# US 2016/0355480 A1 · Substituted pyridines and method of use

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- Number: US 2016/0355480 A1
- Document ID: US20160355480A1
- Status: Published application
- Kind: A1
- Application number: 15/164,317
- Filed: 2016-05-25
- Published: 2016-12-08
- Earliest claimed: 2015-06-02
- Assignees: AbbVie S.á.r.l.; Galapagos NV
- Applicants: AbbVie S.á.r.l.; Galapagos NV
- Inventors: Robert J. Altenbach; Marlon D. Cowart; Tom Roger Lisette De Munck; Sébastien Jean Jacques Cédric Dropsit Montovert; Gregory A. Gfesser; Hans Kelgtermans; Sébastien Laurent Xavier Martina; Steven Emiel Van der Plas; Xueqing Wang
- Web page: https://patentgrep.com/patent/US20160355480A1

## CPC

- C07D 213/81: Amides; Imides
- A61K 31/44: Non condensed pyridines; Hydrogenated derivatives thereof
- A61K 31/4427: containing further heterocyclic ring systems
- A61K 31/443: containing a five-membered ring with oxygen as a ring hetero atom
- A61K 31/4439: containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole (nicotine A61K31/465)
- A61K 31/4545: containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
- A61K 31/506: not condensed and containing further heterocyclic rings
- A61K 31/513: having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
- A61K 31/5377: not condensed and containing further heterocyclic rings, e.g. timolol
- A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61P 5/00: Drugs for disorders of the endocrine system
- A61P 11/00: Drugs for disorders of the respiratory system
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C07D 401/06: linked by a carbon chain containing only aliphatic carbon atoms
- C07D 401/12: linked by a chain containing hetero atoms as chain links
- C07D 401/14: containing three or more hetero rings
- C07D 405/12: linked by a chain containing hetero atoms as chain links
- C07D 491/107: with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The invention discloses compounds of Formula I wherein X, R1, R2, and R3 are as defined herein. The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treating cystic fibrosis by administering a compound of the invention.

## Claims

### Claim 1

A compound of Formula I or a pharmaceutically acceptable salt thereof
wherein
X is
H;
halo;
C1-4 alkyl optionally substituted with one or more independently selected halo;
C1-4 alkoxy optionally substituted with one or more independently selected
—OH;
C1-4 alkoxy; or
—NR11AR11B;
—NR12AR12B;
cyclopropyl optionally substituted with one or more independently selected R5 groups;
phenoxy optionally substituted with one or more independently selected R5 groups; or
phenyl optionally substituted with one or more independently selected R5 groups;
R1 is
C1-4 alkyl optionally substituted with one or more independently selected
—OH;
C1-4 alkoxy; or
4-6 membered monocyclic heterocycle comprising 1 or 2 heteroatoms independently selected from the group consisting of O, S, and N;
phenyl optionally substituted with one or more independently selected R4 groups;
N-linked 4-6 membered monocyclic heterocycle comprising 1, 2, or 3 heteroatoms independently selected from the group consisting of N, O, and S, wherein the monocyclic heterocycle is optionally substituted with one or more independently selected R5 groups;
N-linked 4-6 membered monocyclic heterocycle comprising 1, 2, or 3 heteroatoms independently selected from the group consisting of N, O, and S, fused to a phenyl, wherein the monocyclic heterocycle and the phenyl are optionally substituted with one or more independently selected R5 groups;
C3-7 cycloalkyl optionally substituted with one or more independently selected R5 groups; or
—NR6R7;
R2 is
H;
C1-6 alkyl optionally substituted with one or more independently selected
—OH;
halo;
C1-4 alkoxy optionally substituted with one or more independently selected
halo;
C1-4 alkoxy;
C3-7 cycloalkyl optionally substituted with one or more independently selected R5 groups; or
4-6 membered monocyclic heterocycle comprising 1 or 2 heteroatoms independently selected from the group consisting of N, O, and S, wherein the monocyclic heterocycle is optionally substituted with one or more independently selected R5 groups;
—C(═O)NR8aR8b;
C3-7 cycloalkyl optionally substituted with one or more independently selected
—OH;
halo;
C1-4 alkoxy optionally substituted with one or more independently selected halo; or
C1-4 alkyl optionally substituted with one or more independently selected —OH, halo, or C1-4 alkoxy;
4-6 membered monocyclic heterocycle comprising 1 or 2 heteroatoms independently selected from the group consisting of N, O, and S, wherein the monocyclic heterocycle is optionally substituted with one or more independently selected
—OH;
halo;
C1-4 alkoxy optionally substituted with one or more independently selected halo, or
C1-4 alkyl optionally substituted with one or more independently selected halo;
5-6 membered monocyclic heteroaryl comprising 1, 2, or 3 heteroatoms independently selected from the group consisting of O, S, and N, wherein the monocyclic heteroaryl is optionally substituted with one or more independently selected R5 groups; or
phenyl optionally substituted with one or more independently selected R5 groups;
C3-7 cycloalkyl optionally substituted with one or more
—OH;
halo;
C1-4 alkyl optionally substituted with one or more independently selected halo or —OH; or
C1-4 alkoxy optionally substituted with one or more independently selected halo;
4-6 membered monocyclic heterocycle comprising 1 or 2 heteroatoms independently selected from the group consisting of O, S, and N, wherein the monocyclic heterocycle is optionally substituted with one or more
—OH;
halo;
C1-4 alkyl optionally substituted with one or more independently selected halo; or
C1-4 alkoxy optionally substituted with one or more independently selected halo;
4-6 membered monocyclic heterocycle comprising 1 or 2 heteroatoms independently selected from the group consisting of O, S, and N, fused to a phenyl ring, wherein the monocyclic heterocycle and the phenyl are optionally substituted with one or more independently selected R5 groups;
5-11 membered spirocyclic heterocycle comprising 1 or 2 heteroatoms independently selected from the group consisting of O, S, and N, wherein the spirocyclic heterocycle is optionally substituted with one or more independently selected R5 groups;
5-6 membered monocyclic heteroaryl comprising 1, 2, or 3 heteroatoms independently selected from the group consisting of O, S, and N, wherein the monocyclic heteroaryl is optionally substituted with one or more independently selected R5 groups; or
—NHC(═O)R13;
and R3 is H; or
R2 and R3, together with the nitrogen atom to which they are attached form
an azetidine or a pyrrolidine ring, wherein the azetidine and the pyrrolidine are optionally substituted with one or more independently selected R9 groups; or
a 7-11 membered spirocyclic heterocycle comprising one or more heteroatoms independently selected from the group consisting of N, O, and S; wherein the spirocyclic heterocycle is optionally substituted with one or more independently selected R5 groups;
each R4 is independently selected from the group consisting of:
halo;
C1-4 alkyl optionally substituted with one or more independently selected halo; and
C1-4 alkoxy optionally substituted with one or more independently selected halo;
each R5 is independently selected from the group consisting of:
—OH;
halo;
C1-4 alkyl optionally substituted with one or more independently selected
C1-4 alkoxy;
halo; or
—OH; and
C1-4 alkoxy optionally substituted with one or more independently selected halo;
R6 is H, C1-4 alkyl, or C3-7 cycloalkyl wherein the C3-7 cycloalkyl is optionally substituted with one or more independently selected R5 groups;
R7 is
C1-4 alkyl optionally substituted with one or more independently selected halo;
phenyl optionally substituted with one or more independently selected halo;
C1-4 alkyl optionally substituted with one or more independently selected halo; or
C1-4 alkoxy optionally substituted with one or more independently selected halo;
C1-4 alkoxy optionally substituted with one or more independently selected halo; or
4-6 membered monocyclic heterocycle comprising 1 or 2 heteroatoms independently selected from the group consisting of O, S, and N; wherein the monocyclic heterocycle is optionally substituted with one or more independently selected R5 groups;
each R8a and R8b is independently selected from the group consisting of
H;
C1-4 alkyl optionally substituted with one or more independently selected halo; and
C3-7 cycloalkyl optionally substituted with one or more independently selected R5 groups;
each R9 is independently selected from the group consisting of:
—OH;
halo;
—CN;
C1-4 alkyl optionally substituted with one or more independently selected
—OH;
halo; or
C1-4 alkoxy;
C1-4 alkoxy optionally substituted with one or more independently selected halo;
C3-7 cycloalkyl optionally substituted with one or more independently selected R5 groups;
—C(═O)NR10aR10b; and
4-6 membered monocyclic heterocycle comprising 1 or 2 heteroatoms independently selected from the group consisting of O, S, and N, wherein the monocyclic heterocycle is optionally substituted with one or more independently selected R5 groups;
each R10a and R10b is independently selected from the group consisting of H and C1-4 alkyl;
each R11a and R11b is independently selected from the group consisting of
H; and
C1-4 alkyl;
R12a and R12b are independently selected from the group consisting of
H;
C1-4 alkyl; and
C3-7 cycloalkyl; and
R13 is independently C1-4 alkyl optionally substituted with one or more independently selected
—OH;
halo; or
C1-4 alkoxy.

