# US 2016/0355688 A1 · Coating For A Surface

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- Number: US 2016/0355688 A1
- Document ID: US20160355688A1
- Status: Published application
- Kind: A1
- Application number: 15/244,030
- Filed: 2016-08-23
- Published: 2016-12-08
- Earliest claimed: 2013-03-14
- Assignees: W. L. Gore & Associates, Inc.
- Applicants: W. L. Gore & Associates, Inc.
- Inventors: Paul D. Drumheller; Charles D. Claude
- Web page: https://patentgrep.com/patent/US20160355688A1

## CPC

- C09D 5/002: {Priming paints (C09D5/08 takes precedence)}
- A61L 27/34: Macromolecular materials
- A61L 29/085: {Macromolecular materials}
- A61L 31/10: Macromolecular materials
- A61L 31/16: Biologically active materials, e.g. therapeutic substances {(A61L31/047 takes precedence)}
- B05D 3/065: {After-treatment}
- C09D 7/63: organic
- C09D 131/04: Homopolymers or copolymers of vinyl acetate
- C09D 179/02: Polyamines
- A61L 2420/02: Methods for coating medical devices
- A61L 2420/06: Coatings containing a mixture of two or more compounds
- B05D 1/02: performed by spraying
- B05D 1/18: performed by dipping
- B05D 3/067: {Curing or cross-linking the coating}
- B05D 5/086: {having an anchoring layer}
- B05D 7/58: {No clear coat specified}
- Y10T 428/31544: Addition polymer is perhalogenated
- Y10T 428/31725: Of polyamide
- C09D: COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR (cosmetics A61K; processes for applying liquids or other fluent materials to surfaces, in general, B05D; staining wood B27K5/02; glazes or vitreous enamels C03C; natural resins, French polish, drying-oils, driers, turpentine, per se, C09F; polishing compositions other than French polish, ski waxes C09G; adhesives or use of materials as adhesives C09J; materials for sealing or packing joints or covers C09K3/10; materials for stopping leaks C09K3/12; processes for the electrolytic or electrophoretic production of coatings C25D)
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)
- B05D: PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL (conveying articles or workpieces through baths of liquid B65G, e.g. B65G49/02)
- Y10T: TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION

## Abstract

Coatings for a surface, especially a priming coating, of the present invention have been found to be durable, resistant to oxidative degradation, erosion and depolymerisation, stable to sterilization and low particulating, and are easily applied to the required surface of a substrate in a surface-independent manner. Such coatings, when used as priming coatings to be coated with a subsequent coating, in at least some embodiments, form exterior coatings which are also highly durable and are stable to sterilisation and aging.

## Claims

### Claim 1

A surface having a coating comprising a mixture of components A and B, wherein
component A is a polymer formed by self-polymerisation of a molecule comprising catechol functionality and amine and/or amide and/or hydroxyl functionality; and
component B comprises a polymer comprising photosensitive or thermosensitive moieties at least some of which moieties form covalent bonds with component A and which polymer forms an interpenetrating network with component A.

### Claim 2 (depends on 1)

A surface having a coating according to claim 1, wherein component B is a mixture of a cross-linking molecule comprising two or more photosensitive or thermosensitive moieties, at least some of which moieties form covalent bonds with component A, and a polymer comprising photosensitive or thermosensitive moieties at least some of which moieties form covalent bonds with component A and which polymer forms an interpenetrating network with component A.

### Claim 3 (depends on 1)

A surface having a coating according to claim 1, wherein component A is a catecholamine capable of self-polymerisation.

### Claim 4 (depends on 3)

A surface having a coating according to claim 3, wherein component A is dopamine.

### Claim 5 (depends on 1)

A surface having a coating according to claim 1, wherein the coating is covalently bonded to the surface.

### Claim 6 (depends on 1)

A surface having a coating according to claim 1, wherein the one or more photosensitive or thermosensitive moieties component B are capable of hydrogen abstraction.

### Claim 7 (depends on 6)

A surface having a coating according to claim 6, wherein the surface comprises abstractable hydrogen atoms and the coating is covalently bonded to the surface via abstraction of hydrogen atoms from the surface by at least some of the photosensitive or thermosensitive moieties of component B.

### Claim 8 (depends on 1)

A surface having a coating according to claim 1, wherein component B comprises one or more photosensitive moieties.

### Claim 9 (depends on 8)

A surface having a coating according to claim 8, wherein the one or more photosensitive moieties are selected from the group consisting of aryl ketone, diaryl ketone, aryl azide, alkenyl and alkynyl.

### Claim 10 (depends on 8)

A surface having a coating according to claim 8, wherein the one or more photosensitive moiety is a Type I or Type II photoinitiator,

### Claim 11 (depends on 10)

A surface having a coating according to claim 10, wherein the one or more photosensitive moiety is a Type II photoinitiator.

