Carboxamide derivatives

A method of treating a disease or disorder mediated by Smurf-1 in a subject comprising:

• administering to said subject a therapeutically effective amount of a compound of formula (I):
• or a pharmaceutically acceptable salt thereof, wherein
• R1 is (C3-C6)alkyl or (C3-C6)cycloalkyl;
• R2 is methyl;
• R3 is
• R4 and R5 are independently selected from hydrogen, halo, (C3-C6)cycloalkyl, (C1-C4)alkyl, halo(C1-C4)alkyl, (C1-C4)alkoxy, halo(C1-C4)alkoxy or —(C1-C2)alkyl(C1-C2)alkoxy;
• or
• R2 and R4 may be taken together with the carbon atoms to which they are attached to form an azepine ring and R5 is H;
• R6 is halo, (C3-C6)cycloalkyl, (C1-C4)alkyl, halo(C1-C4)alkyl, (C1-C4)alkoxy, halo(C1-C4)alkoxy or —(C1-C2)alkyl(C1-C2)alkoxy;
• OR
• R1 is 2-fluorophenyl;
• R2 is methyl;
• and
• R3 is phenyl, substituted with one or two substituents independently selected from chloro and cyclopropyl.