# US 2016/0355482 A1 · 6-heteroaryloxy- or 6-aryloxy-quinoline-2-carboxamides and method of use

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 2016/0355482 A1
- Document ID: US20160355482A1
- Status: Published application
- Kind: A1
- Application number: 15/239,554
- Filed: 2016-08-17
- Published: 2016-12-08
- Earliest claimed: 2014-02-06
- Assignees: AbbVie Inc.
- Applicants: AbbVie Inc.
- Inventors: Andrew Bogdan; Marlon D. Cowart; David A. DeGoey; Tammie K. Jinkerson; John R. Koenig; Michael E. Kort; Bo Liu; Mark A. Matulenko; Derek W. Nelson; Meena V. Patel; Hillary Peltier; Marc J. Scanio; Brian D. Wakefield
- Web page: https://patentgrep.com/patent/US20160355482A1

## CPC

- C07D 215/48: Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- A61P 1/02: Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A61P 25/00: Drugs for disorders of the nervous system
- A61P 25/02: for peripheral neuropathies
- A61P 25/04: Centrally acting analgesics, e.g. opioids
- A61P 25/06: Antimigraine agents
- A61P 29/00: Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P 29/02: without antiinflammatory effect
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C07D 401/12: linked by a chain containing hetero atoms as chain links
- C07D 401/14: containing three or more hetero rings
- C07D 405/12: linked by a chain containing hetero atoms as chain links
- C07D 405/14: containing three or more hetero rings
- C07D 409/12: linked by a chain containing hetero atoms as chain links
- C07D 409/14: containing three or more hetero rings
- C07D 417/12: linked by a chain containing hetero atoms as chain links
- C07D 417/14: containing three or more hetero rings
- C07D 471/04: Ortho-condensed systems
- C07D 487/04: Ortho-condensed systems
- C07D 487/08: Bridged systems
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

Compounds of formula (I) and pharmaceutically acceptable salts, esters, amides, or radiolabelled forms thereof, wherein R1, R2, and R3 are as defined in the specification, are useful in treating conditions or disorders prevented by or ameliorated by voltage-gated sodium channels, e.g., Nav1.7 and/or Nav1.8. Methods for making the compounds are disclosed. Also disclosed are pharmaceutical compositions of compounds of formula (I), and methods for using such compounds and compositions.

## Claims

### Claim 1

A compound of formula (I):
or a pharmaceutically acceptable salt, ester, amide, or radiolabelled form thereof, wherein:
R1 is selected from the group consisting of phenyl and monocyclic 5- or 6-membered heteroaryl, wherein the phenyl or 5- or 6-membered heteroaryl is unsubstituted or substituted with 1, 2, 3, 4, or 5 substituents selected from the group consisting of C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, halogen, cyano, —NO2, —OR1a, —OC(O)R1a, —OC(O)N(Rb)(R3a), —SR1a, —S(O)R2a, —S(O)2R2a, —S(O)2N(Rb)(R3a), —C(O)R1a, —C(O)OR1a, —C(O)N(Rb)(R3a), —N(Rb)(R3a), —N(Ra)C(O)R1a, —N(Ra)C(O)O(R1a), —N(Ra)C(O)N(Rb)(R3a), —(CR4aR5a)m—NO2, —N(Rb)S(O)2(R2a), —(CR4aR5a)m—OR1a, —(CR4aR5a)m—OC(O)R1a, —(CR4aR5a)m—OC(O)N(Rb)(R3a), —(CR4aR5a)m—SR1a, —(CR4aR5a)m—S(O)R2a, —(CR4aR5a)m—S(O)2R2a, —(CR4aR5a)m—S(O)2N(Rb)(R3a), —(CR4aR5a)m—C(O)R1a, —(CR4aR5a)m—C(O)OR1a, —(CR4aR5a)m—C(O)N(Ra)(R3a), —(CR4aR5a)m—N(Rb)(R3a), —(CR4aR5a)m—N(Ra)C(O)R1a, —(CR4aR5a)m—N(Ra)C(O)O(R1a), —(CR4aR5a)m—N(Ra)C(O)N(Rb)(R3a), (CR4aR5a)m—N(Rb)S(O)2(R2a), cyano-C1-C6-alkyl, and halo-C1-C6-alkyl;
Ra and Rb, at each occurrence, are each independently hydrogen, C1-C6-alkyl, or halo-C1-C6-alkyl;
R1a and R3a, at each occurrence, are each independently hydrogen, C1-C6-alkyl, or halo-C1-C6-alkyl;
R2a, at each occurrence, is independently C1-C6-alkyl or halo-C1-C6-alkyl;
R4a and R5a, at each occurrence, are each independently hydrogen, halogen, C1-C6-alkyl, or halo-C1-C6-alkyl;
m, at each occurrence, is independently 1, 2, 3, 4, or 5;
R2 is selected from the group consisting of hydrogen, C1-C6-alkyl, C1-C6-alkoxy-C1-C6-alkyl, and -G2;
R3 is selected from the group consisting of hydrogen, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, —(CR4bR5b)n—NO2, —(CR4bR5b)n—OR1b, —CH[(CR4bR5b)n—OR1b]2, —(CR4bR5b)n—OC(O)R1b, —(CR4bR5b)n—OC(O)N(Rb)(R3b), —(CR4bR5b)n—SR1b, —(CR4bR5b)n—S(O)2R2b, —(CR4bR5b)n—S(O)2N(Rb)(R3b), —(CR4bR5b)n—C(O)R1b, —(CR4bR5b)n—C(O)OR1b, —(CR4bR5b)n—C(O)N(Rb)(R3b), —(CR4bR5b)n—C(O)N(Rb)(—(CR4bR5b)n—OR1b), —(CR4bR5b)n—C(O)N(Rb)(G4), —(CR4bR5b)n—C(O)N(Rb)(G3), —(CR4bR5b)n—C(O)G4, —(CR4bR5b)n—N(Rb)(R3b), —(CR4bR5b)n—N(Rb)(G3), —(CR4bR5b)n—N(Ra)C(O)R1b, —(CR4bR5b)n—N(Rb)S(O)2R2b, —S(O)2R2b, —(CR4bR5b)n—N(Ra)C(O)O(R1b), —(CR4bR5b)n—N(Ra)C(O)N(Rb)(R3b), -G2, —(CR4bR5b)n-G4, -G2-G6, -G1, —(CR4bR5b)n-G3, —CH[C(O)N(Rb)(R3b)][—(CR4bR5b)n-G3], cyano-C1-C6-alkyl, and halo-C1-C6-alkyl;
R1b and R3b, at each occurrence, are each independently hydrogen, C1-C6-alkyl, or halo-C1-C6-alkyl;
R2b, at each occurrence, is independently C1-C6-alkyl or halo-C1-C6-alkyl;
R4b and R5b, at each occurrence, are each independently hydrogen, halogen, C1-C6-alkyl, or halo-C1-C6-alkyl;
n, at each occurrence, is independently 1, 2, 3, 4, or 5;
G1 and G3 are each independently aryl or heteroaryl; wherein G1 and G3 are each independently unsubstituted or substituted with 1, 2, 3, 4, or 5 substituents selected from the group consisting of C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, cyano, halo-C1-C6-alkyl, halogen, nitro, —N(Rc)2, —N(Rc)C(O)Rc, —ORc, —C(O)Rc, —C(O)ORc, —C(O)N(Rc)2, —SO2Rd, and —SO2N(Rc)2;
G2, G4 and G6 are each independently 3-6-membered-cycloalkyl, 3-6-membered-cycloalkenyl, or 4-10-membered-heterocycle; wherein G2, G4 and G6 are each independently unsubstituted or substituted with 1, 2, 3, 4, or 5 substituents selected from the group consisting of C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, benzyl, cyano, halo-C1-C6-alkyl, hydroxy-C1-C6-alkyl, halogen, nitro, oxo, —N(Rc)2, —N(Rc)C(O)Rc, —ORc, —C(O)Rc, —C(O)ORc, —C(O)N(Rc)2, —SO2Rd, —SO2N(Rc)2, and phenyl, wherein phenyl and the phenyl ring of benzyl are optionally substituted with 1, 2, 3, or 4 C1-C6-alkyl, halogen, or C1-C6-alkoxy;
Rc at each occurrence, is independently hydrogen, C1-C6-alkyl, aryl, aryl-C1-C6-alkyl, cycloalkyl, cycloalkyl-C1-C6-alkyl, or halo-C1-C6-alkyl; wherein said aryl, the aryl of aryl-C1-C6-alkyl, the cycloalkyl, and the cycloalkyl of cycloalkyl-C1-C6-alkyl are independently unsubstituted or substituted with 1, 2 3, 4, or 5 substituents independently selected from the group consisting of C1-C6-alkyl, halo-C1-C6-alkyl, and halogen;
Rd is C1-C6-alkyl or halo-C1-C6-alkyl; or
R2, R3 and the nitrogen atom to which they are attached form a 4-8-membered-monocylic heterocycle, 6-11-membered-bicyclic heterocycle, 10-12-membered-tricyclic heterocycle, 7-11-membered-spirocyclic heterocycle or 8-11-membered-bicyclic heteroaryl comprised of a monocyclic heterocycle fused to a monocyclic heteroaryl, wherein said 4-8-membered monocyclic heterocycle, said 6-11-membered-bicyclic heterocycle, said, 10-12-membered-tricyclic heterocycle, said 7-11-membered-spirocyclic heterocycle and said 8-11-membered-bicyclic heteroaryl are unsubstituted or substituted with 1, 2, 3, 4, or 5 substituents selected from the group consisting of C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, halogen, cyano, —NO2, —OR1c, —O—(CR4cR5c)p—OR1c, —OG13, —OC(O)R1c, —OC(O)N(Rb)(R3c), —SR1c, —S(O)R2c, —S(O)2R2c, —S(O)2G13, —S(O)2G14, —S(O)2N(Rb)(R3c), —S(O)2—(CR4cR5c)p—C(O)OR1c, —S(O)2—(CR4cR5c)p-G14, —C(O)R1c, —C(O)G14, —C(O)OR1c, —C(O)N(Rb)(R3c), —N(Rb)(R3c), —N(Ra)C(O)R1c, —N(Ra)C(O)G14, —N(Ra)C(O)O(Rc), —N(Ra)C(O)N(Rb)(R3c), —(CR4cR5c)p—NO2, —N(Rb)S(O)2(R2c), —N(Rb)S(O)2(G13), —(CR4cR5c)p—OR1c, —(CR4cR5c)p—O—(CR4cR5c)p—OR1c, —(CR4cR5c)p—OC(O)R1c, —(CR4cR5c)p—OC(O)N(Rb)(R3c), —(CR4cR5c)p—SR1c, —(CR4cR5c)p—S(O)R2c, —(CR4cR5c)p—S(O)2R2c, —(CR4cR5c)p—S(O)2N(Rb)(R3c), —(CR4cR5c)p—C(O)R1c, —(CR4cR5c)p—C(O)OR1c, —(CR4cR5c)p—C(O)N(Ra)(R3c), —(CR4cR5c)p—N(Rb)(R3c), —(CR4cR5c)p—N(Ra)C(O)R1c, —(CR4cR5c)p—N(Ra)C(O)O(R1c), —(CR4cR5c)p—N(Ra)C(O)O(CH2G13), —(CR4cR5c)p—N(Ra)C(O)N(Rb)(R3c), —(CR4cR5c)p—N(Rb)S(O)2(R2c), -G11, —(CR4cR5c)p-G13, —(CR4cR5c)p—OG13, -G12, —(CR4cR5c)p-G14, cyano-C1-C6-alkyl, oxo, C1-C6-alkoxyimino and halo-C1-C6-alkyl;
R1c and R3c, at each occurrence, are each independently hydrogen, C1-C6-alkyl, or halo-C1-C6-alkyl;
R2c, at each occurrence, is independently C1-C6-alkyl or halo-C1-C6-alkyl;
R4c and R5c, at each occurrence, are each independently hydrogen, halogen, C1-C6-alkyl, or halo-C1-C6-alkyl;
p, at each occurrence, is independently 1, 2, 3, 4, or 5;
G11 and G13 are each independently phenyl or 5-6-membered-heteroaryl; wherein G11 and G13 are each independently unsubstituted or substituted with 1, 2, 3, 4, or 5 substituents selected from the group consisting of C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, cyano, C1-C6-alkoxy-C1-C6-alkyl, halo-C1-C6-alkyl, halogen, nitro, —N(Re)2, —N(Re)C(O)Re, —ORe, —C(O)Re, —C(O)ORe, —C(O)N(Re)2, —SO2Rf, and —SO2N(Re)2;
G12, and G14 are each independently 3-6-membered-cycloalkyl, 3-6-membered-cycloalkenyl, or 4-10-membered-heterocycle, wherein G12 and G14 are each independently unsubstituted or substituted with 1, 2, 3, 4, or 5 substituents selected from the group consisting of C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, benzyl, cyano, halo-C1-C6-alkyl, hydroxy-C1-C6-alkyl, halogen, nitro, oxo, —N(Re)2, —N(Re)C(O)Re, —N(Re)S(O)2Rf, —ORe, —C(O)Re, —C(O)ORe, —C(O)N(Re)2, —SO2Rf, —SO2N(Re)2, and phenyl, wherein phenyl and the phenyl ring of benzyl are optionally substituted with C1-C6-alkyl, halogen, or C1-C6-alkoxy;
Re at each occurrence, is independently hydrogen, C1-C6-alkyl, aryl, aryl-C1-C6-alkyl, cycloalkyl, cycloalkyl-C1-C6-alkyl, or halo-C1-C6-alkyl; wherein said aryl, the aryl of aryl-C1-C6-alkyl, the cycloalkyl, and the cycloalkyl of cycloalkyl-C1-C6-alkyl are independently unsubstituted or substituted with 1, 2 3, 4, or 5 substituents independently selected from the group consisting of C1-C6-alkyl, halo-C1-C6-alkyl, and halogen; and
Rf is C1-C6-alkyl or halo-C1-C6-alkyl.

### Claim 2 (depends on 1)

The compound of claim 1, wherein,
R1 is phenyl, wherein the phenyl is unsubstituted or substituted with 1, 2, 3, or 4 substituents selected from the group consisting of C1-C6-alkyl, halogen, cyano, —OR1a, —S(O)2R2a, —S(O)2N(Rb)(R3a), —C(O)R1a, —(CR4aR5a)m—OR1a, and halo-C1-C6-alkyl;
Rb, at each occurrence, is independently hydrogen, C1-C6-alkyl, or halo-C1-C6-alkyl;
R1a and R3a, at each occurrence, are each independently hydrogen, C1-C6-alkyl, or halo-C1-C6-alkyl;
R2a, at each occurrence, is independently C1-C6-alkyl or halo-C1-C6-alkyl;
R4a and R5a, at each occurrence, are each independently hydrogen, C1-C6-alkyl, or halo-C1-C6-alkyl; and
m, at each occurrence, is independently 1, 2, or 3.