### Claim 2 (depends on 1)

The compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein
R1 is phenyl optionally substituted with one, two, or three independently selected R4 groups.

### Claim 3 (depends on 1)

The compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein
R1 is N-linked 4-6 membered monocyclic heterocycle comprising 1, 2, or 3 heteroatoms independently selected from the group consisting of N, O, and S, wherein the monocyclic heterocycle is optionally substituted with 1, 2, or 3 independently selected R5 groups.

### Claim 4 (depends on 1)

The compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein
R1 is —NR6R7.

### Claim 5 (depends on 1)

The compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein X is H, halo, or unsubstituted cyclopropyl.

### Claim 6 (depends on 1)

The compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein
R2 is C1-6 alkyl optionally substituted with 1, 2, or 3 independently selected
—OH;
fluoro;
C1-4 alkoxy optionally substituted with 1, 2, or 3 independently selected
fluoro;
C1-4 alkoxy;
C3-7 cycloalkyl optionally substituted with 1, 2, or 3 independently selected R5 groups; or
4-6 membered monocyclic heterocycle comprising 1 or 2 heteroatoms independently selected from the group consisting of N, O, and S, wherein the monocyclic heterocycle is optionally substituted with 1, 2, or 3 independently selected R5 groups;
4-6 membered monocyclic heterocycle comprising 1 or 2 heteroatoms independently selected from the group consisting of N, O, and S, wherein the monocyclic heterocycle is optionally substituted with 1, 2, or 3 independently selected
—OH;
fluoro;
C1-4 alkoxy optionally substituted with 1, 2, or 3 fluoro, or
C1-4 alkyl optionally substituted with 1, 2, or 3 fluoro;
or
phenyl optionally substituted with 1, 2, or 3 independently selected R5 groups.

### Claim 7 (depends on 1)

The compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein
R2 is C3-6 alkyl substituted with one or two —OH, and optionally further substituted with 1, 2, or 3 fluoro; or optionally further substituted with one C1-4 alkoxy which is optionally substituted with
1, 2, or 3 fluoro;
one C1-4 alkoxy; or
one C3-7 cycloalkyl optionally substituted with 1, 2, or 3 independently selected R5 groups.

