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US 2017/0000764 A1Published application
Pharmaceutical composition with improved bioavailability
AssigneeHoffmann-La Roche Inc.
InventorsSteve Lomuscio, Hua Ma, Michael Allen Matchett, Harpreet K. Sandhu, Navnit Hargovindas Shah, Yu-E Zhang
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Abstract
The invention relates to solid dispersions of poorly water soluble compounds, in particular Compound A as disclosed herein, formed by solvent co-precipitation or spray drying, resulting in improved bioavailability, safety and tolerability of said compounds.
Claims51
A physically stable solid dispersion comprising:
- a compound having an aqueous solubility of less than 1 μg/ml and a melting point of >270° C. together with a stabilizing polymer.
A method for preparing a solid dispersion of a compound having an aqueous solubility of less than 1 μg/ml and an ionic polymer which comprises:
- forming a solution of the compound and the polymer in dimethyl-acetamide, or any other suitable solvent and co-precipitating the drug with the polymer using anti-solvent.
Dependencies are inferred from the claim text.