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US 2017/0000859 A1Published application
Non-natural ribonuclease conjugates as cytotoxic agents
AssigneeQuintessence Biosciences, Inc.
InventorsLaura E. Strong, Peter A. Leland, Thomas Burke
Life of this patent
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Abstract
The present invention is directed toward the delivery of a toxic protein to pathogenic cells, particularly cancer cells. In preferred embodiments, the toxic protein is a ribonuclease that has been modified to make it toxic to target cells and that can be conjugated to a target cell-specific delivery vector, such as an antibody, for delivery to pathogenic cells.
Claims21
A composition comprising a non-natural human ribonuclease one (human RNase I) conjugated to a cell- or disease-specific targeting moiety, wherein said ribonuclease is configured to kill said cell or degrade pathogenic RNA.
Dependencies are inferred from the claim text.