyhedral form induces an immune response thereto.
A method for immunizing a subject against infection or disease or a condition associated with an antigen, comprising administering to the subject a pharmaceutical composition, wherein:
- the pharmaceutical composition comprises a complex in an amount that induces an immune response in a subject;
- and
- the complex comprises:
- an antigen of a pathogen or other antigen against which an immune response is sought in a human or non-human animal subject;
- and
- a polyhedrin protein derived from a cytoplasmic polyhedrosis virus (CPV), whereby delivery of the complex to a subject in substantially particulate polyhedral form induces an immune response thereto.
A method for treating or preventing infection by a pathogen or a cancer or other condition, comprising administering to the subject a pharmaceutical composition for a time and under conditions sufficient to treat or prevent the infection or cancer or disease or condition, wherein:
- the pharmaceutical composition comprises a complex in an amount that induces an immune response in a subject;
- and
- the complex comprises:
- an antigen of a pathogen or other antigen against which an immune response is sought in a human or non-human animal subject;
- and
- a polyhedrin protein derived from a cytoplasmic polyhedrosis virus (CPV), whereby delivery of the complex to a subject in substantially particulate polyhedral form induces an immune response thereto.
A method for producing an isolated or purified antibody or immune cell that specifically binds to an antigen of a pathogen or other antigen against which a immune response is sought in a human or non-human animal subject or patient, comprising administering to a subject an effective amount of a pharmaceutical composition, and isolating or purifying the antibody or immune cell, wherein:
- the pharmaceutical composition comprises a complex in an amount that induces an immune response in a subject;
- and
- the complex comprises:
- an antigen of a pathogen or other antigen against which an immune response is sought in a human or non-human animal subject;
- and
- a polyhedrin protein derived from a cytoplasmic polyhedrosis virus (CPV), whereby delivery of the complex to a subject in substantially particulate polyhedral form induces an immune response thereto.
Dependencies are inferred from the claim text.