### Claim 3 (depends on 2)

The compound of claim 2, wherein,
R2 is selected from the group consisting of hydrogen, C1-C6-alkyl, C1-C6-alkoxy-C1-C6-alkyl, and -G2;
R3 is selected from the group consisting of hydrogen, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, —(CR4bR5b)n—OR1b, —CH[(CR4bR5b)n—OR1b]2, —(CR4bR5b)n—SR1b, —(CR4bR5b)n—S(O)2R2b, —(CR4bR5b)n—S(O)2N(Rb)(R3b), —(CR4bR5b)n—C(O)R1b, —(CR4bR5b)n—C(O)OR1b, —(CR4bR5b)n—C(O)N(Rb)(R3b), —(CR4bR5b)n—C(O)N(Rb)(—(CR4bR5b)n—OR1b), —(CR4bR5b)n—C(O)N(Rb)(G4), —(CR4bR5b)n—C(O)N(Rb)(G3), —(CR4bR5b)n—C(O)G4, —(CR4bR5b)n—N(Rb)(R3b), —(CR4bR5b)n—N(Rb)(G3), —(CR4bR5b)n—N(Ra)C(O)R1b, —(CR4bR5b)n—N(Rb)S(O)2R2b, —S(O)2R2b, —(CR4bR5b)n—N(Ra)C(O)O(R1b), —(CR4bR5b)n—N(Ra)C(O)N(Rb)(R3b), -G2, —(CR4bR5b)n-G4, -G2-G6, -G1, —(CR4bR5b)n-G3, —CH[C(O)N(Rb)(R3b)][—(CR4bR5b)n-G3], cyano-C1-C6-alkyl, and halo-C1-C6-alkyl;
Ra and Rb, at each occurrence, are each independently hydrogen, C1-C6-alkyl, or halo-C1-C6-alkyl;
Rb, at each occurrence, is independently hydrogen, C1-C6-alkyl, or halo-C1-C6-alkyl;
R1b and R3b, at each occurrence, are each independently hydrogen, C1-C6-alkyl, or halo-C1-C6-alkyl;
R2b, at each occurrence, is independently C1-C6-alkyl or halo-C1-C6-alkyl;
R4b and R5b, at each occurrence, are each independently hydrogen, C1-C6-alkyl, or halo-C1-C6-alkyl;
n, at each occurrence, is independently 1, 2, 3, 4, or 5;
G1 and G3 are each independently aryl or heteroaryl; wherein G1 and G3 are each independently unsubstituted or substituted with 1, 2, 3, 4, or 5 substituents selected from the group consisting of C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, cyano, halo-C1-C6-alkyl, halogen, nitro, —N(Rc)2, —N(Rc)C(O)Rc, —ORc, —C(O)Rc, —C(O)ORc, —C(O)N(Rc)2, —SO2Rd, and —SO2N(Rc)2;
G2, G4 and G6 are each independently 3-6-membered-cycloalkyl or 4-10-membered-heterocycle; wherein G2, G4 and G6 are each independently unsubstituted or substituted with 1, 2, 3, 4, or 5 substituents selected from the group consisting of C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, benzyl, cyano, halo-C1-C6-alkyl, hydroxy-C1-C6-alkyl, halogen, oxo, —N(Rc)2, —N(Rc)C(O)Rc, —ORc, —C(O)Rc, —C(O)ORc, —C(O)N(Rc)2, —SO2Rd, —SO2N(Rc)2, and phenyl, wherein phenyl and the phenyl ring of benzyl are optionally substituted with 1, 2, 3, or 4 C1-C6-alkyl, halogen, or C1-C6-alkoxy;
Rc at each occurrence, is independently hydrogen, C1-C6-alkyl, aryl, or halo-C1-C6-alkyl; wherein said aryl is independently unsubstituted or substituted with 1, 2 3, 4, or 5 substituents independently selected from the group consisting of C1-C6-alkyl, halo-C1-C6-alkyl, and halogen; and
Rd is C1-C6-alkyl or halo-C1-C6-alkyl.

### Claim 4 (depends on 3)

The compound of claim 3, wherein,
R2 is selected from the group consisting of hydrogen and C1-C6-alkyl;
R3 is selected from the group consisting of hydrogen, C1-C6-alkyl, C2-C6-alkenyl, —(CR4bR5b)n—OR1b, —CH[(CR4bR5b)n—OR1b]2, —(CR4bR5b)n—SR1b, —(CR4bR5b)n—S(O)2R2b, —(CR4bR5b)n—S(O)2N(Rb)(R3b), —(CR4bR5b)n—C(O)R1b, —(CR4bR5b)n—C(O)OR1b, —(CR4bR5b)n—C(O)N(Rb)(R3b), —(CR4bR5b)n—N(Rb)(R3b), —S(O)2R2b, and halo-C1-C6-alkyl;
Rb, at each occurrence, is independently hydrogen, C1-C6-alkyl, or halo-C1-C6-alkyl;
R1b and R3b, at each occurrence, are each independently hydrogen, C1-C6-alkyl, or halo-C1-C6-alkyl;
R2b, at each occurrence, is independently C1-C6-alkyl or halo-C1-C6-alkyl;
R4b and R5b, at each occurrence, are each independently hydrogen, C1-C6-alkyl, or halo-C1-C6-alkyl; and
n, at each occurrence, is independently 1, 2, 3, or 4.

### Claim 5 (depends on 3)

The compound of claim 3, wherein,
R2 is selected from the group consisting of hydrogen and C1-C6-alkyl;
R3 is selected from the group consisting of -G1 and —(CR4bR5b)n-G3;
R4b and R5b, at each occurrence, are each independently hydrogen, C1-C6-alkyl, or halo-C1-C6-alkyl;
n, at each occurrence, is independently 1, 2, 3, 4, or 5;
G1 and G3 are each independently aryl or heteroaryl; wherein G1 and G3 are each independently unsubstituted or substituted with 1, 2, 3, 4, or 5 substituents selected from the group consisting of C1-C6-alkyl, C2-C6-alkenyl, halo-C1-C6-alkyl, halogen, and —ORc; and
Rc at each occurrence, is independently C1-C6-alkyl, aryl, or
halo-C1-C6-alkyl; wherein said aryl is independently unsubstituted or substituted with 1, 2 3, 4, or 5 substituents independently selected from the group consisting of C1-C6-alkyl, halo-C1-C6-alkyl, and halogen.

### Claim 6 (depends on 3)

The compound of claim 3, wherein,
R2 is selected from the group consisting of hydrogen and C1-C6-alkyl;
R3 is selected from the group consisting of -G2 and —(CR4bR5b)n-G4;
R4b and R5b, at each occurrence, are each independently hydrogen, C1-C6-alkyl, or halo-C1-C6-alkyl;
n is 1, 2, 3, 4, or 5;
G2 and G4 are each independently 3-6-membered-cycloalkyl or 4-10-membered-heterocycle; wherein G2 and G4 are each independently unsubstituted or substituted with 1, 2, 3, 4, or 5 substituents selected from the group consisting of C1-C6-alkyl, C2-C6-alkenyl, benzyl, cyano, halo-C1-C6-alkyl, hydroxy-C1-C6-alkyl, halogen, oxo, —ORc, and phenyl, wherein phenyl and the phenyl ring of benzyl are optionally substituted with 1, 2, 3, or 4 C1-C6-alkyl, halogen, or C1-C6-alkoxy; and
Rc at each occurrence, is independently hydrogen, C1-C6-alkyl or halo-C1-C6-alkyl.

### Claim 7 (depends on 2)

The compound of claim 2, wherein
R2, R3 and the nitrogen atom to which they are attached form a 4-8-membered-monocylic heterocycle, 6-11-membered-bicyclic heterocycle, 10-12-membered-tricyclic heterocycle, 7-11-membered-spirocyclic heterocycle or 8-11-membered-bicyclic heteroaryl comprised of a 5-7-membered-monocyclic heterocycle fused to a 5-6-membered-monocyclic heteroaryl, wherein said 4-8-membered monocyclic heterocycle, said 6-11-membered-bicyclic heterocycle, said, 10-12-membered-tricyclic heterocycle, said 7-11-membered-spirocyclic heterocycle and said 8-11-membered-bicyclic heteroaryl are unsubstituted or substituted with 1, 2, 3, 4, or 5 substituents selected from the group consisting of C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, halogen, cyano, —OR1c, —O—(CR4cR5c)p—OR1c, —OG13, —SR1c, —S(O)R2c, —S(O)2R2c, —S(O)2G13, —S(O)2G14, —S(O)2N(Rb)(R3c), —S(O)2—(CR4cR5c)p—C(O)ORc, —S(O)2—(CR4cR5c)p-G14, —C(O)R1c, —C(O)G14, —C(O)OR1c, —C(O)N(Rb)(R3c), —N(Rb)(R3c), —N(Ra)C(O)R1c, —N(Ra)C(O)G14, —N(Ra)C(O)O(R1c), —N(Ra)C(O)N(Rb)(R3c), —N(Rb)S(O)2(R2c), —N(Rb)S(O)2(G13), —(CR4cR5c)p—OR1c, —(CR4cR5c)p—O—(CR4cR5c)p—OR1c, —(CR4cR5c)p—SR1c, —(CR4cR5c)p—S(O)R2c, —(CR4cR5c)p—S(O)2R2c, —(CR4cR5c)p—S(O)2N(Rb)(R3c), —(CR4cR5c)p—C(O)R1c, —(CR4cR5c)p—C(O)OR1c, —(CR4cR5c)p—C(O)N(Ra)(R3c), —(CR4cR5c)p—N(Rb)(R3c), —(CR4cR5c)p—N(Ra)C(O)R1c, —(CR4cR5c)p—N(Ra)C(O)O(R1c), —(CR4cR5c)p—N(Ra)C(O)O(CH2G13), —(CR4cR5c)p—N(Ra)C(O)N(Rb)(R3c), —(CR4cR5c)p—N(Rb)S(O)2(R2c), -G11, —(CR4cR5c)p-G13, —(CR4cR5c)p—OG13, -G12, —(CR4cR5c)p-G14, cyano-C1-C6-alkyl, oxo, C1-C6-alkoxyimino and halo-C1-C6-alkyl;
Ra and Rb, at each occurrence, are each independently hydrogen, C1-C6-alkyl, or halo-C1-C6-alkyl;
R1c and R3c, at each occurrence, are each independently hydrogen, C1-C6-alkyl, or halo-C1-C6-alkyl;
R2c, at each occurrence, is independently C1-C6-alkyl or halo-C1-C6-alkyl;
R4c and R5c, at each occurrence, are each independently hydrogen, C1-C6-alkyl, or halo-C1-C6-alkyl;
p, at each occurrence, is independently 1, 2, 3, 4, or 5;
G11 and G13 are each independently phenyl or 5-6-membered-heteroaryl; wherein G11 and G13 are each independently unsubstituted or substituted with 1, 2, 3, 4, or 5 substituents selected from the group consisting of C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, cyano, C1-C6-alkoxy-C1-C6-alkyl, halo-C1-C6-alkyl, halogen, —N(Re)C(O)Re, and —ORe;
G12, and G14 are each independently 3-6-membered-cycloalkyl, 3-6-membered-cycloalkenyl, or 4-10-membered-heterocycle, wherein G12 and G14 are each independently unsubstituted or substituted with 1, 2, 3, 4, or 5 substituents selected from the group consisting of C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, benzyl, cyano, halo-C1-C6-alkyl, hydroxy-C1-C6-alkyl, halogen, oxo, —N(Re)C(O)Re, —N(Re)S(O)2Rf, —ORe, —C(O)Re, —C(O)ORe, —C(O)N(Re)2, —SO2Rf, —SO2N(Re)2, and phenyl, wherein phenyl and the phenyl ring of benzyl are optionally substituted with C1-C6-alkyl, halogen, or C1-C6-alkoxy;
Re at each occurrence, is independently hydrogen, C1-C6-alkyl, aryl or halo-C1-C6-alkyl; wherein said aryl, is independently unsubstituted or substituted with 1, 2 3, 4, or 5 substituents independently selected from the group consisting of C1-C6-alkyl, halo-C1-C6-alkyl, and halogen; and
Rf is C1-C6-alkyl or halo-C1-C6-alkyl.

### Claim 8 (depends on 7)

The compound of claim 7, wherein
R2, R3 and the nitrogen atom to which they are attached form a 4-8-membered monocyclic heterocycle, wherein said 4-8-membered monocyclic heterocycle is unsubstituted or substituted with 1, 2, 3, 4, or 5 substituents selected from the group consisting of C1-C6-alkyl, halogen, cyano, —OR1c, —S(O)2R2c, —S(O)2N(Rb)(R3c), —C(O)R1c, —C(O)N(Rb)(R3c), —N(Rb)(R3c), —N(Ra)C(O)R1c, —(CR4cR5c)p—OR1c, —(CR4cR5c)p—S(O)2R2c, —(CR4cR5c)p—N(Rb)(R3c), -G12, —(CR4cR5c)p-G14, oxo, and halo-C1-C6-alkyl;
Ra and Rb, at each occurrence, are each independently hydrogen, C1-C6-alkyl, or halo-C1-C6-alkyl;
R1c and R3c, at each occurrence, are each independently hydrogen, C1-C6-alkyl, or halo-C1-C6-alkyl;
R2c, at each occurrence, is independently C1-C6-alkyl or halo-C1-C6-alkyl;
R4c and R5c, at each occurrence, are each independently hydrogen, C1-C6-alkyl, or halo-C1-C6-alkyl;
p, at each occurrence, is independently 1, 2, 3, 4, or 5; and
G12 and G14 are each independently 3-6-membered-cycloalkyl, 3-6-membered-cycloalkenyl, or 4-10-membered-heterocycle, wherein G12 and G14 are each independently unsubstituted or substituted with 1, 2, 3, 4, or 5 substituents selected from the group consisting of C1-C6-alkyl, cyano, halo-C1-C6-alkyl, halogen, and oxo.

