Triptan powders for pulmonary delivery
AssigneeCivitas Therapeutics, Inc.
InventorMichael M. Lipp
Life of this patent
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Abstract
The invention provides stable, spray-dried, particle formulations containing a triptan, preferably sumatriptan, or a pharmaceutically acceptable salt thereof, which are useful for pulmonary administration to the respiratory tract of a patient for the treatment of disease.
Claims23
A pharmaceutical composition for pulmonary delivery to the respiratory tract of a patient comprising spray-dried particles of a triptan or a pharmaceutically salt thereof and a pharmaceutically acceptable excipient.
A powder formulation for pulmonary delivery to the respiratory tract of a patient, said powder comprising particles having a composition selected from the table below, as measured by weight percent of dry solids in the powder:
- Sumatriptan
- Sodium
- Succinate
- DPPC
- Chloride
- l-leucine
- Sugar/Sugar alcohol
- 25%
- 18%
- 2%
- 55%
- 0
- 50%
- 18%
- 2%
- 30%
- 0
- 50%
- 18%
- 2%
- 0
- 30% maltodextrin
- 50%
- 18%
- 2%
- 0
- 30% lactose
- 50%
- 18%
- 2%
- 0
- 30% mannitol
- 50%
- 18%
- 2%
- 0
- 30% trehalose
- 25%
- 18%
- 2%
- 0
- 55% trehalose
A powder formulation for pulmonary delivery to the respiratory tract of a patient, said powder comprising particles having a composition selected from the table below, as measured by weight percent of dry solids in the powder:
- Sumatriptan
- Sodium
- Free base
- DPPC
- Chloride
- Amino Acid
- Sugar/Sugar alcohol
- 50%
- 18%
- 2%
- 30% leucine
- 0
- 50%
- 18%
- 2%
- 0
- 30% maltodextrin
- 50%
- 18%
- 2%
- 0
- 30% lactose
- 50%
- 18%
- 2%
- 30% glycine
- 0
Dependencies are inferred from the claim text.