### Claim 12 (depends on 11)

A surface having a coating according to claim 11, wherein one or more photosensitive moiety is a diaryl ketone.

### Claim 13 (depends on 11)

A surface having a coating according to claim 11, wherein the one or more photosensitive moiety is benzophenone.

### Claim 14 (depends on 1)

A surface having a coating according to claim 1, wherein component B comprises one or more thermosensitive moieties.

### Claim 15 (depends on 1)

A surface having a coating according to claim 1, wherein component B comprises one or more photosensitive or thermosensitive moieties capable of forming a carbene or nitrene.

### Claim 16 (depends on 1)

A surface having a coating according to claim 1, wherein the surface has a subsequent coating,

### Claim 17 (depends on 16)

A surface having a coating according to claim 16, wherein the subsequent a coating is selected from the group consisting of a synthetic or naturally occurring organic or inorganic polymer or material, such as polyolefins, polyesters, polyurethanes, polyamides, polyether block amides, polycarbonates, polyphenylene sulfides, polyphenylene oxides, polyethers, silicones, polycarbonates, polyhydroxyethylmethacrylate polyvinyl pyrrolidone, polyvinyl alcohol, rubber, silicone rubber, polyhydroxyacids, polyallylamine, polyallylalcohol, polyacrylamide, polyamelic acid, styrenic polymers, polytetrafluoroethylene and copolymers thereof, bioresorbables, such as poly(D,L-lactide), polyglycolids and copolymers thereof, non-woven, bioabsorbable web materials comprising a tri-block copolymer such as poly(glycolide-co-trimethylene carbonate) tri-block copolymer (PGA:TMC), nylon 12, nylon 11, nylon 9, nylon 6/9 and nylon 6/6, polyetheresteramide, polyethylene terephthalate and polybutylene terephthalate, polyester ethers, polyester elastomer copolymers, block copolymer elastomers such as those copolymers having styrene end blocks, and midblocks formed from butadiene, isoprene, ethylene/butylene, ethylene/propene, styrenic block copolymers including acrylonitrile-styrene and acrylonitrile-butadiene-styrene block copolymers, polystyrenes, poly(methyl)methacrylates, polyacrylonitriles, poly(vinylacetates), poly(vinyl alcohols), chlorine-containing polymers such as poly(vinyl) chloride, polyoxymethylenes, polycarbonates, polyamides, polyimides, polyurethanes, phenolics, amino-epoxy resins, polyesters, silicones, cellulose-based plastics, rubber-like plastics, fluorinated polymers such as fluoropolymers, e.g. expanded polytetrafluoroethylene (ePTFE), polytetrafluoroethylene (PTFE), fluorinated ethylene-propylene (FEP), perfluorocarbon copolymers, e.g. tetrafluoroethylene perfluoroalkylvinyl ether (TFE/PAVE) copolymers, copolymers of tetrafluoroethylene (TFE) and perfluoromethyl vinyl ether (PMVE), copolymers of TFE with functional monomers that comprise acetate, alcohol, amine, amide, sulfonate, functional groups, expanded polyethylene, polyvinylchloride, polyurethane, silicone, polyethylene, polypropylene, polyurethane, polyglycolic acid, polyesters, polyamides, elastomers and their mixtures, blends and copolymers or derivatives.

### Claim 18 (depends on 16)

A surface having a coating according to claim 16, wherein the coating is covalently bonded to the subsequent coating.

### Claim 19 (depends on 16)

A surface having a coating according to claim 16, wherein the subsequent coating comprises a therapeutic agent.

### Claim 20 (depends on 19)

A surface having a coating according to claim 19, wherein the therapeutic agent is selected from the group consisting of an anti-thrombogenic agent, a hemostatic agent, an anti-angiogenic agent, an angiogenic agents, an anti-microbial agent, an anti-proliferative agent, a proliferative agent and an anti-inflammatory agent, or a combination thereof.

### Claim 21 (depends on 21)

A surface having a coating according to claim 21, wherein the surface is the surface of a substrate comprising a medical device.

### Claim 22 (depends on 21)

A surface having a coating according to claim 21, wherein the medical device is selected from the group consisting of stents including bifurcated stents, balloon expandable stents and self-expanding stents, stent-grafts including bifurcated stent-drafts, grafts including vascular grafts and bifurcated grafts, dialators, vascular occluders, embolic filters, embolectomy devices, catheters including microcatheters, central venous catheters, peripheral intravenous catheters and hemodialysis catheters, artificial blood vessels, sheaths including retractable sheaths, blood indwelling monitoring devices, artificial heart valves, pacemaker electrodes, guidewires, cardiac leads, cardiopulmonary bypass circuits, cannulae, plugs, drug delivery devices, balloons, tissue patch devices and blood pumps.