### Claim 9 (depends on 8)

The compound of claim 8, wherein,
R1 is selected from the group consisting of 4-cyanophenyl and 4-acetylphenyl;
R2, R3 and the nitrogen atom to which they are attached form an azetidine, pyrrolidine or piperazine, wherein said azetidine, pyrrolidine or piperazine is unsubstituted or substituted with 1, 2, or 3 substituents selected from the group consisting of C1-C6-alkyl, halogen, —OR1c, —(CR4cR5c)p—OR1c, -G12, and halo-C1-C6-alkyl;
R1c, at each occurrence, is each independently hydrogen, C1-C6-alkyl, or halo-C1-C6-alkyl;
R4c and R5c, at each occurrence, are each independently hydrogen or C1-C6-alkyl;
p, at each occurrence, is independently 1, 2, or 3; and
G12, at each occurrence, is each independently 5-6-membered-heterocycle, wherein G12 is each independently unsubstituted or substituted with 1 or 2 substituents selected from the group consisting of C1-C6-alkyl, halogen, or oxo.

### Claim 10 (depends on 7)

The compound of claim 7, wherein
R2, R3 and the nitrogen atom to which they are attached form a 6-11-membered-bicyclic heterocycle, 10-12-membered-tricyclic heterocycle, or 7-11-membered-spirocyclic heterocycle, wherein said 6-11-membered-bicyclic heterocycle, said, 10-12-membered-tricyclic heterocycle, and said 7-11-membered-spirocyclic heterocycle are unsubstituted or substituted with 1, 2, 3, 4, or 5 substituents selected from the group consisting of C1-C6-alkyl, halogen, cyano, —OR1c, —S(O)2R2c, —S(O)2G13, —S(O)2G14, —S(O)2N(Rb)(R3c), —S(O)2—(CR4cR5c)p—C(O)OR1c, —S(O)2—(CR4cR5c)p-G14, —C(O)R1c, —C(O)G14, —C(O)OR1c, —C(O)N(Rb)(R3c), —N(Rb)(R3c), —N(Ra)C(O)R1c, —N(Ra)C(O)G14, —N(Rb)S(O)2(R2c), —N(Rb)S(O)2(G13), —(CR4cR5c)p—OR1c, —(CR4cR5c)p—O—(CR4cR5c)p—OR1c, —(CR4cR5c)p—S(O)2R2c, —(CR4cR5c)p—N(Rb)(R3c), —(CR4cR5c)p—N(Ra)C(O)O(CH2G13), -G11, —(CR4cR5c)p-G13, —(CR4cR5c)p—OG13, -G12, —(CR4cR5c)p-G14, cyano-C1-C6-alkyl, oxo, C1-C6-alkoxyimino and halo-C1-C6-alkyl;
Ra and Rb, at each occurrence, are each independently hydrogen, C1-C6-alkyl, or halo-C1-C6-alkyl;
R1c and R3c, at each occurrence, are each independently hydrogen, C1-C6-alkyl, or halo-C1-C6-alkyl;
R2c, at each occurrence, is independently C1-C6-alkyl or halo-C1-C6-alkyl;
R4c and R5c, at each occurrence, are each independently hydrogen, C1-C6-alkyl, or halo-C1-C6-alkyl;
p, at each occurrence, is independently 1, 2, 3, 4, or 5;
G11 and G13 are each independently phenyl or 5-6-membered-heteroaryl; wherein G11 and G13 are each independently unsubstituted or substituted with 1, 2, 3, 4, or 5 substituents selected from the group consisting of C1-C6-alkyl, C1-C6-alkoxy-C1-C6-alkyl, halo-C1-C6-alkyl, halogen, —N(Re)C(O)Re, and —ORe;
G12, and G14 are each independently 3-6-membered-cycloalkyl or 4-10-membered-heterocycle, wherein G12 and G14 are each independently unsubstituted or substituted with 1, 2, 3, 4, or 5 substituents selected from the group consisting of C1-C6-alkyl, halo-C1-C6-alkyl, hydroxy-C1-C6-alkyl, halogen, oxo, —N(Re)S(O)2Re, and —ORe; and
Re at each occurrence, is independently hydrogen, C1-C6-alkyl, aryl or halo-C1-C6-alkyl; wherein said aryl, is independently unsubstituted or substituted with 1, 2 3, 4, or 5 substituents independently selected from the group consisting of C1-C6-alkyl, halo-C1-C6-alkyl, and halogen.

### Claim 11 (depends on 7)

The compound of claim 7, wherein
R2, R3 and the nitrogen atom to which they are attached form a 8-11-membered-bicyclic heteroaryl comprised of a 5-7-membered-monocyclic heterocycle fused to a 5-6-membered-monocyclic heteroaryl, wherein said 8-11-membered-bicyclic heteroaryl is unsubstituted or substituted with 1, 2, 3, 4, or 5 substituents selected from the group consisting of C1-C6-alkyl, halogen, cyano, —OR1c, —S(O)2R2c, —S(O)2G13, —S(O)2G14, —S(O)2N(Rb)(R3c), —S(O)2—(CR4cR5c)p—C(O)OR1c, —S(O)2—(CR4cR5c)p-G14, —C(O)R1c, —C(O)G14, —C(O)OR1c, —C(O)N(Rb)(R3c), —N(Rb)(R3c), —N(Ra)C(O)R1c, —N(Ra)C(O)G14, —N(Rb)S(O)2(R2c), —N(Rb)S(O)2(G13), —(CR4cR5c)p—OR1c, —(CR4cR5c)p—O—(CR4cR5c)p—OR1c, —(CR4cR5c)p—S(O)2R2c, —(CR4cR5c)p—N(Rb)(R3c), —(CR4cR5c)p—N(Ra)C(O)O(CH2G13), -G11, —(CR4cR5c)p-G13, —(CR4cR5c)p—OG13, -G12, —(CR4cR5c)p-G14, cyano-C1-C6-alkyl, oxo, C1-C6-alkoxyimino and halo-C1-C6-alkyl;
Ra and Rb, at each occurrence, are each independently hydrogen, C1-C6-alkyl, or halo-C1-C6-alkyl;
R1c and R3c, at each occurrence, are each independently hydrogen, C1-C6-alkyl, or halo-C1-C6-alkyl;
R2c, at each occurrence, is independently C1-C6-alkyl or halo-C1-C6-alkyl;
R4c and R5c, at each occurrence, are each independently hydrogen, C1-C6-alkyl, or halo-C1-C6-alkyl;
p, at each occurrence, is independently 1, 2, 3, 4, or 5;
G11 and G13 are each independently phenyl or 5-6-membered-heteroaryl; wherein G11 and G13 are each independently unsubstituted or substituted with 1, 2, 3, 4, or 5 substituents selected from the group consisting of C1-C6-alkyl, C1-C6-alkoxy-C1-C6-alkyl, halo-C1-C6-alkyl, halogen, —N(Re)C(O)Re, and —ORe;
G12, and G14 are each independently 3-6-membered-cycloalkyl or 4-10-membered-heterocycle, wherein G12 and G14 are each independently unsubstituted or substituted with 1, 2, 3, 4, or 5 substituents selected from the group consisting of C1-C6-alkyl, halo-C1-C6-alkyl, hydroxy-C1-C6-alkyl, halogen, oxo, —N(Re)S(O)2Rf, and —ORe;
Re at each occurrence, is independently hydrogen, C1-C6-alkyl, aryl or halo-C1-C6-alkyl; wherein said aryl, is independently unsubstituted or substituted with 1, 2 3, 4, or 5 substituents independently selected from the group consisting of C1-C6-alkyl, halo-C1-C6-alkyl, and halogen; and
Rf is C1-C6-alkyl or halo-C1-C6-alkyl.

### Claim 12 (depends on 1)

The compound of claim 1, wherein,
R1 is 5- or 6-membered heteroaryl, wherein the 5- or 6-membered heteroaryl is unsubstituted or substituted with 1, 2, 3, or 4 substituents selected from the group consisting of C1-C6-alkyl, halogen, cyano, —OR1a, —S(O)2R2a, —S(O)2N(Rb)(R3a), —C(O)R1a, —(CR4aR5a)m—OR1a, and halo-C1-C6-alkyl;
Rb, at each occurrence, is independently hydrogen, C1-C6-alkyl, or halo-C1-C6-alkyl;
R1a and R3a, at each occurrence, are each independently hydrogen, C1-C6-alkyl, or halo-C1-C6-alkyl;
R2a, at each occurrence, is independently C1-C6-alkyl or halo-C1-C6-alkyl;
R4a and R5a, at each occurrence, are each independently hydrogen, C1-C6-alkyl, or halo-C1-C6-alkyl; and
m, at each occurrence, is independently 1, 2, or 3.

### Claim 13 (depends on 12)

The compound of claim 12, wherein,
R2 is selected from the group consisting of hydrogen, C1-C6-alkyl, C1-C6-alkoxy-C1-C6-alkyl, and -G2;
R3 is selected from the group consisting of hydrogen, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, —(CR4bR5b)n—OR1b, —CH[(CR4bR5b)n—OR1b]2, —(CR4bR5b)n—SR1b, —(CR4bR5b)n—S(O)2R2b, —(CR4bR5b)n—S(O)2N(Rb)(R3b), —(CR4bR5b)n—C(O)R1b, —(CR4bR5b)n—C(O)OR1b, —(CR4bR5b)n—C(O)N(Rb)(R3b), —(CR4bR5b)n—C(O)N(Rb)(—(CR4bR5b)n—OR1b), —(CR4bR5b)n—C(O)N(Rb)(G4), —(CR4bR5b)n—C(O)N(Rb)(G3), —(CR4bR5b)n—C(O)G4, —(CR4bR5b)n—N(Rb)(R3b), —(CR4bR5b)n—N(Rb)(G3), —(CR4bR5b)n—N(Ra)C(O)R1b, —(CR4bR5b)n—N(Rb)S(O)2R2b, —S(O)2R2b, —(CR4bR5b)n—N(Ra)C(O)O(R1b), —(CR4bR5b)n—N(Ra)C(O)N(Rb)(R3b), -G2, —(CR4bR5b)n-G4, -G2-G6, -G1, —(CR4bR5b)n-G3, —CH[C(O)N(Rb)(R3b)][—(CR4bR5b)n-G3], cyano-C1-C6-alkyl, and halo-C1-C6-alkyl;
Ra and Rb, at each occurrence, are each independently hydrogen, C1-C6-alkyl, or halo-C1-C6-alkyl;
R1b and R3b, at each occurrence, are each independently hydrogen, C1-C6-alkyl, or halo-C1-C6-alkyl;
R2b, at each occurrence, is independently C1-C6-alkyl or halo-C1-C6-alkyl;
R4b and R5b, at each occurrence, are each independently hydrogen, C1-C6-alkyl, or halo-C1-C6-alkyl;
n, at each occurrence, is independently 1, 2, 3, 4, or 5;
G1 and G3 are each independently aryl or heteroaryl; wherein G1 and G3 are each independently unsubstituted or substituted with 1, 2, 3, 4, or 5 substituents selected from the group consisting of C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, cyano, halo-C1-C6-alkyl, halogen, nitro, —N(Rc)2, —N(Rc)C(O)Rc, —ORc, —C(O)Rc, —C(O)ORc, —C(O)N(Rc)2, —SO2Rd, and —SO2N(Rc)2;
G2, G4 and G6 are each independently 3-6-membered-cycloalkyl or 4-10-membered-heterocycle; wherein G2, G4 and G6 are each independently unsubstituted or substituted with 1, 2, 3, 4, or 5 substituents selected from the group consisting of C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, benzyl, cyano, halo-C1-C6-alkyl, hydroxy-C1-C6-alkyl, halogen, oxo, —N(Rc)2, —N(Rc)C(O)Rc, —ORc, —C(O)Rc, —C(O)ORc, —C(O)N(Rc)2, —SO2Rd, —SO2N(Rc)2, and phenyl, wherein phenyl and the phenyl ring of benzyl are optionally substituted with 1, 2, 3, or 4 C1-C6-alkyl, halogen, or C1-C6-alkoxy;
Rc at each occurrence, is independently hydrogen, C1-C6-alkyl, aryl, or halo-C1-C6-alkyl; wherein said aryl is independently unsubstituted or substituted with 1, 2 3, 4, or 5 substituents independently selected from the group consisting of C1-C6-alkyl, halo-C1-C6-alkyl, and halogen; and
Rd is C1-C6-alkyl or halo-C1-C6-alkyl.

### Claim 14 (depends on 13)

The compound of claim 13, wherein,
R2 is selected from the group consisting of hydrogen, C1-C6-alkyl, and C1-C6-alkoxy-C1-C6-alkyl;
R3 is selected from the group consisting of hydrogen, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, —(CR4bR5b)n—OR1b, —CH[(CR4bR5b)n—OR1b]2, —(CR4bR5b)n—SR1b, —(CR4bR5b)n—S(O)2R2b, —(CR4bR5b)n—S(O)2N(Rb)(R3b), —(CR4bR5b)n—C(O)R1b, —(CR4bR5b)n—C(O)OR1b, —(CR4bR5b)n—C(O)N(Rb)(R3b), —(CR4bR5b)n—C(O)N(Rb)(—(CR4bR5b)n—OR1b), —(CR4bR5b)n—N(Rb)(R3b), —(CR4bR5b)n—N(Ra)C(O)R1b, —(CR4bR5b)n—N(Rb)S(O)2R2b, —S(O)2R2b, —(CR4bR5b)n—N(Ra)C(O)O(R1b), —(CR4bR5b)n—N(Ra)C(O)N(Rb)(R3b), cyano-C1-C6-alkyl, and halo-C1-C6-alkyl;
Ra and Rb, at each occurrence, are each independently hydrogen, C1-C6-alkyl, or halo-C1-C6-alkyl;
R1b and R3b, at each occurrence, are each independently hydrogen, C1-C6-alkyl, or halo-C1-C6-alkyl;
R2b, at each occurrence, is independently C1-C6-alkyl or halo-C1-C6-alkyl;
R4b and R5b, at each occurrence, are each independently hydrogen, C1-C6-alkyl, or halo-C1-C6-alkyl; and
n, at each occurrence, is independently 1, 2, 3, 4, or 5.

