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AssigneeThe Curators of the University of Missouri
InventorsMartin L. Katz, Joan R. Coates, Christopher J. Tracy, Rebecca E.H. Whiting, Jacqueline W. Pearce
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The present invention provides methods and compositions for treating a neurodegeneration disease or retinal degenerative disease in a mammal comprising the use of mesenchymal stem cells expressing a therapeutic compound. The invention also provides cells and constructs for use in such methods. Also provided are kits for treatment of a neurodegeneration disease or retinal degenerative disease. The present invention relates in general to the field of retinal degenerative and neurodegenerative diseases. More specifically, the invention relates to methods for treatment of retinal degenerative and neurodegenerative disease.
A method of treatment or prevention of a neurodegenerative disease or retinal degenerative disease comprising delivery of at least one cell to a subject, wherein said cell provides a therapeutic compound to said subject in an effective amount to reduce disease symptoms.
A construct for treating a neurodegenerative disease in a subject, the construct comprising a sequence expressing a therapeutic protein or peptide operably linked to a promoter that functions in an animal cell, wherein delivery of the construct to the subject in an effective amount reduces disease symptoms in the subject.
A composition for treating a neurodegenerative disease in a subject comprising at least one cell expressing a therapeutic protein or peptide in an effective amount to reduce disease symptoms and a carrier.
A kit for treating a neurodegenerative disease in a subject comprising at least one cell from the subject expressing a therapeutic compound for treating a neurodegenerative disease in the subject.
Dependencies are inferred from the claim text.