Monovalent h5 vaccine
AssigneeTemasek Life Sciences Laboratory Limited
InventorsFang HE, Hwei-Sing Jimmy KWANG, Prabakaran MOOKKAN
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Abstract
The present invention relates to a monovalent H5N1 vaccine. More specifically, the present invention relates to the development of a monovalent H5 vaccine strain using hemagglutinin (HA) engineering to elicit cross-clade protection. The present invention also relates to an epitope-chimeric H5 and to a reverse genetics (RG) influenza virus expressing the epitope-chimeric H5.
Claims34
An isolated modified H5 protein selected from the group consisting of a modified H5 protein having the amino acid sequence set forth in SEQ ID NO:6 and a modified H5 protein having the amino acid sequence set forth in SEQ ID NO:8.
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Dependencies are inferred from the claim text.