### Claim 15 (depends on 14)

The compound of claim 14, wherein,
R1 is selected from the group consisting of 5-(trifluoromethyl)pyridin-2-yl, 5-(difluoromethyl)pyridin-2-yl, and 6-(trifluoromethyl)pyridin-3-yl;
R2 is hydrogen;
R3 is selected from the group consisting of —(CR4bR5b)n—OR1b, —(CR4bR5b)n—C(O)N(Rb)(R3b), and halo-C1-C6-alkyl;
Rb is hydrogen, C1-C6-alkyl, or halo-C1-C6-alkyl;
R1b and R3b, at each occurrence, are each independently hydrogen or C1-C6-alkyl;
R4b and R5b, at each occurrence, are each independently hydrogen or C1-C6-alkyl; and
n, at each occurrence, is independently 1, 2, 3 or 4.

### Claim 16 (depends on 13)

The compound of claim 13, wherein,
R2 is selected from the group consisting of hydrogen and C1-C6-alkyl;
R3 is selected from the group consisting of —(CR4bR5b)n—C(O)N(Rb)(G3), —(CR4bR5b)n—N(Rb)(G3), -G1, —(CR4bR5b)n-G3, and —CH[C(O)N(Rb)(R3b)][—(CR4bR5b)n-G3];
Rb is hydrogen, C1-C6-alkyl, or halo-C1-C6-alkyl;
R3b is hydrogen, C1-C6-alkyl, or halo-C1-C6-alkyl;
R4b and R5b, at each occurrence, are each independently hydrogen, C1-C6-alkyl, or halo-C1-C6-alkyl;
n, at each occurrence, is independently 1, 2, 3, 4, or 5;
G1 and G3 are each independently aryl or heteroaryl; wherein G1 and G3 are each independently unsubstituted or substituted with 1, 2, 3, 4, or 5 substituents selected from the group consisting of C1-C6-alkyl and —OR; and
Rc at each occurrence, is independently hydrogen or C1-C6-alkyl.

### Claim 17 (depends on 13)

The compound of claim 13, wherein,
R2 is selected from the group consisting of hydrogen, C1-C6-alkyl, and -G2;
R3 is selected from the group consisting of —(CR4bR5b)n—C(O)N(Rb)(G4), —(CR4bR5b)n—C(O)G4, -G2, and —(CR4bR5b)n-G4, -G2-G6;
Rb is hydrogen, C1-C6-alkyl, or halo-C1-C6-alkyl;
R4b and R5b, at each occurrence, are each independently hydrogen, C1-C6-alkyl, or halo-C1-C6-alkyl;
n, at each occurrence, is independently 1, 2, 3, 4, or 5;
G2, G4 and G6 are each independently 3-6-membered-cycloalkyl or 4-10-membered-heterocycle; wherein G2, G4 and G6 are each independently unsubstituted or substituted with 1, 2, 3, 4, or 5 substituents selected from the group consisting of C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, benzyl, cyano, halo-C1-C6-alkyl, hydroxy-C1-C6-alkyl, halogen, oxo, —OR, and phenyl, wherein phenyl and the phenyl ring of benzyl are optionally substituted with 1, 2, 3, or 4 C1-C6-alkyl, halogen, or C1-C6-alkoxy; and
Rc at each occurrence, is independently hydrogen, C1-C6-alkyl, or halo-C1-C6-alkyl.

### Claim 18 (depends on 13)

The compound of claim 13, wherein,
R1 is selected from the group consisting of 5-(trifluoromethyl)pyridin-2-yl, 5-(difluoromethyl)pyridin-2-yl, and 6-(trifluoromethyl)pyridin-3-yl;
R2 is selected from the group consisting of hydrogen and C1-C6-alkyl;
R3 is -G2; and
G2 is a 4-6-membered-cycloalkyl or 4-6-membered-heterocycle; wherein G2 is unsubstituted or substituted with 1, 2, or 3 substituents selected from the group consisting of C1-C6-alkyl, halogen, and oxo.

### Claim 19 (depends on 12)

The compound of claim 12, wherein,
R2, R3 and the nitrogen atom to which they are attached form a 4-8-membered-monocylic heterocycle, 6-11-membered-bicyclic heterocycle, 10-12-membered-tricyclic heterocycle, 7-11-membered-spirocyclic heterocycle or 8-11-membered-bicyclic heteroaryl comprised of a 5-7-membered-monocyclic heterocycle fused to a 5-6-membered-monocyclic heteroaryl, wherein said 4-8-membered monocyclic heterocycle, said 6-11-membered-bicyclic heterocycle, said 10-12-membered-tricyclic heterocycle, said 7-11-membered-spirocyclic heterocycle and said 8-11-membered-bicyclic heteroaryl are unsubstituted or substituted with 1, 2, 3, 4, or 5 substituents selected from the group consisting of C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, halogen, cyano, —OR1c, —O—(CR4cR5C)p—OR1c, —OG13, —OC(O)R1c, —OC(O)N(Rb)(R3c), —SR1c, —S(O)R2c, —S(O)2R2c, —S(O)2G13, —S(O)2G14, —S(O)2N(Rb)(R3c), —S(O)2—(CR4cR5c)p—C(O)OR1c, —S(O)2—(CR4cR5c)p-G14, —C(O)R1c, —C(O)G14, —C(O)OR1c, —C(O)N(Rb)(R3c), —N(Rb)(R3c), —N(Ra)C(O)R1c, —N(Ra)C(O)G14, —N(Ra)C(O)O(R1c), —N(Ra)C(O)N(Rb)(R3c), —N(Rb)S(O)2(R2c), —N(Rb)S(O)2(G13), —(CR4cR5c)p—OR1c, —(CR4cR5c)p—O—(CR4cR5c)p—OR1c, —(CR4cR5c)p—OC(O)R1c, —(CR4cR5c)p—OC(O)N(Rb)(R3c), —(CR4cR5c)p—SR1c, —(CR4cR5c)p—S(O)R2c, —(CR4cR5c)p—S(O)2R2c, —(CR4cR5c)p—S(O)2N(Rb)(R3c), —(CR4cR5c)p—C(O)R1c, —(CR4cR5c)p—C(O)OR1c, —(CR4cR5c)p—C(O)N(Ra)(R3c), —(CR4cR5c)p—N(Rb)(R3c), —(CR4cR5c)p—N(Ra)C(O)R1c, —(CR4cR5c)p—N(Ra)C(O)O(R1c), —(CR4cR5c)p—N(Ra)C(O)O(CH2G13), —(CR4cR5c)p—N(Ra)C(O)N(Rb)(R3c), —(CR4cR5c)p—N(Rb)S(O)2(R2c), -G11, —(CR4cR5c)p-G13, —(CR4cR5c)p—OG13, -G12, —(CR4cR5c)p-G14, cyano-C1-C6-alkyl, oxo, C1-C6-alkoxyimino and halo-C1-C6-alkyl;
Ra and Rb, at each occurrence, are each independently hydrogen, C1-C6-alkyl, or halo-C1-C6-alkyl;
R1c and R3c, at each occurrence, are each independently hydrogen, C1-C6-alkyl, or halo-C1-C6-alkyl;
R2c, at each occurrence, is independently C1-C6-alkyl or halo-C1-C6-alkyl;
R4c and R5c, at each occurrence, are each independently hydrogen, C1-C6-alkyl, or halo-C1-C6-alkyl;
p, at each occurrence, is independently 1, 2, 3, 4, or 5;
G11 and G13 are each independently phenyl or 5-6-membered-heteroaryl; wherein G11 and G13 are each independently unsubstituted or substituted with 1, 2, 3, 4, or 5 substituents selected from the group consisting of C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, cyano, C1-C6-alkoxy-C1-C6-alkyl, halo-C1-C6-alkyl, halogen, —N(Re)C(O)Re, and —ORe;
G12, and G14 are each independently 3-6-membered-cycloalkyl, 3-6-membered-cycloalkenyl, or 4-10-membered-heterocycle, wherein G12 and G14 are each independently unsubstituted or substituted with 1, 2, 3, 4, or 5 substituents selected from the group consisting of C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, benzyl, cyano, halo-C1-C6-alkyl, hydroxy-C1-C6-alkyl, halogen, oxo, —N(Re)C(O)Re, —N(Re)S(O)2Rf, —ORe, —C(O)Re, —C(O)ORe, —C(O)N(Re)2, —SO2Rf, —SO2N(Re)2, and phenyl, wherein phenyl and the phenyl ring of benzyl are optionally substituted with C1-C6-alkyl, halogen, or C1-C6-alkoxy;
Re at each occurrence, is independently hydrogen, C1-C6-alkyl, aryl, or halo-C1-C6-alkyl; wherein said aryl is independently unsubstituted or substituted with 1, 2 3, 4, or 5 substituents independently selected from the group consisting of C1-C6-alkyl, halo-C1-C6-alkyl, and halogen; and
Rf is C1-C6-alkyl or halo-C1-C6-alkyl.

### Claim 20 (depends on 19)

The compound of claim 19, wherein,
R2, R3 and the nitrogen atom to which they are attached form a 4-8-membered-monocylic heterocycle, wherein said 4-8-membered monocyclic heterocycle is unsubstituted or substituted with 1, 2, 3, 4, or 5 substituents selected from the group consisting of C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, halogen, cyano, —OR1c, —O—(CR4cR5c)p—OR1c, —OG13, —SR1c, —S(O)R2c, —S(O)2R2c, —S(O)2G13, —S(O)2G14, —S(O)2N(Rb)(R3c), —S(O)2—(CR4cR5c)p—C(O)OR1c, —S(O)2—(CR4cR5c)p-G14, —C(O)R1c, —C(O)G14, —C(O)OR1c, —C(O)N(Rb)(R3c), —N(Rb)(R3c), —N(Ra)C(O)R1c, —N(Ra)C(O)G14, —N(Ra)C(O)O(R1c), —N(Ra)C(O)N(Rb)(R3c), —N(Rb)S(O)2(R2c), —N(Rb)S(O)2(G13), —(CR4cR5c)p—OR1c, —(CR4cR5c)p—O—(CR4cR5c)p—OR1c, —(CR4cR5c)p—S(O)R2c, —(CR4cR5c)p—S(O)2R2c, —(CR4cR5c)p—S(O)2N(Rb)(R3c), —(CR4cR5c)p—C(O)R1c, —(CR4cR5c)p—C(O)N(Ra)(R3c), —(CR4cR5c)p—N(Rb)(R3c), —(CR4cR5c)p—N(Ra)C(O)R1c, —(CR4cR5c)p—N(Ra)C(O)O(R1c), —(CR4cR5c)p—N(Ra)C(O)O(CH2G13), —(CR4cR5c)p—N(Ra)C(O)N(Rb)(R3c), —(CR4cR5c)p—N(Rb)S(O)2(R2c), -G11, —(CR4cR5c)p-G13, —(CR4cR5c)p—OG13, -G12, —(CR4cR5c)p-G14, cyano-C1-C6-alkyl, oxo, C1-C6-alkoxyimino and halo-C1-C6-alkyl;
Ra and Rb, at each occurrence, are each independently hydrogen, C1-C6-alkyl, or halo-C1-C6-alkyl;
R1c and R3c, at each occurrence, are each independently hydrogen, C1-C6-alkyl, or halo-C1-C6-alkyl;
R2c, at each occurrence, is independently C1-C6-alkyl or halo-C1-C6-alkyl;
R4c and R5c, at each occurrence, are each independently hydrogen, C1-C6-alkyl, or halo-C1-C6-alkyl;
p, at each occurrence, is independently 1, 2, 3, 4, or 5;
G11 and G13 are each independently phenyl or 5-6-membered-heteroaryl; wherein G11 and G13 are each independently unsubstituted or substituted with 1, 2, 3, 4, or 5 substituents selected from the group consisting of C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, cyano, C1-C6-alkoxy-C1-C6-alkyl, halo-C1-C6-alkyl, halogen, —N(Re)C(O)Re, and —ORe;
G12, and G14 are each independently 3-6-membered-cycloalkyl, 3-6-membered-cycloalkenyl, or 4-10-membered-heterocycle, wherein G12 and G14 are each independently unsubstituted or substituted with 1, 2, 3, 4, or 5 substituents selected from the group consisting of C1-C6-alkyl, C2-C6-alkenyl, cyano, halo-C1-C6-alkyl, hydroxy-C1-C6-alkyl, halogen, oxo, —N(Re)C(O)Re, —N(Re)S(O)2Rf, —ORe, —C(O)Re, —C(O)N(Re)2, —SO2Rf, —SO2N(Re)2;
Re at each occurrence, is independently hydrogen, C1-C6-alkyl, or halo-C1-C6-alkyl; and
Rf is C1-C6-alkyl or halo-C1-C6-alkyl.

### Claim 21 (depends on 20)

The compound of claim 20, wherein,
R1 is selected from the group consisting of 5-(trifluoromethyl)pyridin-2-yl, 5-(difluoromethyl)pyridin-2-yl, and 6-(trifluoromethyl)pyridin-3-yl;
R2, R3 and the nitrogen atom to which they are attached form an azetidine, pyrrolidine or piperazine, wherein said azetidine, pyrrolidine or piperazine is unsubstituted or substituted with 1, 2, or 3 substituents selected from the group consisting of C1-C6-alkyl, halogen, —OR1c, —(CR4cR5c)p—OR1c, -G12, and halo-C1-C6-alkyl;
R1c, at each occurrence, is each independently hydrogen, C1-C6-alkyl, or halo-C1-C6-alkyl;
R4c and R5c, at each occurrence, are each independently hydrogen or C1-C6-alkyl;
p, at each occurrence, is independently 1, 2, or 3; and
G12, at each occurrence, is each independently 5-6-membered-heterocycle, wherein G12 is each independently unsubstituted or substituted with 1 or 2 substituents selected from the group consisting of C1-C6-alkyl, halogen, or oxo.

### Claim 22 (depends on 19)

The compound of claim 19, wherein,
R2, R3 and the nitrogen atom to which they are attached form a 6-11-membered-bicyclic heterocycle, 10-12-membered-tricyclic heterocycle, or 7-11-membered-spirocyclic heterocycle, wherein said 6-11-membered-bicyclic heterocycle, said 10-12-membered-tricyclic heterocycle, or said 7-11-membered-spirocyclic heterocycle are unsubstituted or substituted with 1, 2, 3, or 4 substituents selected from the group consisting of C1-C6-alkyl, halogen, —OR1c, —N(Rb)(R3c), —(CR4cR5c)p—OR1c, oxo, and halo-C1-C6-alkyl;
Rb, at each occurrence, is independently hydrogen, C1-C6-alkyl, or halo-C1-C6-alkyl;
R1c and R3c, at each occurrence, are each independently hydrogen or C1-C6-alkyl;
R4c and R5c, at each occurrence, are each independently hydrogen or C1-C6-alkyl; and
p, at each occurrence, is independently 1, 2, 3, or 4.

