Selective nox-1 inhibitor peptides and uses thereof
AssigneesUniversite De Bordeaux, Inserm
InventorsHamid Reza REZVANI, Frédéric MAZURIER, Alain TAIEB, L'Emira Ghida HARFOUCHE
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Abstract
The present invention relates to novel peptides, compositions and methods for the prevention and/or treatment of pathological conditions and diseases associated with NADPH oxidase 1 (Nox1) activity, and/or increased reactive oxygen species (ROS) production. The novel peptides are thus particularly useful for treating and/or preventing cancer, atherosclerosis, angiogenesis, and aging.
Claims12
1-22. (canceled)
A method of preventing and/or treating a pathological condition or disease associated with NADPH oxidase 1 (Nox1) activity and/or increased reactive oxygen species (ROS) production in a subject, comprising administering to said subject a therapeutically effective amount of a peptide having 7 to 35 amino acids and comprising the following sequence:
- X1-P-X2-X3-P-X4-R (SEQ ID NO:
- 1), wherein
- X1 is A, P or Q
- X2 is P, T, V, A, S, C, M or K
- X3 is L, I, V or A, and
- X4 is T, V, S, A or M.
Dependencies are inferred from the claim text.