Pharmaceutical composition with improved stability containing factor vii fusion protein

Abstract

The present invention provides a pharmaceutical composition with improved stability, comprising a fusion protein comprising factor VII(FVII) and transferrin, as an active ingredient, wherein the transferrin is linked to the C-terminus of the FVII; and trehalose or glycine as a bulking agent. The composition can store FVII and a variant thereof stably at room temperature for a long period of time. Thus it can be used as a useful therapeutic agent for patients suffering from hemophilia or congenital FVII deficiency.

Dependencies are inferred from the claim text.