### Claim 23 (depends on 19)

The compound of claim 19, wherein,
R2, R3 and the nitrogen atom to which they are attached form a 8-11-membered-bicyclic heteroaryl comprised of a 5-7-membered-monocyclic heterocycle fused to a 5-6-membered-monocyclic heteroaryl, wherein said 8-11-membered-bicyclic heteroaryl are unsubstituted or substituted with 1, 2, or 3 substituents selected from the group consisting of C1-C6-alkyl, halogen, cyano, —OR1c, —S(O)2R2c, —(CR4cR5c)p—OR1c, oxo, and halo-C1-C6-alkyl;
R1c, at each occurrence, is independently hydrogen, C1-C6-alkyl, or halo-C1-C6-alkyl;
R2c, at each occurrence, is independently C1-C6-alkyl or halo-C1-C6-alkyl;
R4c and R5c, at each occurrence, are each independently hydrogen and C1-C6-alkyl; and
p, at each occurrence, is independently 1, 2, 3, or 4.

### Claim 24 (depends on 1)

The compound of claim 1, selected from:
piperazin-1-yl(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
N-(1,1-dioxidotetrahydrothiophen-3-yl)-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
(1 S,4)-2,5-diazabicyclo[2.2.1]hept-2-yl(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
N-[(3S)-1,1-dioxidotetrahydrothiophen-3-yl]-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-[(3R)-1,1-dioxidotetrahydrothiophen-3-yl]-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
[3-(morpholin-4-yl)azetidin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
1-(4-{[2-(piperazin-1-ylcarbonyl)quinolin-6-yl]oxy}phenyl)ethanone;
(3-aminoazetidin-1-yl)(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
[cis-3,4-dihydroxypyrrolidin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
pyrrolidin-1-yl(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
[4-(morpholin-4-yl)piperidin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
[(3R)-3-methylpiperazin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
[(3S)-3-methylpiperazin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
(6-{[5-(difluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)(piperazin-1-yl)methanone;
N-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
[(3R)-3-ethylpiperazin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
[(3R)-3-(hydroxymethyl)piperazin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
(3-hydroxyazetidin-1-yl)(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
piperazin-1-yl(6-{[6-(trifluoromethyl)pyridin-3-yl]oxy}quinolin-2-yl)methanone;
[3-(trifluoromethyl)piperazin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
N-[2-(morpholin-4-yl)ethyl]-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-(2-methoxy ethyl)-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-(4,4-difluorocyclohexyl)-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-[(3S,4S)-4-hydroxy-1,1-dioxidotetrahydrothiophen-3-yl]-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
[2-(difluoromethyl)piperazin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
N-[(3R,4S)-4-hydroxy-1,1-dioxidotetrahydrothiophen-3-yl]-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
(8aS)-2-[(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)carbonyl]hexahydropyrrolo[1,2-a]pyrazin-4(1H)-one;
[4-(2-hydroxyethyl)piperazin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
[3-(methylsulfonyl)azetidin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
N-(2-hydroxy-2-methylpropyl)-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
[(3R)-3-(methoxymethyl)piperazin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
N-(1-oxidotetrahydro-2H-thiopyran-4-yl)-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-[2-(dimethylamino)-2-oxoethyl]-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-(cis-3-hydroxycyclobutyl)-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
(3-fluoropyrrolidin-1-yl)(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
meso-[(1R,5S,6s)-6-amino-3-azabicyclo[3.1.0]hex-3-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
N-(oxetan-2-ylmethyl)-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-[(2R)-2-hydroxypropyl]-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
4,7-diazaspiro[2.5]oct-7-yl(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
N-(2-oxopiperidin-4-yl)-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-(cis-3-methoxycyclobutyl)-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-[2-(dimethylamino)-2-oxoethyl]-6-{[6-(trifluoromethyl)pyridin-3-yl]oxy}quinoline-2-carboxamide;
(6-{[5-(difluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)[(3S)-3-methylpiperazin-1-yl]methanone;
N-[2-oxo-2-(pyrrolidin-1-yl)ethyl]-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-(1-ethyl-5-oxopyrrolidin-3-yl)-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
6-{[5-(difluoromethyl)pyridin-2-yl]oxy}-N-(1-ethyl-5-oxopyrrolidin-3-yl)quinoline-2-carboxamide;
(4-cyclobutylpiperazin-1-yl)(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
N-(3-methyloxetan-3-yl)-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
meso-[(1R,5S,6s)-6-amino-3-azabicyclo[3.1.0]hex-3-yl](6-{[5-(difluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
[(2S,4S)-4-fluoro-2-(hydroxymethyl)pyrrolidin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
[(3S)-3-fluoropyrrolidin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
[(3R)-3-fluoropyrrolidin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
[(8aS)-7,7-difluorohexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
N-[1-(4-fluorophenyl)-5-oxopyrrolidin-3-yl]-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
(6-{[5-(difluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)[(3R)-3-ethylpiperazin-1-yl]methanone;
N-(2-methoxyethyl)-6-{[6-(trifluoromethyl)pyridin-3-yl]oxy}quinoline-2-carboxamide;
(6-{[5-(difluoromethoxy)pyridin-2-yl]oxy}quinolin-2-yl)(piperazin-1-yl)methanone;
N-[(3R)-5-oxopyrrolidin-3-yl]-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-(3,3-difluorocyclobutyl)-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
[3-(methoxymethyl)azetidin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
N-ethyl-N-(1-ethyl-2-oxopiperidin-4-yl)-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
[(3R)-3-methylpiperazin-1-yl](6-{[6-(trifluoromethyl)pyridin-3-yl]oxy}quinolin-2-yl)methanone;
[(3R)-3-(methoxymethyl)piperazin-1-yl](6-{[6-(trifluoromethyl)pyridin-3-yl]oxy}quinolin-2-yl)methanone;
[(3S)-3-(methoxymethyl)piperazin-1-yl](6-{[6-(trifluoromethyl)pyridin-3-yl]oxy}quinolin-2-yl)methanone;
N-[3-(methylsulfonyl)propyl]-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
(3-aminoazetidin-1-yl)(6-{[6-(trifluoromethyl)pyridin-3-yl]oxy}quinolin-2-yl)methanone;
(6-{[5-(difluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)(3,5-dimethylpiperazin-1-yl)methanone;
(6-{[5-(difluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)[(3R)-3-methylpiperazin-1-yl]methanone;
(6-{[5-(difluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)[(3S)-3-(methoxymethyl)piperazin-1-yl]methanone;
{3-[(3R)-3-fluoropyrrolidin-1-yl]azetidin-1-yl}(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
(6-{[5-(difluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)[(3R)-3-(methoxymethyl)piperazin-1-yl]methanone;
[(2S*)-2-(difluoromethyl)piperazin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
N-[(3R*)-1-methyl-5-oxopyrrolidin-3-yl]-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-[(3S*)-1-methyl-5-oxopyrrolidin-3-yl]-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-(3,3,3-trifluoro-2-hydroxypropyl)-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
morpholin-4-yl[6-(pyridin-2-yloxy)quinolin-2-yl]methanone;
(4-methylpiperazin-1-yl)[6-(pyridin-2-yloxy)quinolin-2-yl]methanone;
[3-(3-methyl-1,2,4-oxadiazol-5-yl)piperidin-1-yl][6-(pyridin-2-yloxy)quinolin-2-yl]methanone;
N-[2-(piperidin-1-yl)ethyl]-6-(pyridin-2-yloxy)quinoline-2-carboxamide;
6-(pyridin-2-yloxy)-N-(1,2,4-thiadiazol-5-yl)quinoline-2-carboxamide;
4-({2-[(4-methylpiperazin-1-yl)carbonyl]quinolin-6-yl}oxy)benzonitrile;
6-(4-cyanophenoxy)-N-[2-(piperidin-1-yl)ethyl]quinoline-2-carboxamide;
4-{[2-(morpholin-4-ylcarbonyl)quinolin-6-yl]oxy}benzonitrile;
6-(4-cyanophenoxy)-N-(1H-indazol-6-yl)quinoline-2-carboxamide;
6-(4-cyanophenoxy)-N-[3-(dimethylamino)propyl]quinoline-2-carboxamide;
6-(4-cyanophenoxy)-N-[2-(morpholin-4-yl)ethyl]quinoline-2-carboxamide;
6-(4-cyanophenoxy)-N-[3-(morpholin-4-yl)propyl]quinoline-2-carboxamide;
6-(4-cyanophenoxy)-N-(1,3-thiazol-2-yl)quinoline-2-carboxamide;
6-(4-cyanophenoxy)-N-(pyridin-3-ylmethyl)quinoline-2-carboxamide;
6-(4-cyanophenoxy)-N-[(3S)-2-oxotetrahydrofuran-3-yl]quinoline-2-carboxamide;
6-(4-cyanophenoxy)-N-[(2R)-1-hydroxy-3-methylbutan-2-yl]quinoline-2-carboxamide;
6-(4-cyanophenoxy)-N-(2-thienylmethyl)quinoline-2-carboxamide;
6-(4-cyanophenoxy)-N-[2-(2-thienyl)ethyl]quinoline-2-carboxamide;
6-(4-cyanophenoxy)-N-(2-furylmethyl)quinoline-2-carboxamide;
6-(4-cyanophenoxy)-N-(1-hydroxy-3-methylbutan-2-yl)quinoline-2-carboxamide;
6-(4-cyanophenoxy)-N-[2-(pyrrolidin-1-yl)ethyl]quinoline-2-carboxamide;
6-(4-cyanophenoxy)-N-(pyridin-2-ylmethyl)quinoline-2-carboxamide;
6-(4-cyanophenoxy)-N-(pyridin-4-ylmethyl)quinoline-2-carboxamide;
6-(4-cyanophenoxy)-N-[(5-methyl-2-furyl)methyl]quinoline-2-carboxamide;
6-(4-cyanophenoxy)-N-[3-(piperidin-1-yl)propyl]quinoline-2-carboxamide;
6-(4-cyanophenoxy)-N-(4-phenoxyphenyl)quinoline-2-carboxamide;
6-(4-cyanophenoxy)-N-[3-(trifluoromethoxy)benzyl]quinoline-2-carboxamide;
6-(4-cyanophenoxy)-N-(4-methylbenzyl)quinoline-2-carboxamide;
N-(1,3-benzodioxol-5-ylmethyl)-6-(4-cyanophenoxy)quinoline-2-carboxamide;
6-(4-cyanophenoxy)-N-(2,3-dimethoxybenzyl)quinoline-2-carboxamide;
4-{[2-(azepan-1-ylcarbonyl)quinolin-6-yl]oxy}benzonitrile;
6-(4-cyanophenoxy)-N-(2-methoxy ethyl)-N-propylquinoline-2-carboxamide;
6-(4-cyanophenoxy)-N-(2-ethoxyethyl)quinoline-2-carboxamide;
N-(1-benzylpyrrolidin-3-yl)-6-(4-cyanophenoxy)quinoline-2-carboxamide;
4-[(2-{[3-(trifluoromethyl)piperidin-1-yl]carbonyl}quinolin-6-yl)oxy]benzonitrile;
4-{[2-(2, 3-dihydro-1H-indol-1-ylcarbonyl) quinolin-6-yl]oxy}benzonitrile;
4-{[2-(piperazin-1-ylcarbonyl)quinolin-6-yl]oxy}benzonitrile;
6-(4-cyanophenoxy)-N-[(3R)-2-oxotetrahydrofuran-3-yl]quinoline-2-carboxamide;
6-(4-cyanophenoxy)-N-(tetrahydrofuran-3-yl)quinoline-2-carboxamide;
6-(4-cyanophenoxy)-N-(methylsulfonyl)quinoline-2-carboxamide;
6-(4-cyanophenoxy)-N-(tetrahydro-2H-pyran-3-yl)quinoline-2-carboxamide;
6-(4-cyanophenoxy)-N-[(3R)-tetrahydrofuran-3-yl]quinoline-2-carboxamide;
6-(4-cyanophenoxy)-N-[(3S)-tetrahydrofuran-3-yl]quinoline-2-carboxamide;
6-(4-cyanophenoxy)-N-[(1R,2S)-2-hydroxycyclohexyl]quinoline-2-carboxamide;
6-(4-cyanophenoxy)-N-[(1S,2S)-2-hydroxycyclohexyl]quinoline-2-carboxamide;
6-(4-cyanophenoxy)-N-[(1S,2S)-2-hydroxycyclopentyl]quinoline-2-carboxamide;
6-(4-cyanophenoxy)-N-(2-hydroxy-2-methylpropyl)quinoline-2-carboxamide;
6-(4-cyanophenoxy)-N-[1-(hydroxymethyl)cyclopropyl]quinoline-2-carboxamide;
6-(4-cyanophenoxy)-N-(1-hydroxy-2-methylpropan-2-yl)quinoline-2-carboxamide;
6-(4-cyanophenoxy)-N-(trans-4-hydroxycyclohexyl)quinoline-2-carboxamide;
6-(4-cyanophenoxy)-N-(1,3-dihydroxypropan-2-yl)quinoline-2-carboxamide;
6-(4-cyanophenoxy)-N-(1-hydroxypropan-2-yl)quinoline-2-carboxamide;
6-(4-cyanophenoxy)-N-(2-hydroxypropy)quinoline-2-carboxamide;
6-(4-cyanophenoxy)-N-[(1S,3R)-3-hydroxycyclohexyl]quinoline-2-carboxamide;
6-(4-cyanophenoxy)-N-[(1S,3R)-3-hydroxycyclopentyl]quinoline-2-carboxamide;
6-(4-cyanophenoxy)-N-[(1R,2S)-2-hydroxycyclopentyl]quinoline-2-carboxamide;
6-(4-cyanophenoxy)-N-[(1S,3S)-3-hydroxycyclohexyl]quinoline-2-carboxamide;
6-(4-cyanophenoxy)-N-(cis-4-hydroxycyclohexyl)quinoline-2-carboxamide;
6-(4-cyanophenoxy)-N-(3-hydroxybutan-2-yl)quinoline-2-carboxamide,
6-(4-cyanophenoxy)-N-(2-hydroxy-3-methylbutyl)quinoline-2-carboxamide;
6-(4-cyanophenoxy)-N-(1,1-dioxidotetrahydrothiophen-3-yl)quinoline-2-carboxamide;
4-({2-[(3-oxopiperazin-1-yl)carbonyl]quinolin-6-yl}oxy)benzonitrile;
4-[(2-{[4-(morpholin-4-yl)piperidin-1-yl]carbonyl}quinolin-6-yl)oxy]benzonitrile;
6-(4-cyanophenoxy)-N-[(4R)-6-fluoro-3,4-dihydro-2H-chromen-4-yl]quinoline-2-carboxamide;
4-({2-[(4-tert-butylpiperazin-1-yl)carbonyl]quinolin-6-yl}oxy)benzonitrile;
6-(4-cyanophenoxy)-N-[(4R)-6-fluoro-2,2-dimethyl-3,4-dihydro-2H-chromen-4-yl]quinoline-2-carboxamide;
4-[(2-{[(3S)-3-isopropylpiperazin-1-yl]carbonyl}quinolin-6-yl)oxy]benzonitrile;
6-(4-cyanophenoxy)-N-(1-methyl-2-oxopyrrolidin-3-yl)quinoline-2-carboxamide;
6-(4-cyanophenoxy)-N-(1,3-oxazol-2-ylmethyl)quinoline-2-carboxamide;
6-(4-cyanophenoxy)-N-[2-(methylamino)-2-oxoethyl]quinoline-2-carboxamide;
N-(2-amino-2-oxoethyl)-6-(4-cyanophenoxy)quinoline-2-carboxamide;
6-(4-cyanophenoxy)-N-(2-sulfamoylethyl)quinoline-2-carboxamide;
4-({2-[(1,1-dioxidothiomorpholin-4-yl)carbonyl]quinolin-6-yl}oxy)benzonitrile;
N-(tetrahydrofuran-3-yl)-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-(2-amino-2-oxoethyl)-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-(pyridin-2-ylmethyl)-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
piperazin-1-yl(6-{[4-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
piperazin-1-yl(6-{[6-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
6-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}-N-(1,1-dioxidotetrahydrothiophen-3-yl)quinoline-2-carboxamide;
N-(1,1-dioxidotetrahydrothiophen-3-yl)-6-{[5-(trifluoromethyl)pyrimidin-2-yl]oxy}quinoline-2-carboxamide;
2-oxa-6-azaspiro[3.3]hept-6-yl(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
2,6-diazaspiro[3.3]hept-2-yl(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
6-[(5-cyanopyridin-2-yl)oxy]-N-(1,1-dioxidotetrahydrothiophen-3-yl)quinoline-2-carboxamide;
6-(4-cyanophenoxy)-N-[(3S)-1,1-dioxidotetrahydrothiophen-3-yl]quinoline-2-carboxamide;
6-(4-cyanophenoxy)-N-[(3R)-1,1-dioxidotetrahydrothiophen-3-yl]quinoline-2-carboxamide;
N-(1,1-dioxidotetrahydrothiophen-3-yl)-6-[(5-methylpyrimidin-2-yl)oxy]quinoline-2-carboxamide;
6-[(4,6-dimethylpyrimidin-2-yl)oxy]-N-(1,1-dioxidotetrahydrothiophen-3-yl)quinoline-2-carboxamide;
N-(1,1-dioxidotetrahydrothiophen-3-yl)-6-[(4-methylpyrimidin-2-yl)oxy]quinoline-2-carboxamide;
(3aR,6aS)-hexahydropyrrolo[3,4-c]pyrrol-2(1R)-yl(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
6-[(6-chloropyridazin-3-yl)oxy]-N-(1,1-dioxidotetrahydrothiophen-3-yl)quinoline-2-carboxamide;
(3aR,6aR)-5-[(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)carbonyl]hexahydropyrrolo[3,4-c]pyrrol-1(2H)-one;
(3aR,4R,7S,7aS)-octahydro-1H-4,7-epiminoisoindol-8-yl(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
N-(1,1-dioxidotetrahydrothiophen-3-yl)-6-{[6-(trifluoromethyl)pyridazin-3-yl]oxy}quinoline-2-carboxamide;
8-[(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)carbonyl]hexahydro-2H-pyrazino[1,2-a]pyrazin-1 (6H)-one;
5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
8-[(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)carbonyl]tetrahydro-2H-pyrazino[1,2-a]pyrazine-1,4(3H,6H)-dione;
4-[(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)carbonyl]piperazin-2-one;
5,6-dihydroimidazo[1,5-a]pyrazin-7(8H)-yl(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
N-[2-(pyrrolidin-1-yl)ethyl]-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-[2-(piperidin-1-yl)ethyl]-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
[4-(methylsulfonyl)piperazin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
[4-(isopropylsulfonyl)piperazin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
[4-(phenylsulfonyl)piperazin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
[(2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
[(2R,4R)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
[4-(2,2,2-trifluoroethyl)piperazin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
[4-(pyridin-2-yl)piperazin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
[4-(pyridin-3-ylsulfonyl)piperazin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
[4-(piperidin-1-ylsulfonyl)piperazin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
[4-(morpholin-4-ylsulfonyl)piperazin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
methyl 4-[(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)carbonyl]piperazine-1-carboxylate;
N,N-dimethyl-4-[(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)carbonyl]piperazine-1-carboxamide;
5-methyl-8-[(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)carbonyl]-2-oxa-5,8-diazaspiro[3.5]nonan-6-one;
2-[(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)carbonyl]hexahydroimidazo[1,5-a]pyrazin-3(2H)-one;
(3,3-difluoro-4-hydroxypiperidin-1-yl)(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
[cis-3-fluoro-4-hydroxypiperidin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
[cis-4-fluoro-3-hydroxypiperidin-l-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
(4,4-difluoro-3-hydroxypiperidin-1-yl)(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
[trans-3-ethyl-2-(hydroxymethyl)azetidin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
[trans-3-fluoro-4-hydroxypiperidin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
[trans-4-fluoro-3-hydroxypiperidin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)[(2R)-2,3,3-trimethylazetidin-1-yl]methanone;
(3-hydroxy-3-methylazetidin-1-yl)(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
[3-(methoxymethyl)-3-methylazetidin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
(3-methyl-3-phenoxyazetidin-1-yl)(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
(3-phenoxyazetidin-1-yl)(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
[3-(1H-imidazol-1-yl)azetidin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
[3-(4-chlorophenoxy)azetidin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
[3-(H-1,2,4-triazol-1-yl)azetidin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)[(2S)-2,3,3-trimethylazetidin-1-yl]methanone;
[3-(4-bromophenoxy)azetidin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
[3-(hydroxymethyl)-3-methylazetidin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
3-phenyl-4-[(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)carbonyl]piperazin-2-one;
{6-[4-(2-hydroxypropan-2-yl)phenoxy]quinolin-2-yl}(piperazin-1-yl)methanone;
6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
(4-methylpiperazin-1-yl)(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
(8S,9aS)-8-hydroxy-2-[(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)carbonyl]octahydro-5H-pyrrolo[1,2-a][1,4]diazepin-5-one;
(1S,6R)-3,8-diazabicyclo[4.2.0]oct-3-yl(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
{6-[4-(methylsulfonyl)phenoxy]quinolin-2-yl}(piperazin-1-yl)methanone;
