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US 2017/0000733 A1Published application
Pharmaceutical compositions of amorphous dispersions of drugs and lipophilic microphase-forming materials
AssigneeBend Research, Inc.
InventorsMichael E. Perlman, Ravi M. Shanker, Walter C. Babcock, Dwayne Thomas Friesen, Mark D. Rabenstein, Daniel Tod Smithey
Life of this patent
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Abstract
A pharmaceutical composition comprises a solid amorphous dispersion comprising a low-solubility drug and a concentration-enhancing polymer and a lipophilic microphase-forming material. Alternatively, a solid amorphous dispersion comprising a low-solubility drug and a concentration-enhancing polymer is co-administered with a lipophilic microphase-forming material to an in vivo use environment.
Claims13
1-22. (canceled)
A composition in the form of a dosage form, comprising:
- a) a solid amorphous dispersion comprising an active pharmaceutical ingredient and a polymer;
- and
- b) an amphiphilic material dispersed in a solid excipient;
- wherein the amphiphilic material is selected from sulfonated hydrocarbons and their salts, poloxamers, polyoxyethylene alkyl ethers, polyoxyethylene sorbitan fatty acid esters, short-chain glyceryl mono-alkylates, polyglycolized glycerides, mono- and di-alkylate esters of polyols, polyethylene (40 or 60) hydrogenated castor oil, polyoxyethylene (35) castor oil, alpha tocopheryl polyethylene glycol 1000 succinate, glyceryl PEG 8 caprylate/caprate, PEG 32 glyceryl laurate, polyoxyethylene fatty acid esters, and polyoxyethylene fatty acid ethers.
1 more element
Dependencies are inferred from the claim text.