Controlled-Release CNS Modulating Compositions and Methods for the Treatment of Otic Disorders
AssigneesOtonomy, Inc., The Regents of the University of California
InventorsJay Lichter, Andrew M. Trammel, Fabrice Piu, Qiang Ye, Michael Christopher Scaife, Benedikt Vollrath, Sergio G. Duron, Luis A. Dellamary, Carl Lebel, Jeffrey P. Harris
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Abstract
Disclosed herein are compositions and methods for the treatment of otic disorders with CNS modulating agent compositions and compositions administered locally to an individual afflicted with an otic disorder, through direct application of these compositions and compositions onto or via perfusion into the targeted auris structure(s).
Claims18
-20. (canceled)
An intratympanic composition for use in the treatment of an otic disease or condition by administration on or near the round window membrane of the ear, the intratympanic composition comprising
- a multiparticulate Central Nervous System (CNS) modulator, or pharmaceutically acceptable salt thereof;
- and
- an auris acceptable gel,
- wherein the multiparticulate Central Nervous System (CNS) modulator, or pharmaceutically acceptable salt thereof is not provided as polymer-containing particles, and is suspended in the auris acceptable gel.
Dependencies are inferred from the claim text.