Rapid, reproducible, non-invasive predictor of cadaveric donor liver graft utilization
AssigneeThe Regents of the University of California
InventorAli Zarrinpar
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Abstract
A method for rapid, non-invasive assessment of liver function in a brain-dead donor, prior to procurement is presented. Quantitative assessment of liver function can be measured in brain-dead donors in the local donor service area prior to organ procurement by measuring indocyanine green plasma disappearance rates (ICG-PDR). This method can be performed with devices that use a non-invasive finger probe to obtain the ICG-PDR using pulse-densitometry.
Claims9
A method for determining whether liver tissue will be acceptable for transplantation, the method comprising:
- (a) measuring indocyanine green plasma disappearance rates (ICG-PDR) in a brain-dead donor prior to organ procurement;
- and
- (b) designating liver tissue in the donor as acceptable for transplantation if the ICG-PDR is greater than about 18%.
A method of determining whether liver tissue will be acceptable for transplantation, the method comprising:
- (a) measuring indocyanine green plasma disappearance rates (ICG-PDR) in a brain-dead donor prior to organ procurement;
- (b) comparing measured ICG-PDR to a threshold;
- and
- (c) designating liver tissue in the donor as acceptable for transplantation if the ICG-PDR exceeds the threshold.
Dependencies are inferred from the claim text.