### Claim 8 (depends on 1)

The compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein
R2 is C1-6 alkyl substituted with one substituent wherein the substituent is
—C(═O)NR8aR8b;
C3-7 cycloalkyl optionally substituted with 1, 2, or 3 independently selected
—OH;
fluoro;
C1-4 alkoxy optionally substituted with 1, 2, or 3 fluoro; or
C1-4 alkyl optionally substituted with 1, 2, or 3 independently selected —OH, fluoro, or C1-4 alkoxy;
4-6 membered monocyclic heterocycle comprising 1 or 2 heteroatoms independently selected from the group consisting of N, O, and S, wherein the monocyclic heterocycle is optionally substituted with 1, 2, or 3 independently selected
—OH;
fluoro;
C1-4 alkoxy optionally substituted with 1, 2, or 3 fluoro, or
C1-4 alkyl optionally substituted with 1, 2, or 3 fluoro;
or
5-6 membered monocyclic heteroaryl comprising 1, 2, or 3 heteroatoms independently selected from the group consisting of O, S, and N, wherein the monocyclic heteroaryl is optionally substituted with 1, 2, or 3 independently selected R5 groups.

### Claim 9 (depends on 1)

The compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein
R2 is C3-6 cycloalkyl optionally substituted with 1, 2, or 3 independently selected —OH; fluoro; C1-4 alkyl optionally substituted with 1, 2, or 3 fluoro; or C1-4 alkoxy optionally substituted with 1, 2, or 3 fluoro.

### Claim 10 (depends on 1)

The compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein
R2 is 4-6 membered monocyclic heterocycle comprising 1 or 2 heteroatoms independently selected from the group consisting of O, S, and N, wherein the monocyclic heterocycle is optionally substituted with 1, 2, or 3 independently selected —OH; fluoro; C1-4 alkyl optionally substituted with 1, 2, or 3 fluoro; or C1-4 alkoxy optionally substituted with 1, 2, or 3 fluoro.

### Claim 11 (depends on 1)

The compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein
R2 and R3, together with the nitrogen atom to which they are attached form an azetidine or a pyrrolidine ring, wherein the azetidine and the pyrrolidine are optionally substituted with 1, 2, or 3 independently selected R9 groups.

### Claim 12 (depends on 1)

The compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein
R2 and R3, together with the nitrogen atom to which they are attached form an azetidine ring which is optionally substituted with 1, 2, or 3 independently selected R9 groups.

### Claim 13 (depends on 1)

The compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein
R1 is phenyl optionally substituted with one, two, or three independently selected R4 groups; and
R2 is C1-6 alkyl optionally substituted with 1, 2, or 3 independently selected
—OH;
fluoro;
C1-4 alkoxy optionally substituted with 1, 2, or 3 independently selected
fluoro;
C1-4 alkoxy;
C3-7 cycloalkyl optionally substituted with 1, 2, or 3 independently selected R5 groups; or
4-6 membered monocyclic heterocycle comprising 1 or 2 heteroatoms independently selected from the group consisting of N, O, and S, wherein the monocyclic heterocycle is optionally substituted with 1, 2, or 3 independently selected R5 groups;
4-6 membered monocyclic heterocycle comprising 1 or 2 heteroatoms independently selected from the group consisting of N, O, and S, wherein the monocyclic heterocycle is optionally substituted with 1, 2, or 3 independently selected
—OH;
fluoro;
C1-4 alkoxy optionally substituted with 1, 2, or 3 fluoro, or
C1-4 alkyl optionally substituted with 1, 2, or 3 fluoro;
or
phenyl optionally substituted with 1, 2, or 3 independently selected R5 groups.

### Claim 14 (depends on 1)

The compound of claim 1 or a pharmaceutically acceptable salt thereof,
wherein
R1 is phenyl optionally substituted with one, two, or three independently selected R4 groups; and
R2 is C3-6 alkyl substituted with one or two —OH, and optionally further substituted with 1, 2, or 3 fluoro; or optionally further substituted with one C1-4 alkoxy which is optionally substituted with
1, 2, or 3 fluoro;
one C1-4 alkoxy; or
one C3-7 cycloalkyl optionally substituted with 1, 2, or 3 independently selected
R5 groups.

### Claim 15 (depends on 1)

The compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein
R1 is phenyl optionally substituted with one, two, or three independently selected R4 groups; and
R2 is C1-6 alkyl substituted with one substituent wherein the substituent is
—C(═O)NR8aR8b;
C3-7 cycloalkyl optionally substituted with 1, 2, or 3 independently selected
—OH;
fluoro;
C1-4 alkoxy optionally substituted with 1, 2, or 3 fluoro; or
C1-4 alkyl optionally substituted with 1, 2, or 3 independently selected —OH, fluoro, or C1-4 alkoxy;
4-6 membered monocyclic heterocycle comprising 1 or 2 heteroatoms independently selected from the group consisting of N, O, and S, wherein the monocyclic heterocycle is optionally substituted with 1, 2, or 3 independently selected
—OH;
fluoro;
C1-4 alkoxy optionally substituted with 1, 2, or 3 fluoro, or
C1-4 alkyl optionally substituted with 1, 2, or 3 fluoro;
or
5-6 membered monocyclic heteroaryl comprising 1, 2, or 3 heteroatoms independently selected from the group consisting of O, S, and N, wherein the monocyclic heteroaryl is optionally substituted with 1, 2, or 3 independently selected R5 groups.

### Claim 16 (depends on 1)

The compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein
R1 is phenyl optionally substituted with one, two, or three independently selected R4 groups; and
R2 is C3-6 cycloalkyl optionally substituted with 1, 2, or 3 independently selected —OH; fluoro; C1-4 alkyl optionally substituted with 1, 2, or 3 fluoro; or C1-4 alkoxy optionally substituted with 1, 2, or 3 fluoro.

