System and method for imaging free radicals
AssigneeThe General Hospital Corporation
InventorsMatthew S. Rosen, Mathieu Sarracanie, Brandon Armstrong, Cenk Ayata, Fanny Herisson, Peter Caravan, Eric Gale
Life of this patent
Estimating the term…
Abstract
A system and method performing a medical imaging process includes arranging a subject to receive an exogenously administered free radical probe, performing an Overhauser-enhanced MRI (OMRI) imaging process to acquire data from the subject, and reconstructing the data to generate a report indicating a spatial distribution of free radicals in the subject.
Claims20
A magnetic resonance imaging (MRI) system configured to perform an imaging process of a subject having received an exogenously administered free radical probe, comprising:
- a magnet system configured to generate a static magnetic field about at least a region of interest (ROI) of the subject arranged in the MRI system;
- at least one gradient coil configured to establish at least one magnetic gradient field with respect to the static magnetic field;
- a radio frequency (RF) system configured to deliver excitation pulses to the subject;
- a computer system programmed to:
- control the at least one gradient coil and the RF system to perform a magnetic resonance (MR) imaging pulse sequence;
- while performing the MR pulse sequence, perform electron spin resonance (ESR) pulses;
- acquire data corresponding to signals from the subject having received an exogenously administered free radical probe excited by the MR pulse sequence and the ESR pulses;
- and
- reconstruct, from the data, at least one anatomical image of the subject and spatially distributed free radicals within the subject relative to the anatomical image.
A method for performing a medical imaging process, the method comprising:
- arranging a subject to receive an exogenously administered free radical probe;
- performing an Overhauser-enhanced magnetic resonance imaging (OMRI) process to acquire data from the subject;
- and
- reconstructing the data to generate a report indicating a spatial distribution of free radicals in the subject.
Dependencies are inferred from the claim text.