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AssigneeMontana State University—Billings
InventorsKurt A. Toenjes, David K. Butler, Joy Goffena
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A method for controlling conidial germination and mycelial growth in fungi comprising contacting a fungal cell with anti-fungal small molecules in an amount effective to reduce or inhibit conidial germination and mycelial growth. A method for controlling bark beetle infestations of pine trees comprising contacting one or more fungal cells with anti-fungal small molecules in an amount effective to reduce or inhibit conidial germination and mycelial growth. The anti-fungal small molecules are 5-(p-Bromobenzylidine)-α-isopropyl-4-oxo-2-thioxo-3-thiozolidineacetic acid, 2-[5-(4-chlorobenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]-3-methylbutanoic acid, 2-[5-(4-hydroxybenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]pentanoic acid, [5-(4-isopropylbenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid or 2-[5-(2-chlorobenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]pentanoic acid. The species of the fungal cell is selected from a group that has an obligate symbiosis with the mountain pine beetle (Dendroctonus ponderosae) and the western pine beetle (Dendroctonus brevicomis).
A method for controlling conidial germination and mycelial growth in fungi comprising contacting a fungal cell with an anti-fungal small molecule in an amount effective to reduce or inhibit conidial germination and mycelial growth, wherein the anti-fungal small molecule is 2-[5-(4-chlorobenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]-3-methylbutanoic acid, and wherein the species of the fungal cell is Grosmannia clavigera.
A method for controlling conidial germination and mycelial growth in fungi comprising contacting a fungal cell with an anti-fungal small molecule in an amount effective to reduce or inhibit conidial germination and mycelial growth, wherein the anti-fungal small molecule is 2-[5-(4-chlorobenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]-3-methylbutanoic acid, and wherein the species of the fungal cell is Ophiostoma montium.
A method for controlling conidial germination and mycelial growth in fungi comprising contacting a fungal cell with an anti-fungal small molecule in an amount effective to reduce or inhibit conidial germination and mycelial growth, wherein the anti-fungal small molecule is 2-[5-(4-chlorobenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]-3-methylbutanoic acid, and wherein the species of the fungal cell is Ceratocystiopsis brevicomi.
A method for controlling bark beetle infestations of pine trees comprising contacting one or more fungal cells with an anti-fungal small molecule in an amount effective to reduce or inhibit conidial germination and mycelial growth, wherein the anti-fungal small molecule is 2-[5-(4-chlorobenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]-3-methylbutanoic acid, and wherein the species of the fungal cell is Grosmannia clavigera.
A method for controlling bark beetle infestations of pine trees comprising contacting one or more fungal cells with an anti-fungal small molecule in an amount effective to reduce or inhibit conidial germination and mycelial growth, wherein the anti-fungal small molecule is 2-[5-(4-chlorobenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]-3-methylbutanoic acid, and wherein the species of the fungal cell is Ophiostoma montium.
A method for controlling bark beetle infestations of pine trees comprising contacting one or more fungal cells with an anti-fungal small molecule in an amount effective to reduce or inhibit conidial germination and mycelial growth, wherein the anti-fungal small molecule is 2-[5-(4-chlorobenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]-3-methylbutanoic acid, and wherein the species of the fungal cell is Ceratocystiopsis brevicomi.
A method for controlling conidial germination and mycelial growth in fungi comprising contacting a fungal cell with an anti-fungal small molecule in an amount effective to reduce or inhibit conidial germination and mycelial growth, wherein the anti-fungal small molecule is 2-[5-(4-chlorobenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]-3-methylbutanoic acid, and wherein the species of the fungal cell is selected from a group that has an obligate symbiosis with the mountain pine beetle (Dendroctonus ponderosae) and the western pine beetle (Dendroctonus bervicomis).
A method for controlling bark beetle infestations of pine trees comprising contacting one or more fungal cells with an anti-fungal small molecule in an amount effective to reduce or inhibit conidial germination and mycelial growth, wherein the anti-fungal small molecule is 2-[5-(4-chlorobenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]-3-methylbutanoic acid, and wherein the species of the fungal cell is selected from a group that has an obligate symbiosis with the mountain pine beetle (Dendroctonus ponderosae) and the western pine beetle (Dendroctonus bervicomis).
A method for controlling conidial germination and mycelial growth in fungi comprising contacting a fungal cell with an anti-fungal small molecule in an amount effective to reduce or inhibit conidial germination and mycelial growth, wherein the anti-fungal small molecule is 2-[5-(4-hydroxybenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]pentanoic acid, and wherein the species of the fungal cell is Grosmannia clavigera.