### Claim 17 (depends on 1)

The compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein
R1 is phenyl optionally substituted with one, two, or three independently selected R4 groups; and
R2 is 4-6 membered monocyclic heterocycle comprising 1 or 2 heteroatoms independently selected from the group consisting of O, S, and N, wherein the monocyclic heterocycle is optionally substituted with 1, 2, or 3 independently selected —OH; fluoro; C1-4 alkyl optionally substituted with 1, 2, or 3 fluoro; or C1-4 alkoxy optionally substituted with 1, 2, or 3 fluoro.

### Claim 18 (depends on 1)

The compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein
R1 is phenyl optionally substituted with one, two, or three independently selected R4 groups; and
R2 and R3, together with the nitrogen atom to which they are attached form an azetidine or a pyrrolidine ring, wherein the azetidine and the pyrrolidine are optionally substituted with 1, 2, or 3 independently selected R9 groups.

### Claim 19 (depends on 1)

The compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein
R1 is N-linked 4-6 membered monocyclic heterocycle comprising 1, 2, or 3 heteroatoms independently selected from the group consisting of N, O, and S, wherein the monocyclic heterocycle is optionally substituted with 1, 2, or 3 independently selected R5 groups; and
R2 is C3-6 alkyl substituted with one —OH and optionally further substituted with 1, 2, or 3 fluoro; or optionally further substituted with one C1-4 alkoxy wherein the C1-4 alkoxy is optionally substituted with 1, 2, or 3 fluoro.

### Claim 20 (depends on 1)

The compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein
R1 is —NR6R7; and
R2 is C3-6 alkyl substituted with one —OH and optionally further substituted with 1, 2, or 3 fluoro; or optionally further substituted with one C1-4 alkoxy wherein the C1-4 alkoxy is optionally substituted with 1, 2, or 3 fluoro.

### Claim 21 (depends on 1)

The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein
R2 and R3 are H.

### Claim 22 (depends on 1)

The compound of claim 1 of Formula I-a, or a pharmaceutically acceptable salt thereof
wherein
n is 0, 1, or 2;
R4A is H, F, CH3, —CH(CH3)2, t-Bu, CF3, —OCH3, —O—CH(CH3)2, or —OCF3;
each R4B is independently F or —OCF3; and
X, R2, and R3, are as set forth in claim 1.

### Claim 23 (depends on 22)

The compound of claim 22 or a pharmaceutically acceptable salt thereof, wherein X is H.

### Claim 24 (depends on 22)

The compound of claim 22 or a pharmaceutically acceptable salt thereof
wherein
n is 0 or 1;
R4A is F, CF3, or —OCF3; and
R4B is F.

### Claim 25 (depends on 22)

The compound of claim 22 or a pharmaceutically acceptable salt thereof wherein
R2 is C3-6 alkyl substituted with one or two —OH, and optionally further substituted with 1, 2, or 3 fluoro; or optionally further substituted with one C1-4 alkoxy which is optionally substituted with
1, 2, or 3 fluoro;
one C1-4 alkoxy; or
one C3-7 cycloalkyl optionally substituted with 1, 2, or 3 independently selected R5 groups.

### Claim 26 (depends on 22)

The compound of claim 22 or a pharmaceutically acceptable salt thereof wherein
R2 is C3-6 alkyl substituted with one —OH, and optionally further substituted with 1, 2, or 3 fluoro or optionally further substituted with one C1-4 alkoxy wherein the C1-4 alkoxy is optionally substituted with one cyclopropyl or 1, 2, or 3 fluoro.

### Claim 27 (depends on 22)

The compound of claim 22 or a pharmaceutically acceptable salt thereof wherein
R2 is C1-6 alkyl substituted with one —C(═O)NR8aR8b wherein R8a and R8b are independently selected from the group consisting of H; C1-4 alkyl optionally substituted with 1, 2, or 3 fluoro; and cyclopropyl optionally substituted with 1, 2, or 3 independently selected R5 groups.

### Claim 28 (depends on 22)

The compound of claim 22 or a pharmaceutically acceptable salt thereof wherein
R2 is C3-6 cycloalkyl optionally substituted with 1 or 2 independently selected fluoro, CH3, CF3, —OH, or —OCH3.

### Claim 29 (depends on 22)

The compound of claim 22 or a pharmaceutically acceptable salt thereof wherein
R2 is oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, azetidinyl, pyrrolidinyl, or piperidinyl; each of which is optionally substituted with 1 or 2 independently selected fluoro, CH3, CF3, —OH, or —OCH3.

### Claim 30 (depends on 22)

The compound of claim 22 or a pharmaceutically acceptable salt thereof wherein
R2 and R3, together with the nitrogen atom to which they are attached form an azetidine ring which is optionally substituted with 1, 2, or 3 independently selected R9 groups.

### Claim 31 (depends on 22)

The compound of claim 22 or a pharmaceutically acceptable salt thereof wherein
R2 is
wherein
RA is H or CH3; and
RB, RC, and RD are H; or
RB, RC, and RD are fluoro; or
RB and RC are H, and RD is C1-4 alkoxy, —OCH2-cyclopropyl, or —OCH2CF3.

### Claim 32 (depends on 31)

The compound of claim 31 or a pharmaceutically acceptable salt thereof
wherein
n is 0 or 1;
R4A is F, CF3, or —OCF3,
RA is H; and
RB, RC, and RD are fluoro; or
RB and RC are H, and RD is —OCH3, —OCH2CH3, —OCH(CH3)2, —OC(CH3)3, —OCH2-cyclopropyl, or —OCH2CF3.

