Treatment of Neoplasia

A method for treatment of a cancer patient in need of treatment, which comprises the steps of:

• (i) delivering to said patient on day one of a treatment regime:
• (a) a 2-hour infusion of oxaliplatin (OXA) at a dose of about 60 to 80 mg/m2;
• (b) a 2-hour infusion of leucovorin (LV) at a dose of about 100 to 400 mg/m2;
• (c) followed by a bolus of 5-fluorouracil (5-FU) at a dose of about 300 to 500 mg/m2 and then an infusion of 5-FU for about 40 to 50 hours at a dose of about 2.0 to 2.6 g/m2;
• and repeating step (i), if required, then
• (ii) delivering selective internal radiation therapy (SIRT) to said patient between days 3 to 14 following either the commencement of step (i) or following the repeat of step (i);
• (iii) repeating step (i) for three cycles at an interval of one to three weeks between treatment cycles;
• then
• (iv) two weeks after the final treatment delivered in step (iii) delivering to said patient the following treatment:
• (a) a 2-hour infusion of OXA at a dose of about 80 to 100 mg/m2;
• (b) a 2-hour infusion of LV at a dose of about 100 and 400 mg/m2;
• (c) followed by a bolus of 5-FU at a dose of about 300 to 500 mg/m2 and then an infusion of 5-FU for about 40 to 50 hours at a dose of about 2.0 to 2.6 g/m2.