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US 2017/0000725 A1Published application
Compositions, methods & systems for respiratory delivery of two or more active agents
AssigneePearl Therapeutics, Inc.
InventorsReinhard Vehring, Michael Steven Hartman, David Lechuga-Ballesteros, Adrian Edward Smith, Vidya B. Joshi, Sarvajna Kumar Dwivedi
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Abstract
Compositions, methods and systems are provided for pulmonary or nasal delivery of two or more active agents via a metered dose inhaler. In one embodiment, the compositions include a suspension medium, active agent particles, and suspending particles, in which the active agent particles and suspending particles form a co-suspension within the suspension medium.
Claims31
-61. (canceled)
A pharmaceutical composition deliverable from a metered dose inhaler, the composition comprising:
- a suspension medium comprising a pharmaceutically acceptable propellant;
- one or more species of respirable active agent particles comprising two or more active agents;
- and
- a plurality of respirable suspending particles different than the active agent particles and comprising a particulate phospholipid material that is substantially insoluble in the suspension medium, wherein the active agent particles and suspending particles are included in the suspension medium at a weight ratio of total mass of the suspending particles to total mass of the one or more species of active agent particles that ranges from above 1:1 and up to 200:1.
1 more element
Dependencies are inferred from the claim text.