piperazin-1-yl(6-{4-[(trifluoromethyl)sulfonyl]phenoxy}quinolin-2-yl)methanone;
N-(azetidin-3-yl)-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
[3-(pyridin-3-yl)azetidin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
1-{4-[(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)carbonyl]piperazin-1-yl}ethanone;
1,4-diazepan-1-yl(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
2,5-dihydro-1H-pyrrol-1-yl(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
thiomorpholin-4-yl(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
3,4-dihydro-2,7-naphthyridin-2(1H)-yl(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
[(2R,4S)-2-(2,5-difluorophenyl)-4-hydroxypyrrolidin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
{2-[4-(trifluoromethyl)phenyl]pyrrolidin-1-yl}(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
N-{(2R,3S)-2-phenyl-1-[(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)carbonyl]pyrrolidin-3-yl}-4-(trifluoromethyl)benzenesulfonamide;
1-(6-{[2-(piperazin-1-ylcarbonyl)quinolin-6-yl]oxy}pyridin-3-yl)ethanone;
(1,1-dioxidothiomorpholin-4-yl)(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
(4-tert-butylpiperazin-1-yl)(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
{6-[(5-fluoropyridin-2-yl)oxy]quinolin-2-yl}(piperazin-1-yl)methanone;
N-[(3aS,4R,6aR)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
(4-isopropylpiperazin-1-yl)(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
2,7-diazaspiro[3.5]non-2-yl(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
tetrahydropyrimidin-1(2H)-yl(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
[(2S)-2-(hydroxymethyl)piperazin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
N-methyl-4-[(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)carbonyl]piperazine-1-sulfonamide;
N-ethyl-4-[(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)carbonyl]piperazine-1-sulfonamide;
[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
azepan-1-yl(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
N-methyl-1-[(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)carbonyl]-L-prolinamide;
1,4-dioxa-8-azaspiro[4.5]dec-8-yl(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
(1R,4R)-2,5-diazabicyclo[2.2.1]hept-2-yl(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
piperazin-1-yl[6-(pyrimidin-2-yloxy)quinolin-2-yl]methanone;
[(2R)-2-(hydroxymethyl)piperazin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
{6-[(5-fluoropyrimidin-2-yl)oxy]quinolin-2-yl}(piperazin-1-yl)methanone;
piperazin-1-yl(6-{[5-(trifluoromethyl)pyrazin-2-yl]oxy}quinolin-2-yl)methanone;
piperazin-1-yl(6-{[6-(trifluoromethyl)pyridazin-3-yl]oxy}quinolin-2-yl)methanone;
piperazin-1-yl(6-{[5-(trifluoromethyl)pyrimidin-2-yl]oxy}quinolin-2-yl)methanone;
[(3aR,4S,6aS)-4-aminohexahydrocyclopenta[c]pyrrol-2(1H)-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
piperazin-1-yl {6-[4-(trifluoromethyl)phenoxy]quinolin-2-yl}methanone;
(6-{[3-fluoro-5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)(piperazin-1-yl)methanone;
N-[2-(methylsulfonyl)ethyl]-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
[4-(oxetan-3-yl)piperazin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
3,4-dihydroisoquinolin-2(1H)-yl(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
[4-(methylsulfonyl)piperidin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
(4-hydroxy-4-methylpiperidin-1-yl)(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
(4-hydroxypiperidin-1-yl)(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
[(1R,4R,6R)-6-(hydroxymethyl)-2-azabicyclo[2.2.1]hept-2-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
[(1R,4R,6S)-6-(hydroxymethyl)-2-azabicyclo[2.2.1]hept-2-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
N-[(3aR,4R,6aS)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
(4-methyl-1,4-diazepan-1-yl)(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
(4-cyclopropylpiperazin-1-yl)(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
(4-phenylpiperazin-1-yl)(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
[(3R)-3-isopropylpiperazin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
N-(piperidin-4-yl)-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
[4-(hydroxymethyl)piperidin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
[3-(hydroxymethyl)pyrrolidin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
N-(8-azabicyclo[3.2.1]oct-3-yl)-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
[4-(pyrazin-2-yl)piperazin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
[4-(pyridin-3-yl)piperazin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
[4-(pyrimidin-2-yl)piperazin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
[4-(pyridazin-3-yl)piperazin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
[4-(5-chloropyridin-2-yl)piperazin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
[(3S)-3-ethylpiperazin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
[(3S)-3-isopropylpiperazin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
{6-[4-(1-hydroxyethyl)phenoxy]quinolin-2-yl}(piperazin-1-yl)methanone;
[(3S)-3-(hydroxymethyl)piperazin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
isopropyl 4-[(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)carbonyl]piperazine-1-carboxylate;
(1S,5S)-3,6-diazabicyclo[3.2.0]hept-3-yl(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
1,6-diazaspiro[3.3]hept-1-yl(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
(3aS,6aS)-hexahydropyrrolo[3,4-b]pyrrol-5 (1H)-yl(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
N-(morpholin-4-yl)-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
[(3R)-3-hydroxypyrrolidin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
[(3S)-3-hydroxypyrrolidin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
(4-hydroxy azepan-1-yl)(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
N-(4-hydroxy-1,1-dioxidotetrahydrothiophen-3-yl)-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
{4-[(3-methyloxetan-3-yl)methyl]piperazin-1-yl}(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
[3-(methylsulfonyl)pyrrolidin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
2-[(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)carbonyl]hexahydropyrrolo[1,2-a]pyrazin-6(2H)-one;
ethyl 4-[(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)carbonyl]piperazine-1-carboxylate;
cyclopropyl{4-[(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)carbonyl]piperazin-1-yl}methanone;
(4-cyclohexylpiperazin-1-yl)(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
(3-fluoro-4-hydroxypyrrolidin-1-yl)(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
isobutyl 4-[(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)carbonyl]piperazine-1-carboxylate;
(4-ethylpiperazin-1-yl)(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
(6-{[3-bromo-5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)(piperazin-1-yl)methanone;
morpholin-4-yl(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
piperidin-1-yl(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
[4-(2,2-difluoroethyl)piperazin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
morpholin-4-yl {4-[(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)carbonyl]piperazin-1-yl}methanone;
[(2S,4R)-4-hydroxy-2-(hydroxymethyl)pyrrolidin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
[(3R)-3-fluoropyrrolidin-1-yl](6-{[5-(trifluoromethoxy)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
N-(trans-3-hydroxycyclobutyl)-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
[trans-3,4-dihydroxypyrrolidin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
[(2R,3S)-3-hydroxy-2-(hydroxymethyl)pyrrolidin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
[trans-3-hydroxy-4-methoxypyrrolidin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
[trans-3-hydroxy-4-methylpyrrolidin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
[cis-3,5-bis(hydroxymethyl)piperidin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
[4-(pyridin-2-ylmethyl)piperazin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
3,3-dimethyl-1-{4-[(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)carbonyl]piperazin-1-yl}butan-1-one;
[(3R)-3-aminopyrrolidin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)[4-(3,3,3-trifluoropropyl)piperazin-1-yl]methanone;
(3,3-difluoropiperidin-1-yl)(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
[(5S,7S)-7-hydroxy-1-azaspiro[4.4]non-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
[3-(azetidin-1-yl)pyrrolidin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
[4-(1,3-oxazol-4-ylmethyl)piperazin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
[3-(morpholin-4-yl)pyrrolidin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
N-(2-sulfamoylethyl)-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
(4-fluoropiperidin-1-yl)(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
[(3R)-3-(piperidin-1-yl)pyrrolidin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
piperazin-1-yl(6-{[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]oxy}quinolin-2-yl)methanone;
N-isopropyl-4-[(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)carbonyl]piperazine-2-carboxamide;
N-methyl-4-[(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)carbonyl]piperazine-2-carboxamide;
rac-[(3R,4S)-3,4-dihydroxy-2,5-dimethylpyrrolidin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
[cis-3,4-dimethoxypyrrolidin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
(3S)-1-[(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)carbonyl]piperidine-3-carboxamide;
N-(2-hydroxyethyl)-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-(tetrahydro-2H-pyran-4-yl)-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
6-{[2-(piperazin-1-ylcarbonyl)quinolin-6-yl]oxy}nicotinonitrile;
7-[(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)carbonyl]hexahydro[1,3]oxazolo[3,4-a]pyrazin-3-one;
(4,4-difluoropiperidin-1-yl)(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
N-[(3R)-pyrrolidin-3-yl]-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl) {4-[(3,3,3-trifluoropropyl)sulfonyl]piperazin-1-yl}methanone;
(8aR)-7-[(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)carbonyl]hexahydro[1,3]oxazolo[3,4-a]pyrazin-3-one;
N-(3-hydroxy-3-methylbutyl)-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-[(2R)-pyrrolidin-2-ylmethyl]-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-[(1-hydroxycyclobutyl)methyl]-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-[2-(2-oxopyrrolidin-1-yl)ethyl]-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-(2-aminoethyl)-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
[2-(hydroxymethyl)morpholin-4-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
[2-(fluoromethyl)morpholin-4-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
(1-hydroxy-7-azaspiro[3.5]non-7-yl)(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
6-[(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)carbonyl]-5, 6, 7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
4-[(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)carbonyl]-1,4-diazepan-2-one;
N-(2,2,2-trifluoroethyl)-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
(2-hydroxy-6-azaspiro[3.4]oct-6-yl)(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
N-(2-fluoroethyl)-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-(2,2-difluoroethyl)-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
[(3S,4S)-3-hydroxy-4-(methylsulfanyl)pyrrolidin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
N-(1,1-dioxidotetrahydro-2H-thiopyran-3-yl)-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
[cis-3,4-dihydroxypiperidin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
[trans-3-hydroxy-4-(methylsulfonyl)pyrrolidin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
1,4-dioxa-7-azaspiro[4.4]non-7-yl(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
[4-(methoxyimino)piperidin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
(2-hydroxy-7-azaspiro[3.5]non-7-yl)(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}-N-(3,3,3-trifluoropropyl)quinoline-2-carboxamide;
[(7S,8aR)-7-fluorohexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
[(3R,7S,8aR)-7-fluoro-3-methylhexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
[(3R,8aR)-7,7-difluoro-3-methylhexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
[(7S,8aS)-7-fluorohexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
N-[(4-benzylmorpholin-3-yl)methyl]-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-[(4-hydroxytetrahydro-2H-pyran-4-yl)methyl]-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-[(2S)-pyrrolidin-2-ylmethyl]-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-[2-(3,3-dimethylazetidin-1-yl)ethyl]-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-[2-(thiomorpholin-4-yl)ethyl]-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-allyl-N-methyl-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
1-[(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)carbonyl]azetidine-3-carbonitrile;
[cis-3-hydroxy-4-(methoxymethoxy)pyrrolidin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
N-[(1-hydroxycyclopropyl)methyl]-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
1-[(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)carbonyl]azetidin-3-one;
N-(4-hydroxytetrahydrofuran-3-yl)-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
5-{[2-(piperazin-1-ylcarbonyl)quinolin-6-yl]oxy}pyrazine-2-carbonitrile;
[cis-2,2-dimethyltetrahydro-5H-[1,3]dioxolo[4,5-c]pyrrol-5-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
{2-[(dimethylamino)methyl]morpholin-4-yl}(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
1-[(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)carbonyl]piperidin-4-one;
N,N-di(tetrahydro-2H-pyran-4-yl)-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
{4-[(1S,4S)-2-oxa-5-azabicyclo[2.2.1]hept-5-yl]piperidin-1-yl}(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
{4-[(1R,4R)-2-oxa-5-azabicyclo[2.2.1]hept-5-yl]piperidin-1-yl}(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
N,N-bis(2-methoxyethyl)-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-[1-(hydroxymethyl)cyclopropyl]-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
[4-(tetrahydrofuran-3-ylsulfonyl)piperazin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
methyl ({4-[(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)carbonyl]piperazin-1-yl}sulfonyl)acetate;
[4-(tetrahydro-2H-pyran-4-ylsulfonyl)piperazin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
(4-{[1-(2-methoxyethyl)-1H-pyrazol-4-yl]sulfonyl}piperazin-1-yl)(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
{4-[(tetrahydrofuran-3-ylmethyl)sulfonyl]piperazin-1-yl}(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
{4-[(1,1-dioxidotetrahydrothiophen-3-yl)sulfonyl]piperazin-1-yl}(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
{4-[(1-methyl-1H-pyrazol-4-yl)sulfonyl]piperazin-1-yl}(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
N-[4-methyl-5-({4-[(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)carbonyl]piperazin-1-yl}sulfonyl)-1,3-thiazol-2-yl]acetamide;
N-[5-({4-[(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)carbonyl]piperazin-1-yl}sulfonyl)-1,3-thiazol-2-yl]acetamide;
{4-[(1,5-dimethyl-1H-pyrazol-4-yl)sulfonyl]piperazin-1-yl}(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
N-[(3S)-tetrahydrofuran-3-yl]-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-(2-methoxy ethyl)-N-methyl-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-[(3R)-tetrahydrofuran-3-yl]-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-[(2S)-tetrahydrofuran-2-ylmethyl]-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
[(3R,5R)-3,5-dihydroxypiperidin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
(3-methoxyazetidin-1-yl)(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
N-(trans-3-methoxycyclobutyl)-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-(4-hydroxy-1,1-dioxidotetrahydrothiophen-3-yl)-N-methyl-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-(oxetan-3-yl)-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-(tetrahydro-2H-thiopyran-4-yl)-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-[(1S,2R)-2-hydroxycyclopentyl]-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
4-[(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)carbonyl]piperazine-2-carboxamide;
(4-aminopiperidin-1-yl)(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
(3,3-difluoropyrrolidin-1-yl)(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
(3,3-dimethylpyrrolidin-1-yl)(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
(6-fluoro-1,4-diazepan-1-yl)(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
(6-hydroxy-1,4-diazepan-1-yl)(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
N-{1-[(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)carbonyl]piperidin-4-yl}methanesulfonamide;
N-[(2R)-tetrahydrofuran-2-ylmethyl]-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-[(2S)-2-hydroxypropyl]-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-methyl-N-(tetrahydro-2H-pyran-4-yl)-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-[(3-hydroxyoxetan-3-yl)methyl]-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-[2-(dimethylamino)-2-oxoethyl]-N-methyl-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)[3-(trifluoromethyl)pyrrolidin-1-yl]methanone;
(3,4-difluoropyrrolidin-1-yl)(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
N-(6-oxopiperidin-3-yl)-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
(6,6-difluoro-1,4-diazepan-1-yl)(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
5,8-diazaspiro[3.5]non-8-yl(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
N-(1,1-dioxidotetrahydrothiophen-3-yl)-N-methyl-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-(tetrahydrothiophen-3-yl)-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-[2-(2-oxoimidazolidin-1-yl)ethyl]-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-[2-(pyridin-2-ylamino)ethyl]-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-[2-(1H-imidazol-1-yl)ethyl]-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-(azetidin-2-ylmethyl)-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-[(3R,4R)-4-hydroxy-1,1-dioxidotetrahydrothiophen-3-yl]-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-(3-hydroxy-3-methylcyclobutyl)-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
