Use of Blood Flow Parameters to Monitor or Control the Dosing of Anti-Platelet Agents

A method for improving the safety and efficacy of an antiplatelet agent in a subject, the method comprising:

• measuring a whole blood viscosity of the subject to obtain a first value;
• administering an antiplatelet agent to the subject;
• measuring a whole blood viscosity of the subject to obtain a second value wherein a value of less than about 13 cP but greater than about 6 cP when measured at a low shear rate of 5 sec−1, indicates the hemorrhagic safety and thrombogenic efficacy of the antiplatelet agent for the subject;
• and administering a subsequent dose of the antiplatelet agent to the subject to attain the value of less than about 12 cP when measured at a low shear rate of 5 sec−1.

A method for improving the safety and efficacy of an antiplatelet agent in a subject, the method comprising:

• measuring a whole blood viscosity of the subject to obtain a first viscosity value;
• administering an antiplatelet agent to the subject;
• measuring a whole blood viscosity of the subject to obtain a second viscosity value;
• determining a value for a difference between the first viscosity value and the second viscosity value;
• comparing the value for the difference to a threshold value;
• targeting a whole blood viscosity value for the subject if the value of the difference has crossed the threshold value;
• and administering a subsequent dose of the antiplatelet agent to attain the targeted whole blood viscosity.