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US 2017/0000740 A9Published application
Combination therapeutic nanoparticles
AssigneeUniversity of Georgia Research Foundation, Inc.
InventorsShanta Dhar, Rakesh Kumar Pathak
Life of this patent
Estimating the term…
Abstract
Nanoparticles that include a chemotherapeutic agent and an anti-inflammatory are particularly cytotoxic to prostate cancer cells.
Claims23
1-7. (canceled)
A method for treating prostate cancer in a subject in need thereof, comprising:
- administering a therapeutically effective amount of a nanoparticle comprising a chemotherapeutic agent and an anti-inflammatory agent to the subject.
A nanoparticle, comprising:
- a hydrophobic nanoparticle core, wherein the hydrophobic polymer that forms at least a part of the core is selected from the group consisting of a polymer comprising polylactic acid (PLA) and a polymer comprising polylactic-co-glycolic acid (PLGA);
- a hydrophilic layer surrounding the core, wherein the hydrophilic polymer moiety is attached to the core via a hydrophobic polymer moiety that forms at least a part of the core;
- an anti-inflammatory agent attached to the core;
- and
- a chemotherapeutic agent attached to the core.
2 more elements
(canceled)
A nanoparticle, comprising:
- a hydrophobic nanoparticle core, wherein the hydrophobic polymer that forms at least a part of the core is selected from the group consisting of a polymer comprising polylactic acid (PLA) and a polymer comprising polylactic-co-glycolic acid (PLGA);
- a hydrophilic layer surrounding the core, wherein the hydrophilic polymer moiety is attached to the core via a hydrophobic polymer moiety that forms at least a part of the core;
- an inhibitor of bone resorption attached to the core;
- and
- a chemotherapeutic agent attached to the core.
2 more elements
A compound selected from the group consisting of:
Dependencies are inferred from the claim text.