[3-(2-methoxy ethoxy)azetidin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
N-{1-[(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)carbonyl]azetidin-3-yl}methanesulfonamide;
(6-{[5-(difluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)[3-(morpholin-4-yl)azetidin-1-yl]methanone;
[2-(difluoromethyl)piperazin-1-yl](6-{[5-(difluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
piperazin-1-yl(6-{[5-(trifluoromethoxy)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
N-(3-oxocyclobutyl)-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-[3-(morpholin-4-yl)cyclobutyl]-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
6-{[5-(difluoromethyl)pyridin-2-yl]oxy}-N-(2-hydroxy-2-methylpropyl)quinoline-2-carboxamide;
(6-{[5-(difluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)[4-(morpholin-4-yl)piperidin-1-yl]methanone;
6-{[5-(difluoromethyl)pyridin-2-yl]oxy}-N-(2,2,2-trifluoroethyl)quinoline-2-carboxamide;
N-(4,4-difluorocyclohexyl)-6-{[5-(difluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-{(3R)-1-[(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)carbonyl]pyrrolidin-3-yl}acetamide;
N-{(3R)-1-[(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)carbonyl]pyrrolidin-3-yl}cyclopropanecarboxamide;
(6-{[5-(difluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)[(3R)-3-(hydroxymethyl)piperazin-1-yl]methanone;
6-{[5-(difluoromethyl)pyridin-2-yl]oxy}-N-[2-(dimethylamino)-2-oxoethyl]quinoline-2-carboxamide;
N-{2-[(2-methoxyethyl)amino]-2-oxoethyl}-N-methyl-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-[2-(morpholin-4-yl)-2-oxoethyl]-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-[3-(morpholin-4-yl)-3-oxopropyl]-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-[3-oxo-3-(pyrrolidin-1-yl)propyl]-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-[2-(diethylamino)-2-oxoethyl]-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-[2-oxo-2-(piperidin-1-yl)ethyl]-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-(1-methyl-5-oxopyrrolidin-3-yl)-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-[3-oxo-3-(piperidin-1-yl)propyl]-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
1-methyl-4-[(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)carbonyl]piperazin-2-one;
N,N-dimethyl-1-[(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)carbonyl]-L-prolinamide;
N-[2-(cyclopropylamino)-2-oxoethyl]-N-methyl-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-[3-(diethylamino)-3-oxopropyl]-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-[2-(isopropylamino)-2-oxoethyl]-N-methyl-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
1-[(6-{[5-(difluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)carbonyl]-N-methyl-L-prolinamide;
6-{[5-(difluoromethyl)pyridin-2-yl]oxy}-N-[2-oxo-2-(pyrrolidin-1-yl)ethyl]quinoline-2-carboxamide;
6-{[5-(difluoromethyl)pyridin-2-yl]oxy}-N-{2-[(2-methoxyethyl)amino]-2-oxoethyl}-N-methylquinoline-2-carboxamide;
6-{[5-(difluoromethyl)pyridin-2-yl]oxy}-N-[2-(morpholin-4-yl)-2-oxoethyl]quinoline-2-carboxamide;
6-{[5-(difluoromethyl)pyridin-2-yl]oxy}-N-[3-(morpholin-4-yl)-3-oxopropyl]quinoline-2-carboxamide;
6-{[5-(difluoromethyl)pyridin-2-yl]oxy}-N-[3-oxo-3-(pyrrolidin-1-yl)propyl]quinoline-2-carboxamide;
N-[2-(diethylamino)-2-oxoethyl]-6-{[5-(difluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
6-{[5-(difluoromethyl)pyridin-2-yl]oxy}-N-(1-methyl-5-oxopyrrolidin-3-yl)quinoline-2-carboxamide;
6-{[5-(difluoromethyl)pyridin-2-yl]oxy}-N-[3-oxo-3-(piperidin-1-yl)propyl]quinoline-2-carboxamide;
4-[(6-{[5-(difluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)carbonyl]-1-methylpiperazin-2-one;
1-[(6-{[5-(difluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)carbonyl]-N,N-dimethyl-L-prolinamide;
N-[2-(cyclopropylamino)-2-oxoethyl]-6-{[5-(difluoromethyl)pyridin-2-yl]oxy}-N-methylquinoline-2-carboxamide;
N-[3-(diethylamino)-3-oxopropyl]-6-{[5-(difluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
6-{[5-(difluoromethyl)pyridin-2-yl]oxy}-N-[2-(isopropylamino)-2-oxoethyl]-N-methylquinoline-2-carboxamide;
N-[2-(2-oxopiperazin-1-yl)ethyl]-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-(azetidin-3-ylmethyl)-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-(2-hydroxy-2-methylpropyl)-6-{[6-(trifluoromethyl)pyridin-3-yl]oxy}quinoline-2-carboxamide;
4-{4-[(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)carbonyl]piperazin-1-yl}butanenitrile;
3-{4-[(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)carbonyl]piperazin-1-yl}propanenitrile;
1-[(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)carbonyl]piperidine-4-carbonitrile;
6-{[5-(difluoromethyl)pyridin-2-yl]oxy}-N-(oxetan-3-yl)quinoline-2-carboxamide;
5,8-dioxa-2-azaspiro[3.4]oct-2-yl(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
6-{[5-(difluoromethyl)pyridin-2-yl]oxy}-N-[(3S,4S)-4-hydroxy-1,1-dioxidotetrahydrothiophen-3-yl]quinoline-2-carboxamide;
tetrahydro-5H-[1,3]dioxolo[4,5-c]pyrrol-5-yl(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
(6-{[5-(difluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)[3-(methylsulfonyl)azetidin-1-yl]methanone;
N-methyl-N-(oxetan-3-yl)-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
6-{[5-(difluoromethyl)pyridin-2-yl]oxy}-N-(1-oxidotetrahydro-2H-thiopyran-4-yl)quinoline-2-carboxamide;
N-(oxetan-3-ylmethyl)-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
4-[(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)carbonyl]piperazine-2-carbonitrile;
6-(4-cyanophenoxy)-N-(2-oxopiperidin-4-yl)quinoline-2-carboxamide;
N-(3,3-difluorocyclopentyl)-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-(3,3-difluorocyclopentyl)-6-{[5-(difluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
[3-fluoro-3-(methoxymethyl)pyrrolidin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
[13-(ethoxymethyl)-3-fluoropyrrolidin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
{3-fluoro-3-[(pyridin-4-yloxy)methyl]pyrrolidin-1-yl}(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
{3-fluoro-3-[(pyridin-3-yloxy)methyl]pyrrolidin-1-yl}(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
[3-fluoro-3-(phenoxy methyl)pyrrolidin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
benzyl ({4-fluoro-1-[(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)carbonyl]pyrrolidin-3-yl}methyl)carbamate;
{3-fluoro-3-[(2-methoxyethoxy)methyl]pyrrolidin-1-yl}(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
2-oxa-6-azaspiro[3.4]oct-6-yl(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
[(2R,4S)-4-fluoro-2-(hydroxy methyl)pyrrolidin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
[(2R)-4,4-difluoro-2-(hydroxymethyl)pyrrolidin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
[(2S)-4,4-difluoro-2-(hydroxymethyl)pyrrolidin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
1-(3-methoxyphenyl)-4-[(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)carbonyl]piperazin-2-one;
N-(thietan-3-yl)-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-{3-[(2-methylphenyl)amino]-3-oxopropyl}-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-[(2S)-1-(dimethylamino)-1-oxo-3-phenylpropan-2-yl]-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-[1-(2-methoxyphenyl)-5-oxopyrrolidin-3-yl]-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-(1-oxidothietan-3-yl)-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-(1,1-dioxidothietan-3-yl)-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
6-oxa-1-azaspiro[3.3]hept-1-yl(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
1-{1-[(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)carbonyl]azetidin-3-yl}ethanone;
(3-fluoroazetidin-1-yl)(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
(3,3-difluoroazetidin-1-yl)(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
(4R)-4-fluoro-N,N-dimethyl-1-[(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)carbonyl]-L-prolinamide;
[4-(1,3-oxazol-2-ylmethyl)piperazin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
N-(4,4-difluorocyclohexyl)-6-{[6-(trifluoromethyl)pyridin-3-yl]oxy}quinoline-2-carboxamide;
N-[(4S)-2-oxopiperidin-4-yl]-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-[2-oxo-2-(pyrrolidin-1-yl)ethyl]-6-{[6-(trifluoromethyl)pyridin-3-yl]oxy}quinoline-2-carboxamide;
N-{2-[(2-methoxyethyl)amino]-2-oxoethyl}-N-methyl-6-{[6-(trifluoromethyl)pyridin-3-yl]oxy}quinoline-2-carboxamide;
N-[3-(morpholin-4-yl)-3-oxopropyl]-6-{[6-(trifluoromethyl)pyridin-3-yl]oxy}quinoline-2-carboxamide;
N-[3-oxo-3-(pyrrolidin-1-yl)propyl]-6-{[6-(trifluoromethyl)pyridin-3-yl]oxy}quinoline-2-carboxamide;
N-[2-(diethylamino)-2-oxoethyl]-6-{[6-(trifluoromethyl)pyridin-3-yl]oxy}quinoline-2-carboxamide;
N-[2-oxo-2-(piperidin-1-yl)ethyl]-6-{[6-(trifluoromethyl)pyridin-3-yl]oxy}quinoline-2-carboxamide;
N-(1-methyl-5-oxopyrrolidin-3-yl)-6-{[6-(trifluoromethyl)pyridin-3-yl]oxy}quinoline-2-carboxamide;
N-[3-oxo-3-(piperidin-1-yl)propyl]-6-{[6-(trifluoromethyl)pyridin-3-yl]oxy}quinoline-2-carboxamide;
N-[(4R)-2-oxopiperidin-4-yl]-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-[2-(cyclopropylamino)-2-oxoethyl]-N-methyl-6-{[6-(trifluoromethyl)pyridin-3-yl]oxy}quinoline-2-carboxamide;
N-(1-ethyl-5-oxopyrrolidin-3-yl)-6-{[6-(trifluoromethyl)pyridin-3-yl]oxy}quinoline-2-carboxamide;
N-[3-(diethylamino)-3-oxopropyl]-6-{[6-(trifluoromethyl)pyridin-3-yl]oxy}quinoline-2-carboxamide;
N-[2-(isopropylamino)-2-oxoethyl]-N-methyl-6-{[6-(trifluoromethyl)pyridin-3-yl]oxy}quinoline-2-carboxamide;
[4-(morpholin-4-yl)piperidin-1-yl](6-{[6-(trifluoromethyl)pyridin-3-yl]oxy}quinolin-2-yl)methanone;
N-methyl-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
meso-[(1R,5S,6s)-6-amino-3-azabicyclo[3.1.0]hex-3-yl](6-{[6-(trifluoromethyl)pyridin-3-yl]oxy}quinolin-2-yl)methanone;
N-methyl-N-(1-methyl-2-oxopiperidin-4-yl)-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-[(3R)-2-oxotetrahydrofuran-3-yl]-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
{4-[(2-methyl-1,3-oxazol-4-yl)methyl]piperazin-1-yl}(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
6-oxa-2-azaspiro[3.4]oct-2-yl(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
6-oxa-2-azaspiro[3.5]non-2-yl(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
[3-(methylsulfonyl)azetidin-1-yl](6-{[6-(trifluoromethyl)pyridin-3-yl]oxy}quinolin-2-yl)methanone;
N-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-6-{[6-(trifluoromethyl)pyridin-3-yl]oxy}quinoline-2-carboxamide;
N-(oxetan-3-yl)-6-{[6-(trifluoromethyl)pyridin-3-yl]oxy}quinoline-2-carboxamide;
N-[(3R,4S)-4-hydroxy-1,1-dioxidotetrahydrothiophen-3-yl]-6-{[6-(trifluoromethyl)pyridin-3-yl]oxy}quinoline-2-carboxamide;
N-[(3S,4S)-4-hydroxy-1,1-dioxidotetrahydrothiophen-3-yl]-6-{[6-(trifluoromethyl)pyridin-3-yl]oxy}quinoline-2-carboxamide;
2,5-dihydro-1H-pyrrol-1-yl(6-{[6-(trifluoromethyl)pyridin-3-yl]oxy}quinolin-2-yl)methanone;
[4-(3,3-difluoroazetidin-1-yl)piperidin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
N-(2-methoxy-2-methylpropyl)-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
[(8aS)-7,7-difluorohexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl](6-{[5-(difluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
[(3R)-3-ethylpiperazin-1-yl](6-{[6-(trifluoromethyl)pyridin-3-yl]oxy}quinolin-2-yl)methanone;
[(3R)-3-(hydroxymethyl)piperazin-1-yl](6-{[6-(trifluoromethyl)pyridin-3-yl]oxy}quinolin-2-yl)methanone;
[(3S)-3-(hydroxymethyl)piperazin-1-yl](6-{[6-(trifluoromethyl)pyridin-3-yl]oxy}quinolin-2-yl)methanone;
[cis-3,4-dihydroxypyrrolidin-1-yl](6-{[6-(trifluoromethyl)pyridin-3-yl]oxy}quinolin-2-yl)methanone;
N-[2-(trifluoromethoxy)ethyl]-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
[(3R)-3-fluoropyrrolidin-1-yl](6-{[6-(trifluoromethyl)pyridin-3-yl]oxy}quinolin-2-yl)methanone;
[(3S)-3-methylpiperazin-1-yl](6-{[6-(trifluoromethyl)pyridin-3-yl]oxy}quinolin-2-yl)methanone;
[(3S)-3-fluoropyrrolidin-1-yl](6-{[6-(trifluoromethyl)pyridin-3-yl]oxy}quinolin-2-yl)methanone;
N-(3,3,3-trifluoro-2-hydroxypropyl)-6-{[6-(trifluoromethyl)pyridin-3-yl]oxy}quinoline-2-carboxamide;
(3,5-dimethylpiperazin-1-yl)(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
[(3S)-3-ethylpiperazin-1-yl](6-{[6-(trifluoromethyl)pyridin-3-yl]oxy}quinolin-2-yl)methanone;
[3-(morpholin-4-yl)azetidin-1-yl](6-{[6-(trifluoromethyl)pyridin-3-yl]oxy}quinolin-2-yl)methanone;
N-(3,3-difluorocyclobutyl)-6-{[6-(trifluoromethyl)pyridin-3-yl]oxy}quinoline-2-carboxamide;
N-(3-oxocyclobutyl)-6-{[6-(trifluoromethyl)pyridin-3-yl]oxy}quinoline-2-carboxamide;
[3-(piperazin-1-yl)azetidin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
4,7-diazaspiro[2.5]oct-7-yl(6-{[5-(difluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
N-{2-[(3R)-3-hydroxypyrrolidin-1-yl]-2-oxoethyl}-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-{2-[(3S)-3-hydroxypyrrolidin-1-yl]-2-oxoethyl}-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-[2-(3-hydroxy-3-methylpyrrolidin-1-yl)-2-oxoethyl]-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-{2-[(3S,4S)-3,4-dihydroxypyrrolidin-1-yl]-2-oxoethyl}-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-{2-[(3R,4R)-3,4-dihydroxypyrrolidin-1-yl]-2-oxoethyl}-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-{2-[(2S,4R)-4-hydroxy-2-(hydroxymethyl)pyrrolidin-1-yl]-2-oxoethyl}-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-[2-(3,3-difluoropyrrolidin-1-yl)-2-oxoethyl]-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-[2-(3-hydroxyazetidin-1-yl)-2-oxoethyl]-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-[2-(3-hydroxy-3-methylazetidin-1-yl)-2-oxoethyl]-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-[2-(1,1-dioxido-1,3-thiazolidin-3-yl)-2-oxoethyl]-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-[2-(3-methoxyazetidin-1-yl)-2-oxoethyl]-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-{2-[(2R)-2-(hydroxymethyl)pyrrolidin-1-yl]-2-oxoethyl}-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-[2-(azetidin-1-yl)-2-oxoethyl]-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-[2-oxo-2-(3-oxopyrrolidin-1-yl)ethyl]-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-[2-(3-fluoropyrrolidin-1-yl)-2-oxoethyl]-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-[3-(morpholin-4-yl)cyclobutyl]-6-{[6-(trifluoromethyl)pyridin-3-yl]oxy}quinoline-2-carboxamide;
(6-{[5-(difluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)[(3R)-3-fluoropyrrolidin-1-yl]methanone;
(6-{[5-(difluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)[(3S)-3-fluoropyrrolidin-1-yl]methanone;
N-(methylsulfonyl)-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-(3-hydroxy-3-methylcyclobutyl)-6-{[6-(trifluoromethyl)pyridin-3-yl]oxy}quinoline-2-carboxamide;
N-[1-(dimethylamino)-1-oxopropan-2-yl]-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-(3,3-difluorocyclobutyl)-6-{[5-(difluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
[(3R)-3-hydroxypiperidin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
[(3S)-3-hydroxypiperidin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
[(3R,4R)-4-amino-3-fluoropiperidin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
N-[(3R,4R)-3-fluoropiperidin-4-yl]-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
(6-{[5-(difluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)[(3S)-3-(hydroxymethyl)piperazin-1-yl]methanone;
{3-[(3S)-3-fluoropyrrolidin-1-yl]azetidin-1-yl}(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
N-(1-methyl-2-oxopyrrolidin-3-yl)-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
[(3R)-3-methoxypyrrolidin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
[(3S)-3-methoxypyrrolidin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
N-(2-methoxypropyl)-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-[(1-methoxycyclobutyl)methyl]-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
6-{[5-(difluoromethyl)pyridin-2-yl]oxy}-N-(3-oxocyclobutyl)quinoline-2-carboxamide;
[(3S)-3-(methoxymethyl)piperazin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
[3-(difluoromethyl)piperazin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
N-(3-cyanopropyl)-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-cyclobutyl-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
azetidin-1-yl(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
[2-(trifluoromethyl)piperazin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
N-(3-methoxypropyl)-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-(thietan-3-ylmethyl)-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-[(1-oxidothietan-3-yl)methyl]-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-[(1,1-dioxidothietan-3-yl)methyl]-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
[(2R)-2-(difluoromethyl)piperazin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
N-(3-fluorocyclobutyl)-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-[2-(2-oxo-1,3-oxazolidin-3-yl)ethyl]-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-[2-(pyridin-2-yl)ethyl]-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-[3-(pyridin-2-yl)propyl]-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-[3-(2-oxopyrrolidin-1-yl)propyl]-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-[(5-oxopyrrolidin-3-yl)methyl]-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-(3-acetamido-2-methylpropyl)-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-methyl-N-[2-(methylsulfonyl)ethyl]-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-[4-(methylsulfonyl)butyl]-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-(3-acetamidopropyl)-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
1-[(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)carbonyl]hexahydropyrrolo[1,2-a]pyrimidin-6(2H)-one;
N-[2-(1,1-dioxidothietan-3-yl)ethyl]-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
N-methyl-N-(2,2,2-trifluoroethyl)-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide;
6-{[5-(difluoromethyl)pyridin-2-yl]oxy}-N-(3-fluorocyclobutyl)quinoline-2-carboxamide;
[4-fluoro-4-(methoxymethyl)piperidin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
[3-(2,2-difluoroethoxy)azetidin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
1,1-dimethyl-4-[(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)carbonyl]piperazin-1-ium iodide;
{3-[(2,2,2-trifluoroethyl)amino]azetidin-1-yl}(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone;
N-(2,2-difluoroethyl)-N-methyl-6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxamide; and
7-oxa-2-azaspiro[3.5]non-2-yl(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone.