A method for controlling conidial germination and mycelial growth in fungi comprising contacting a fungal cell with an anti-fungal small molecule in an amount effective to reduce or inhibit conidial germination and mycelial growth, wherein the anti-fungal small molecule is 2-[5-(4-hydroxybenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]pentanoic acid, and wherein the species of the fungal cell is Ophiostoma montium.
A method for controlling conidial germination and mycelial growth in fungi comprising contacting a fungal cell with an anti-fungal small molecule in an amount effective to reduce or inhibit conidial germination and mycelial growth, wherein the anti-fungal small molecule is 2-[5-(4-hydroxybenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]pentanoic acid, and wherein the species of the fungal cell is Ceratocystiopsis brevicomi.
A method for controlling bark beetle infestations of pine trees comprising contacting one or more fungal cells with an anti-fungal small molecule in an amount effective to reduce or inhibit conidial germination and mycelial growth, wherein the anti-fungal small molecule is 2-[5-(4-hydroxybenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]pentanoic acid and wherein the species of the fungal cell is Grosmannia clavigera.
A method for controlling bark beetle infestations of pine trees comprising contacting one or more fungal cells with an anti-fungal small molecule in an amount effective to reduce or inhibit conidial germination and mycelial growth, wherein the anti-fungal small molecule is 2-[5-(4-hydroxybenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]pentanoic acid, and wherein the species of the fungal cell is Ophiostoma montium.
A method for controlling bark beetle infestations of pine trees comprising contacting one or more fungal cells with an anti-fungal small molecule in an amount effective to reduce or inhibit conidial germination and mycelial growth, wherein the anti-fungal small molecule is 2-[5-(4-hydroxybenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]pentanoic acid, and wherein the species of the fungal cell is Ceratocystiopsis brevicomi.
A method for controlling conidial germination and mycelial growth in fungi comprising contacting a fungal cell with an anti-fungal small molecule in an amount effective to reduce or inhibit conidial germination and mycelial growth, wherein the anti-fungal small molecule is 2-[5-(4-hydroxybenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]pentanoic acid, and wherein the spccies of the fungal cell is selected from a group that has an obligate symbiosis with the mountain pine beetle (Dendroctonus ponderosae) and the western pine beetle (Dendroctonus bervicomis).
A method for controlling bark beetle infestations of pine trees comprising contacting one or more fungal cells with an anti-fungal small molecule in an amount effective to reduce or inhibit conidial germination and mycelial growth, wherein the anti-fungal small molecule is 2-[5-(4-hydroxybenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]pentanoic acid, and wherein the species of the fungal cell is selected from a group that has an obligate symbiosis with the mountain pine beetle (Dendroctonus ponderosae) and the western pine beetle (Dendroctonus bervicomis).
A method for controlling conidial germination and mycelial growth in fungi comprising contacting a fungal cell with an anti-fungal small molecule in an amount effective to reduce or inhibit conidial germination and mycelial growth, wherein the anti-fungal small molecule is [5-(4-isopropylbenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid, and wherein the species of the fungal cell is Grosmannia clavigera.
A method for controlling conidial germination and mycelial growth in fungi comprising contacting a fungal cell with an anti-fungal small molecule in an amount effective to reduce or inhibit conidial germination and mycelial growth, wherein the anti-fungal small molecule is [5-(4-isopropylbenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid, and wherein the species of the fungal cell is Ophiostoma montium.
A method for controlling conidial germination and mycelial growth in fungi comprising contacting a fungal cell with an anti-fungal small molecule in an amount effective to reduce or inhibit conidial germination and mycelial growth, wherein the anti-fungal small molcculc is [5-(4-isupropylbenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid, and wherein the species of the fungal cell is Ceratocystiopsis brevicomi.
A method for controlling bark beetle infestations of pine trees comprising contacting one or more fungal cells with an anti-fungal small molecule in an amount effective to reduce or inhibit conidial germination and mycelial growth, wherein the anti-fungal small molecule is [5-(4-isopropylbenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid, and wherein the species of the fungal cell is Grosmannia clavigera.
A method for controlling bark beetle infestations of pine trees comprising contacting one or more fungal cells with an anti-fungal small molecule in an amount effective to reduce or inhibit conidial germination and mycelial growth, wherein the anti-fungal small molecule is [5-(4-isopropylbenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid, and wherein the species of the fungal cell is Ophiostoma montium.