### Claim 33 (depends on 31)

The compound of claim 31 or a pharmaceutically acceptable salt thereof
wherein
X is H;
n is 0; and
R4A is F.

### Claim 34 (depends on 1)

The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein the compound is selected from the group consisting of:
3-amino-N-(2-hydroxy-2-methylpropyl)-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-(3,3,3-trifluoro-2-hydroxy-2-methylpropyl)-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-(2-hydroxy-3-methoxypropyl)-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
(3-amino-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridin-2-yl)(3-hydroxypyrrolidin-1-yl)methanone;
3-amino-N-[(4-hydroxy-1-methylpiperidin-4-yl)methyl]-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-(3,3,3-trifluoro-2-hydroxypropyl)-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-(tetrahydrofuran-2-ylmethyl)-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-(1,4-dioxan-2-ylmethyl)-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-[2-(morpholin-4-yl)ethyl]-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-5-[(4-fluorophenyl)sulfonyl]-N-(2-hydroxy-2-methylpropyl)pyridine-2-carboxamide;
3-amino-N-(2-hydroxy-2-methylpropyl)-5-{[4-(trifluoromethyl)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-(1-hydroxybutan-2-yl)-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-(1-hydroxy-3-methylbutan-2-yl)-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-(2-hydroxyethyl)-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-[(1-hydroxycyclopropyl)methyl]-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-(2-hydroxy-3,3-dimethylbutyl)-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
rac-3-amino-N-[(1R,2R)-2-hydroxycyclohexyl]-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-(3-hydroxy-2,2-dimethylpropyl)-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-5-[(4-fluorophenyl)sulfonyl]-N-(3,3,3-trifluoro-2-hydroxy-2-methylpropyl)pyridine-2-carboxamide;
3-amino-N-[(2R)-2-hydroxypropyl]-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-[(2S)-2-hydroxypropyl]-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-{[1-(hydroxymethyl)cyclopropyl]methyl}-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-{[1-(hydroxymethyl)cyclobutyl]methyl}-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-(3-hydroxy-2-methylpropyl)-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-5-[(4-fluorophenyl)sulfonyl]-N-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]pyridine-2-carboxamide;
3-amino-N-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-5-[(4-fluorophenyl)sulfonyl]-N-(3,3,3-trifluoro-2-hydroxypropyl)pyridine-2-carboxamide;
3-amino-N-[(3-hydroxytetrahydrofuran-3-yl)methyl]-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-[(4-hydroxytetrahydro-2H-pyran-4-yl)methyl]-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-5-[(4-fluorophenyl)sulfonyl]-N-[(1-hydroxycyclopropyl)methyl]pyridine-2-carboxamide;
3-amino-N-[3-(cyclopropylmethoxy)-2-hydroxypropyl]-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
(3-amino-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridin-2-yl)(3-hydroxyazetidin-1-yl)methanone;
rac-3-amino-N-[(3R,4S)-4-hydroxytetrahydro-2H-pyran-3-yl]-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-(4-hydroxy-2,2-dimethylbutyl)-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-[2-hydroxy-2-(tetrahydro-2H-pyran-4-yl)ethyl]-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-5-[(4-fluorophenyl)sulfonyl]-N-[(2R)-3,3,3-trifluoro-2-hydroxypropyl]pyridine-2-carboxamide;
3-amino-N-[(2R)-3,3,3-trifluoro-2-hydroxypropyl]-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-[3-(2-ethoxyethoxy)-2-hydroxypropyl]-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-5-[(3-fluorophenyl)sulfonyl]-N-(2-hydroxy-2-methylpropyl)pyridine-2-carboxamide;
(3-amino-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridin-2-yl)(3,3-difluoroazetidin-1-yl)methanone;
3-amino-N-[2-hydroxy-1-(4-methylphenyl)ethyl]-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
(3-amino-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridin-2-yl)(3-methoxyazetidin-1-yl)methanone;
3-amino-N-[1-(ethylamino)-1-oxopropan-2-yl]-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-(1,3-dihydroxypropan-2-yl)-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-(4-hydroxybutyl)-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-[(2R)-1-hydroxy-4-methylpentan-2-yl]-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-[(2S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl]-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-[2-(ethylamino)-2-oxoethyl]-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-[(2S)-1-amino-3-methyl-1-oxobutan-2-yl]-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-[(2R)-2,3-dihydroxypropyl]-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-(3-hydroxy-3-methylbutyl)-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-(4,4,4-trifluoro-3-hydroxybutyl)-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-[(3S)-3-hydroxybutyl]-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-(3-hydroxy-4-methoxybutyl)-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-(4-amino-4-oxobutan-2-yl)-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
