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US 2017/0000731 A1Published application
Implant device for drug delivery
AssigneeNano Precision Medical, Inc.
InventorsAdam D. Mendelsohn, Kathleen Fischer, Tomoyuki Yoshie
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Abstract
The present invention provides a method for controlling the internal diameter of nanopores to afford nanopore membranes with a zero-order rate of release of a therapeutic agent.
Claims24
A method of preparing a coated nanoporous membrane comprising a plurality of nanopores, wherein each nanopore has a first open end and an interior, the method comprising:
- forming a reaction mixture under vapor deposition conditions in a reaction chamber wherein the reaction mixture comprises a coating agent and the nanoporous membrane, such that a portion of the interior of each nanopore is coated with the coating agent to form a coating layer.
A nanopore membrane comprising:
- a plurality of nanopore, each nanopore having a first open end and an interior, wherein at least one nanopore comprises a coating layer on a portion of the interior.
A device comprising:
- a capsule suitable for implantation;
- a reservoir encapsulated by the capsule, wherein the reservoir is suitable for containing a therapeutic agent;
- and
- a nanopore membrane attached to the capsule such that the nanopore membrane is in contact with the reservoir, wherein the nanopore membrane comprises a plurality of nanopores in fluid contact with the reservoir, wherein the nanopores have an interior with a coating layer on at least a portion of the interior,
- such that the plurality of nanopores is a diffusion pathway out of the reservoir for the therapeutic agent.
2 more elements
A titania composition comprising
- a titanium substrate;
- an amorphous titania layer on the titanium substrate, wherein the titania layer comprises TiOxCy, wherein subscript x is from about 1.5 to about 4.0, and subscript y is from 0 to about 1.0;
- and
- at least one layer of TiOx chemically bound to the amorphous titania layer, wherein subscript x is from about 1.5 to about 4.0.
1 more element
Dependencies are inferred from the claim text.