A method for controlling bark beetle infestations of pine trees comprising contacting one or more fungal cells with an anti-fungal small molecule in an amount effective to reduce or inhibit conidial germination and mycelial growth, wherein the anti-fungal small molecule is [5-(4-isopropylbenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid, and wherein the species of the fungal cell is Ceratocystiopsis brevicomi.
A method for controlling conidial germination and mycelial growth in fungi comprising contacting a fungal cell with an anti-fungal small molecule in an amount effective to reduce or inhibit conidial germination and mycelial growth, wherein the anti-fungal small molecule is [5-(4-isopropylbenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid, and wherein the species of the fungal cell is selected from a group that has an obligate symbiosis with the mountain pine beetle (Dendroctonus ponderosae) and the western pine beetle (Dendroctonus bervicomis).
A method for controlling bark beetle infestations of pine trees comprising contacting one or more fungal cells with an anti-fungal small molecule in an amount effective to reduce or inhibit conidial germination and mycelial growth, wherein the anti-fungal small molecule is [5-(4-isopropylbenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid, and wherein the species of the fungal cell is selected from a group that has an obligate symbiosis with the mountain pine beetle (Dendroctonus ponderosas) and the western pine beetle (Dendroctonus bervicomis).
A method for controlling conidial germination and mycelial growth in fungi comprising contacting a fungal cell with an anti-fungal small molecule in an amount effective to reduce or inhibit conidial germination and mycelial growth, wherein the anti-fungal small molecule is 2-[5-(2-chlorobenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]pentanoic acid, and wherein the species of the fungal cell is Grosmannia clavigera.
A method for controlling conidial germination and mycelial growth in fungi comprising contacting a fungal cell with an anti-fungal small molecule in an amount effective to reduce or inhibit conidial germination and mycelial growth, wherein the anti-fungal small molecule is 2-[5-(2-chlorobenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]pentanoic acid, and wherein the species of the fungal cell is Ophiostoma montium.
A method for controlling conidial germination and mycelial growth in fungi comprising contacting a fungal cell with an anti-fungal small molecule in an amount effective to reduce or inhibit conidial germination and mycelial growth, wherein the anti-fungal small molecule is 2-[5-(2-chlorobenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]pentanoic acid, and wherein the species of the fungal cell is Ceratocystiopsis brevicomi.
A method for controlling bark beetle infestations of pine trees comprising contacting one or more fungal cells with an anti-fungal small molecule in an amount effective to reduce or inhibit conidial germination and mycelial growth, wherein the anti-fungal small molecule is 2-[5-(2-chlorobenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]pentanoic acid, and wherein the species of the fungal cell is Grosmannia clavigera.
A method for controlling bark beetle infestations of pine trees comprising contacting one or more fungal cells with an anti-fungal small molecule in an amount effective to reduce or inhibit conidial germination and mycelial growth, wherein the anti-fungal small molecule is 2-[5-(2-chlorobenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]pentanoic acid, and wherein the species of the fungal cell is Ophiostoma montium.
A method for controlling bark beetle infestations of pine trees comprising contacting one or more fungal cells with an anti-fungal small molecule in an amount effective to reduce or inhibit conidial germination and mycelial growth, wherein the anti-fungal small molecule is 2-[5-(2-chlorobenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]pentanoic acid, and wherein the species of the fungal cell is Ceratocystiopsis brevicomi.
A method for controlling conidial germination and mycelial growth in fungi comprising contacting a fungal cell with an anti-fungal small molecule in an amount effective to reduce or inhibit conidial germination and mycelial growth, wherein the anti-fungal small molecule is 2-[5-(2-chlorobenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]pentanoic acid, and wherein the species of the fungal cell is selected from a group that has an obligate symbiosis with the mountain pine beetle (Dendroctonus ponderosae) and the western pine beetle (Dendroctonus bervicomis).
A method for controlling bark beetle infestations of pine trees comprising contacting one or more fungal cells with an anti-fungal small molecule in an amount effective to reduce or inhibit conidial germination and mycelial growth, wherein the anti-fungal small molecule is 2-[5-(2-chlorobenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]pentanoic acid, and wherein the species of the fungal cell is selected from a group that has an obligate symbiosis with the mountain pine beetle (Dendroctonus ponderosae) and the western pine beetle (Dendroctonus bervicomis).
Dependencies are inferred from the claim text.