N2-[(3-amino-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridin-2-yl)carbonyl]-L-leucinamide;
3-amino-N-[2-oxo-2-(propan-2-ylamino)ethyl]-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-[2-(cyclopropylamino)-2-oxoethyl]-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
(3-amino-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridin-2-yl)(3,3-dimethylazetidin-1-yl)methanone;
(3-amino-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridin-2-yl)[3-(morpholin-4-yl)azetidin-1-yl]methanone;
1-[(3-amino-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridin-2-yl)carbonyl]azetidine-3-carbonitrile;
1-[(3-amino-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridin-2-yl)carbonyl]-N,N-dimethylazetidine-3-carboxamide;
3-amino-N-[(2R)-3,3,3-trifluoro-2-hydroxypropyl]-5-{[4-(trifluoromethyl)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-5-{[4-(trifluoromethyl)phenyl]sulfonyl}pyridine-2-carboxamide;
(3-amino-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridin-2-yl)(azetidin-1-yl)methanone;
(3-amino-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridin-2-yl)[3-(hydroxymethyl)azetidin-1-yl]methanone;
(3-amino-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridin-2-yl)(3-fluoroazetidin-1-yl)methanone;
(3-amino-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridin-2-yl)(2-oxa-6-azaspiro[3.3]hept-6-yl)methanone;
3-amino-N-[(2R)-2-hydroxy-3-methoxypropyl]-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-[(2R)-2-hydroxy-3-methoxypropyl]-5-{[4-(trifluoromethyl)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-5-{[2-fluoro-4-(trifluoromethoxy)phenyl]sulfonyl}-N-(2-hydroxy-3-methoxypropyl)pyridine-2-carboxamide;
3-amino-5-[(4-fluorophenyl)sulfonyl]-N-(4,4,4-trifluoro-3-hydroxybutyl)pyridine-2-carboxamide;
3-amino-N-[2-hydroxy-2-(tetrahydrofuran-3-yl)ethyl]-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
rac-3-amino-N-[(3R,4S)-4-hydroxytetrahydrofuran-3-yl]-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-(2-hydroxyethyl)-5-{[2-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
(3-amino-5-{[2-(trifluoromethoxy)phenyl]sulfonyl}pyridin-2-yl)(3-hydroxyazetidin-1-yl)methanone;
(3-amino-5-{[2-fluoro-4-(trifluoromethoxy)phenyl]sulfonyl}pyridin-2-yl)(3-hydroxyazetidin-1-yl)methanone;
(3-amino-5-{[2-(trifluoromethoxy)phenyl]sulfonyl}pyridin-2-yl)(3,3-difluoroazetidin-1-yl)methanone;
(3-amino-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridin-2-yl)[3-hydroxy-3-(trifluoromethyl)azetidin-1-yl]methanone;
3-amino-N-(2-hydroxy-3-methoxypropyl)-5-{[2-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-[(2R)-3,3,3-trifluoro-2-hydroxypropyl]-5-{[2-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-[(2S)-2-hydroxypropyl]-5-{[2-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
rac-3-amino-N-[(3R,4S)-4-hydroxytetrahydro-2H-pyran-3-yl]-5-{[2-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-5-[(4,4-difluoropiperidin-1-yl)sulfonyl]-N-(3,3,3-trifluoro-2-hydroxypropyl)pyridine-2-carboxamide;
(3-amino-5-{[2-(trifluoromethoxy)phenyl]sulfonyl}pyridin-2-yl)[3-hydroxy-3-(trifluoromethyl)azetidin-1-yl]methanone;
(3-amino-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridin-2-yl)(3-cyclopropyl-3-hydroxyazetidin-1-yl)methanone;
3-amino-N-(2-hydroxy-4-methylpentyl)-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-(3-ethoxy-2-hydroxypropyl)-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
(3-amino-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridin-2-yl)(3-hydroxy-3-methylazetidin-1-yl)methanone;
3-amino-N-[2-hydroxy-3-(propan-2-yloxy)propyl]-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
(3-amino-5-{[4-(trifluoromethyl)phenyl]sulfonyl}pyridin-2-yl)(3-hydroxy-3-methylazetidin-1-yl)methanone;
3-amino-N-[2-hydroxy-3-(propan-2-yloxy)propyl]-5-{[4-(trifluoromethyl)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-[(2S)-1-amino-1-oxobutan-2-yl]-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-5-[cyclopropyl(methyl)sulfamoyl]-N-(3,3,3-trifluoro-2-hydroxypropyl)pyridine-2-carboxamide;
3-amino-N-(3,3,3-trifluoro-2-hydroxypropyl)-5-{[4-(trifluoromethyl)piperidin-1-yl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-[2-hydroxy-1-(4-methoxyphenyl)ethyl]-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-5-[(3,3-difluoroazetidin-1-yl)sulfonyl]-N-(3,3,3-trifluoro-2-hydroxypropyl)pyridine-2-carboxamide;
