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AssigneeNova Southeastern University
InventorsMutasem RAWAS-QALAJI, Ousama RACHID, Keith SIMONS, Estelle SIMONS
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The invention provides compositions including epinephrine nanoparticles and methods for therapeutic use of the compositions in the treatment of conditions responsive to epinephrine such as a cardiac event or an allergic reaction, particularly anaphylaxis. The epinephrine nanoparticles can be incorporated into orally-disintegrating and fast-disintegrating tablet pharmaceutical formulations and can significantly increase the sublingual bioavailability of epinephrine, and thereby reduce the epinephrine dose required. Additionally, the invention provides methods for fabrication of stabilized epinephrine nanoparticles for use in the described compositions.
Epinephrine nanoparticles comprising chitosan and tripolyphosphate (TPP).
Epinephrine nanoparticles comprising chitosan, tripolyphosphate (TPP), and a taste enhancer.
A method for fabricating epinephrine nanoparticles comprising:
A method for enhancing sublingual bioavailability of epinephrine in a subject in need thereof, comprising:
A method for treating a condition responsive to epinephrine in a subject in need thereof, comprising:
A method for treatment of a breathing difficulty in a subject in need thereof, comprising:
A method for treatment of an allergic emergency in a subject diagnosed with or suspected of having an allergic emergency, comprising:
A method for treatment of a cardiac event in a subject diagnosed with or suspected of having a cardiac event, comprising:
An epinephrine nanoparticle encapsulated with chitosan and tripolyphosphate (TPP) and at least one of a pharmaceutically-acceptable carrier, a penetration enhancer, a mucoadhesive, a taste enhancer, and a sweetening agent and mouthfeel enhancer for use in the manufacture of a composition for enhancing sublingual bioavailability of epinephrine in a subject in need thereof.
An epinephrine nanoparticle encapsulated with chitosan and tripolyphosphate (TPP) and at least one of a pharmaceutically-acceptable carrier, a penetration enhancer, a mucoadhesive, a taste enhancer, and a sweetening agent and mouthfeel enhancer for use in the manufacture of a composition for treating a condition responsive to epinephrine in a subject in need thereof.
An epinephrine nanoparticle encapsulated with chitosan and tripolyphosphate (TPP) and at least one of a pharmaceutically-acceptable carrier, a penetration enhancer, a mucoadhesive, a taste enhancer, and a sweetening agent and mouthfeel enhancer for use in the manufacture of a composition for treating a breathing difficulty in a subject in need thereof.
An epinephrine nanoparticle encapsulated with chitosan and tripolyphosphate (TPP) and at least one of a pharmaceutically-acceptable carrier, a penetration enhancer, a mucoadhesive, a taste enhancer, and a sweetening agent and mouthfeel enhancer for use in the manufacture of a composition for treatment of an allergic emergency in a subject diagnosed with or suspected of having an allergic emergency.
An epinephrine nanoparticle encapsulated with chitosan and tripolyphosphate (TPP) and at least one of a pharmaceutically-acceptable carrier, a penetration enhancer, a mucoadhesive, a taste enhancer, and a sweetening agent and mouthfeel enhancer for use in the manufacture of a composition for treatment of a cardiac event in a subject diagnosed with or suspected of having a cardiac event.
An epinephrine nanoparticle encapsulated with chitosan and tripolyphosphate (TPP) and at least one of a pharmaceutically-acceptable carrier, a penetration enhancer, a mucoadhesive, a taste enhancer, and a sweetening agent and mouthfeel enhancer for use in the formulation of a composition for buccal or sublingual administration to a subject in need thereof.
Dependencies are inferred from the claim text.