Thienopyrrole compounds and uses thereof

A method of inhibiting an Oplophorus-derived luciferase, the method comprising contacting the Oplophorus-derived luciferase with a compound of formula (II):

• wherein:
• the dashed line represents the presence or absence of a bond;
• n is 0, 1, 2, 3, 4 or 5;
• X is CH, N, O, or S;
• wherein, when the dashed line represents the presence of a bond, X is CH or N, and
• when the dashed line represents the absence of a bond, X is O or S;
• A is an optionally substituted phenyl ring, or an optionally substituted 5- or 6-membered heteroaryl ring;
• R4 and R2 are each independently selected from the group consisting of hydrogen, optionally substituted C1-C8 alkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted arylalkyl, optionally substituted alkoxyalkyl and optionally substituted alkoxyalkoxyalkyl;
• Z is selected from the group consisting of —NR3R4 and —OR5;
• and
• R3, R4 and R5 are each independently selected from the group consisting of hydrogen, optionally substituted C1-C8 alkyl, optionally substituted C3-C8-cycloalkyl, optionally substituted C3-C8-cycloalkylalkyl, optionally substituted aryl, optionally substituted arylalkyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heterocyclyl, and optionally substituted heterocyclylalkyl;
• or R3 and R4, together with the nitrogen atom to which they are attached, together form an optionally substituted ring.