3-amino-5-{[2-fluoro-4-(trifluoromethyl)phenyl]sulfonyl}-N-[(2S)-2-hydroxypropyl]pyridine-2-carboxamide;
3-amino-5-{[2-fluoro-4-(trifluoromethyl)phenyl]sulfonyl}-N-[(2R)-2-hydroxy-3-methoxypropyl]pyridine-2-carboxamide;
3-amino-N-[(2S)-2-hydroxypropyl]-5-{[4-(trifluoromethyl)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-[(3R)-tetrahydrofuran-3-ylmethyl]-5-{[4-(trifluoromethyl)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-[(3S)-tetrahydrofuran-3-ylmethyl]-5-{[4-(trifluoromethyl)phenyl]sulfonyl}pyridine-2-carboxamide;
(3-amino-5-{[4-(trifluoromethyl)phenyl]sulfonyl}pyridin-2-yl)(3,3-difluoroazetidin-1-yl)methanone;
3-amino-N-[2-oxo-2-(propan-2-ylamino)ethyl]-5-{[4-(trifluoromethyl)phenyl]sulfonyl}pyridine-2-carboxamide;
(3-amino-5-{[4-(trifluoromethyl)phenyl]sulfonyl}pyridin-2-yl)[3-hydroxy-3-(trifluoromethyl)azetidin-1-yl]methanone;
3-amino-5-{[2-fluoro-4-(trifluoromethyl)phenyl]sulfonyl}-N-[(3R)-tetrahydrofuran-3-ylmethyl]pyridine-2-carboxamide;
3-amino-5-{[2-fluoro-4-(trifluoromethyl)phenyl]sulfonyl}-N-[(2R)-3,3,3-trifluoro-2-hydroxypropyl]pyridine-2-carboxamide;
3-amino-5-[cyclopropyl(2-methoxyethyl)sulfamoyl]-N-(3,3,3-trifluoro-2-hydroxypropyl)pyridine-2-carboxamide;
3-amino-5-(2,3-dihydro-4H-1,4-benzoxazin-4-yl sulfonyl)-N-(3,3,3-trifluoro-2-hydroxypropyl)pyridine-2-carboxamide;
(3-amino-5-{[4-(trifluoromethyl)phenyl]sulfonyl}pyridin-2-yl)(3,3-dimethylazetidin-1-yl)methanone;
(3-amino-5-{[2-fluoro-4-(trifluoromethyl)phenyl]sulfonyl}pyridin-2-yl)(3,3-dimethylazetidin-1-yl)methanone;
(3-amino-5-{[2-fluoro-4-(trifluoromethyl)phenyl]sulfonyl}pyridin-2-yl)[3-hydroxy-3-(trifluoromethyl)azetidin-1-yl]methanone;
3-amino-5-{[2-fluoro-4-(trifluoromethyl)phenyl]sulfonyl}-N-[2-oxo-2-(propan-2-ylamino)ethyl]pyridine-2-carboxamide;
3-amino-5-{[2-fluoro-4-(trifluoromethyl)phenyl]sulfonyl}-N-[(3S)-tetrahydrofuran-3-ylmethyl]pyridine-2-carboxamide;
3-amino-5-{[2-fluoro-4-(trifluoromethoxy)phenyl]sulfonyl}-N-[(3R)-tetrahydrofuran-3-ylmethyl]pyridine-2-carboxamide;
3-amino-5-{[2-fluoro-4-(trifluoromethoxy)phenyl]sulfonyl}-N-[(3S)-tetrahydrofuran-3-ylmethyl]pyridine-2-carboxamide;
3-amino-5-{[2-fluoro-4-(trifluoromethoxy)phenyl]sulfonyl}-N-[(2R)-3,3,3-trifluoro-2-hydroxypropyl]pyridine-2-carboxamide;
3-amino-N-{[1-(ethoxymethyl)cyclobutyl]methyl}-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
(3-amino-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridin-2-yl)[3-(2,2-difluoroethoxy)azetidin-1-yl]methanone;
3-amino-N-(trans-3-methoxycyclobutyl)-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
(3-amino-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridin-2-yl)(6-oxa-2-azaspiro[3.5]non-2-yl)methanone;
3-amino-N-(3,3-difluorocyclobutyl)-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-(3-methoxypropyl)-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-[2-(1-methylcyclopropyl)ethyl]-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
(3-amino-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridin-2-yl)(6-oxa-2-azaspiro[3.4]oct-2-yl)methanone;
(3-amino-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridin-2-yl)(3-methylazetidin-1-yl)methanone;
3-amino-N-(tetrahydrofuran-3-yl)-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-[(3R)-tetrahydrofuran-3-yl]-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-(tetrahydro-2H-pyran-4-ylmethyl)-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
(3-amino-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridin-2-yl)(3-ethyl-3-fluoroazetidin-1-yl)methanone;
3-amino-N-[3-(cyclopropylmethoxy)-2-hydroxypropyl]-5-{[4-(trifluoromethyl)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-[3-(cyclopropylmethoxy)-2-hydroxypropyl]-5-{[2-fluoro-4-(trifluoromethyl)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-5-{[2-fluoro-4-(trifluoromethyl)phenyl]sulfonyl}-N-[2-hydroxy-3-(propan-2-yloxy)propyl]pyridine-2-carboxamide;
(3-amino-5-{[2-fluoro-4-(trifluoromethoxy)phenyl]sulfonyl}pyridin-2-yl)(3,3-dimethylazetidin-1-yl)methanone;
3-amino-5-{[2-fluoro-4-(trifluoromethoxy)phenyl]sulfonyl}-N-[2-oxo-2-(propan-2-ylamino)ethyl]pyridine-2-carboxamide;
3-amino-5-[(3,4-difluorobenzyl)(methyl)sulfamoyl]-N-(3,3,3-trifluoro-2-hydroxypropyl)pyridine-2-carboxamide;
3-amino-5-[(2,4-difluorobenzyl)(methyl)sulfamoyl]-N-(3,3,3-trifluoro-2-hydroxypropyl)pyridine-2-carboxamide;
3-amino-5-[(4-methoxybenzyl)(methyl)sulfamoyl]-N-(3,3,3-trifluoro-2-hydroxypropyl)pyridine-2-carboxamide;
3-amino-5-(morpholin-4-yl sulfonyl)-N-(3,3,3-trifluoro-2-hydroxypropyl)pyridine-2-carboxamide;