### Claim 25 (depends on 1)

A pharmaceutical composition comprising a therapeutically effective amount of a compound of claim 1 in combination with a pharmaceutically acceptable carrier.

### Claim 26 (depends on 1)

A method of selectively modulating the effects of pain in a mammal comprising administering an effective amount of a compound of claim 1.

### Claim 27 (depends on 1)

A method of treating a condition or disorder modulated by the voltage-gated sodium channels Nav1.7 and/or Nav1.8 in a mammal comprising administering an effective amount of a compound of claim 1.

### Claim 28 (depends on 27)

The method according to claim 27, wherein the condition or disorder is selected from the group consisting of pain, including osteoarthritis pain, joint pain (knee pain), neuropathic pain, post-surgical pain, low back pain, and diabetic neuropathy, pain during surgery, cancer pain, chemotherapy induced pain, headaches, including cluster headache, tension headache, migraine pain, trigeminal neuralgia, shingles pain, post-herpetic neuralgia, carpal tunnel syndrome, inflammatory pain, pain from rheumatoid arthritis, colitis, pain of interstitial cystitis, visceral pain, pain from kidney stone, pain from gallstone, angina, fibromyalgia, chronic pain syndrome, thalamic pain syndrome, pain from stroke, phantom limb pain, sunburn, radiculopathy, complex regional pain syndrome, HIV sensory neuropathy, central neuropathic pain syndromes, multiple sclerosis pain, Parkinson disease pain, spinal cord injury pain, menstrual pain, toothache, pain from bone metastasis, pain from endometriosis, pain from uterine fibroids, nociceptive pain, hyperalgesia, temporomandibular joint pain, inherited erythromelalgia (IEM), and paroxysmal extreme pain disorder (PEPD).