Ultrapure hypoallergenic solutions of sacrosidase
AssigneeQOL Medical LLC
InventorsDayton T. Reardan, Christopher Seekamp
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Abstract
One aspect provides an ultrapure, hypoallergenic sacrosidase. Another aspect provides a solution of sacrosidase in about 1:1 glycerol/water having an enzymatic activity of at least about 7500 IU/mL and a residual papain concentration that does not include an allergic reaction in a human patient when given a dose of about 2.0 mL/day.
Claims3
A protein composition consisting essentially of sacrosidase having a band volume ratio of sacrosidase to other proteins comprising papain of at least about 35:1 by SDS-PAGE of about 20 μg of said composition, wherein the primary structure of the sacrosidase is a 513 amino acid polypeptide that is glycosylated.
The protein composition of claim 5, wherein the band volume ratio is about 35-55:1.
The protein composition of claim 5 that is not produced by chromatographic purification of the sacrosidase.
Dependencies are inferred from the claim text.