Nylon-3 polymers active against clostridium difficile
AssigneesWisconsin Alumni Research Foundation, Emory University
InventorsSamuel H. Gellman, Runhui Liu, Bernard Weisblum, Shonna M. McBride
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Abstract
A method and corresponding composition to inhibit outgrowth of C. difficile spores and/or to inhibit growth of C. difficile vegetative cells in a mammal in which an amount of a nylon-3 polymer or nylon-3 copolymer or a pharmaceutically suitable salt thereof is administered to the subject.
Claims26
A pharmaceutical composition comprising an amount of a nylon-3 polymer or nylon-3 copolymer or a pharmaceutically suitable salt thereof, wherein the amount is effective to inhibit outgrowth of C. difficile spores and/or to inhibit growth of C. difficile vegetative cells.
A method of inhibiting outgrowth of C. difficile spores and/or inhibiting growth of C. difficile vegetative cells comprising contacting the spores or cells with an amount of a nylon-3 polymer or nylon-3 copolymer or a pharmaceutically suitable salt thereof, wherein the amount is effective to inhibit outgrowth of the C. difficile spores and/or to inhibit growth of the C. difficile vegetative cells.
A method of inhibiting outgrowth of C. difficile spores and/or inhibiting growth of C. difficile vegetative cells in a mammal comprising administering to the mammal an amount of a nylon-3 polymer or nylon-3 copolymer or a pharmaceutically suitable salt thereof, wherein the amount is effective to inhibit outgrowth of the C. difficile spores and/or to inhibit growth of the C. difficile vegetative cells in the mammal.
Dependencies are inferred from the claim text.