Use of biomarkers and therapeutic agents with surgical devices

An apparatus, comprising:

• (a) a handpiece;
• (b) a shaft extending distally from the handpiece, wherein the shaft includes a distal end;
• (c) a conduit extending through the shaft;
• (d) an end effector positioned at the distal end of the shaft, wherein the end effector comprises a harmonic blade, wherein the end effector is in fluid communication with the conduit;
• and
• (e) a therapeutic agent administration assembly in fluid communication with the conduit, wherein the therapeutic agent administration assembly is operable to administer a therapeutic agent through the end effector.

An apparatus, comprising:

• (a) a handpiece;
• (b) a shaft extending distally from the handpiece, wherein the shaft includes a distal end;
• (c) an end effector positioned at the distal end of the shaft;
• (d) a biomarker collection assembly in fluid communication with the end effector, wherein the biomarker collection assembly is configured to draw in biomarkers through the end effector and store or process the biomarkers;
• and
• (e) a biomarker response assembly, wherein the biomarker response assembly is operable to either:
• (i) change an operating parameter of the end effector based at least in part on biomarker data from the biomarker assembly, or
• (ii) administer a therapeutic agent through the end effector based at least in part on biomarker data from the biomarker collection assembly.