System and methods for sensing vector selection

A system for evaluating a plurality of candidate sensing vectors for use in sensing electrical activity of a heart, the system comprising:

• a sensing circuit configured to sense one or more physiologic signals indicative of target cardiac electrical activity according to a specified sensing vector involving first and second electrodes;
• a signal processor circuit, configured to generate a signal intensity indicator and an interference indicator using the one or more physiologic signals, the signal intensity indicator indicative of the strength of the sensed one or more physiologic signals, the interference indicator indicative of presence or degree of interference produced by an activity other than the target cardiac electrical activity;
• and
• a sensing vector assessment circuit, included in or communicatively coupled to the signal processor circuit, configured to:
• for the plurality of candidate sensing vectors, receive respective signal intensity indicators and respective interference indicators;
• for the plurality of candidate sensing vectors, receive respective electrode information about first and second electrodes of the corresponding candidate sensing vector, the respective electrode information including the respective first or second electrode also used for delivering cardiac electrostimulation;
• and
• produce a rankable set of at least some of the plurality of candidate sensing vectors using the respective signal intensity indicators, the respective interference indicators, and the respective electrode information.