Lipid formulated dsrna targeting the pcsk9 gene

A composition comprising a nucleic acid lipid particle comprising a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a human PCSK9 gene in a cell, wherein:

• the nucleic acid lipid particle comprises a lipid formulation comprising 45-65 mol % of a cationic lipid, 5 mol % to about 10 mol %, of a non-cationic lipid, 25-40 mol % of a sterol, and 0.5-5 mol % of a PEG or PEG-modified lipid,
• the dsRNA consists of a sense strand and an antisense strand, and the sense strand comprises a first sequence and the antisense strand comprises a second sequence complementary to at least 15 contiguous nucleotides of a nucleotide sequence of a target sequence of a dsRNA found in Table 1a, Table 2a, Table 5a, Table 6, Table 7, Table 8,
• wherein the first sequence is complementary to the second sequence and wherein the dsRNA is between 15 and 30 base pairs in length.