System and method for retinopathy detection

A device providing an indication of eye disease in a patient comprising:

• a. an illumination system configured to provide an eye of the patient with at least two stimulus intervals of flashes of light that differ in at least one property, the properties selected from flash frequency, flash color, background retinal illuminance, background color, and retinal illuminance energy;
• b. a controller adapted to receive and analyze an electrical signal from the visual system of the patient from at least two intervals of flashes of light so as to provide the indication of eye disease based on that analysis;
• wherein the flash frequencies of the at least two stimulus intervals are between 4 Hz and 50 Hz;
• and
• wherein the retinal illuminance energies of the at least two stimulus intervals are within a factor of 1.2 of one of 1, 2, 4, 8, 10, 16, and 32 Td-s.

A method for providing an indication of eye disease in a patient comprising:

• illuminating an eye of the patient with a diffuse light stimulus having at least two stimulus intervals having different, nonzero, average retinal illuminances wherein at least one of the stimulus intervals has a stimulus frequency between 4 Hz and 50 Hz
• measuring the eye's pupil area and adjusting the luminance of the light as a non-constant function of the eye's pupil area;
• and
• providing an indication of eye disease based on the pupil measurements.

A method for providing an indication of eye disease in a patient comprising:

• illuminating an eye of the patient with at least two intervals of flashes of light that differ in at least one property, the properties selected from flash frequency, flash color, background retinal illuminance, background color, and retinal illuminance energy;
• receiving and analyzing an electrical signal from the visual system of the patient from each interval so as to provide an indication of eye disease based on the electrical signals;
• wherein the flash frequencies of the at least two stimulus intervals are between 4 Hz and 50 Hz;
• and
• wherein the retinal illuminance energies of the at least two stimulus intervals are within a factor of 1.2 of one of 1, 2, 4, 8, 10, 16, and 32 Td-s.