3-amino-N-[(3R)-tetrahydro-2H-pyran-3-yl]-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-[2-(furan-2-yl)ethyl]-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-[(2S)-1-hydroxybutan-2-yl]-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-(tetrahydro-2H-pyran-3-ylmethyl)-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-[(3S)-tetrahydrofuran-3-yl]-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-[(4R)-3,4-dihydro-2H-chromen-4-yl]-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-(tetrahydro-2H-pyran-4-yl)-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-[2-(1,3-dioxolan-2-yl)ethyl]-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-[(2S)-1-hydroxy-3-methylbutan-2-yl]-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-(1-oxaspiro[4.5]dec-3-yl)-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-(1-oxaspiro[4.4]non-3-yl)-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-(oxetan-3-yl)-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-(2-cyclopropylethyl)-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-[(3,3-difluorocyclobutyl)methyl]-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
(3-amino-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridin-2-yl)[3-(methoxymethyl)-3-methylazetidin-1-yl]methanone;
3-amino-N-(cyclopropylmethyl)-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-[(4-methyltetrahydro-2H-pyran-3-yl)methyl]-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
(3-amino-5-{[4-(trifluoromethyl)phenyl]sulfonyl}pyridin-2-yl)[3-(trifluoromethyl)azetidin-1-yl]methanone;
(3-amino-5-{[4-(trifluoromethyl)phenyl]sulfonyl}pyridin-2-yl)[3-(difluoromethoxy)azetidin-1-yl]methanone;
(3-amino-5-{[4-(trifluoromethyl)phenyl]sulfonyl}pyridin-2-yl)[3-hydroxy-3-(propan-2-yl)azetidin-1-yl]methanone;
(3-amino-5-{[2-fluoro-4-(trifluoromethyl)phenyl]sulfonyl}pyridin-2-yl)[3-(trifluoromethyl)azetidin-1-yl]methanone;
(3-amino-5-{[2-fluoro-4-(trifluoromethyl)phenyl]sulfonyl}pyridin-2-yl)[3-(difluoromethoxy)azetidin-1-yl]methanone;
(3-amino-5-{[2-fluoro-4-(trifluoromethyl)phenyl]sulfonyl}pyridin-2-yl)[3-hydroxy-3-(propan-2-yl)azetidin-1-yl]methanone;
3-amino-5-{[2-fluoro-4-(trifluoromethyl)phenyl]sulfonyl}-N-(2-hydroxy-4-methoxy-2-methylbutyl)pyridine-2-carboxamide;
(3-amino-5-{[2-fluoro-4-(trifluoromethyl)phenyl]sulfonyl}pyridin-2-yl)(3,3-difluoroazetidin-1-yl)methanone;
(3-amino-5-{[4-(trifluoromethyl)phenyl]sulfonyl}pyridin-2-yl)[3-(2-hydroxypropan-2-yl)azetidin-1-yl]methanone;
3-amino-N-[2-hydroxy-3-(2-methylpropoxy)propyl]-5-{[4-(trifluoromethyl)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-(2-hydroxy-4-methoxy-2-methylbutyl)-5-{[4-(trifluoromethyl)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-5-{[2-fluoro-4-(trifluoromethoxy)phenyl]sulfonyl}-N-[2-hydroxy-3-(propan-2-yloxy)propyl]pyridine-2-carboxamide;
3-amino-N-[3-(cyclopropylmethoxy)-2-hydroxypropyl]-5-{[2-fluoro-4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-5-{[2-fluoro-4-(trifluoromethyl)phenyl]sulfonyl}-N-[2-hydroxy-3-(2-methylpropoxy)propyl]pyridine-2-carboxamide;
3-amino-5-{[2-fluoro-4-(trifluoromethoxy)phenyl]sulfonyl}-N-[2-hydroxy-3-(2-methylpropoxy)propyl]pyridine-2-carboxamide;
(3-amino-5-{[2-fluoro-4-(trifluoromethoxy)phenyl]sulfonyl}pyridin-2-yl)(3,3-difluoroazetidin-1-yl)methanone;
(3-amino-5-{[2-fluoro-4-(trifluoromethoxy)phenyl]sulfonyl}pyridin-2-yl)[3-hydroxy-3-(trifluoromethyl)azetidin-1-yl]methanone;
(3-amino-5-{[2-fluoro-4-(trifluoromethoxy)phenyl]sulfonyl}pyridin-2-yl)[3-(2-hydroxypropan-2-yl)azetidin-1-yl]methanone;
(3-amino-5-{[2-fluoro-4-(trifluoromethoxy)phenyl]sulfonyl}pyridin-2-yl)[3-hydroxy-3-(propan-2-yl)azetidin-1-yl]methanone;
{3-amino-5-[(4-fluorophenyl)sulfonyl]pyridin-2-yl}[3-hydroxy-3-(trifluoromethyl)azetidin-1-yl]methanone;
3-amino-N-[(2R)-2-hydroxy-3-methoxypropyl]-5-{[2-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
(3-amino-5-{[2-fluoro-4-(trifluoromethyl)phenyl]sulfonyl}pyridin-2-yl)[3-(2-hydroxypropan-2-yl)azetidin-1-yl]methanone;
3-amino-5-{[(2R)-2-methylpyrrolidin-1-yl]sulfonyl}-N-(3,3,3-trifluoro-2-hydroxypropyl)pyridine-2-carboxamide;
3-amino-5-{[(3S)-3-fluoropyrrolidin-1-yl]sulfonyl}-N-(3,3,3-trifluoro-2-hydroxypropyl)pyridine-2-carboxamide;
3-amino-5-{[(2S)-2-methylpyrrolidin-1-yl]sulfonyl}-N-(3,3,3-trifluoro-2-hydroxypropyl)pyridine-2-carboxamide;
3-amino-5-[(3-methylpiperidin-1-yl)sulfonyl]-N-(3,3,3-trifluoro-2-hydroxypropyl)pyridine-2-carboxamide;
3-amino-5-[(3,3-difluoropiperidin-1-yl)sulfonyl]-N-(3,3,3-trifluoro-2-hydroxypropyl)pyridine-2-carboxamide;
3-amino-5-[(4-methylpiperidin-1-yl)sulfonyl]-N-(3,3,3-trifluoro-2-hydroxypropyl)pyridine-2-carboxamide;
3-amino-5-[(3,5-dimethylpiperidin-1-yl)sulfonyl]-N-(3,3,3-trifluoro-2-hydroxypropyl)pyridine-2-carboxamide;
3-amino-5-[(3,3-difluoropyrrolidin-1-yl)sulfonyl]-N-(3,3,3-trifluoro-2-hydroxypropyl)pyridine-2-carboxamide;
3-amino-5-[(4-fluorobenzyl)(methyl)sulfamoyl]-N-(3,3,3-trifluoro-2-hydroxypropyl)pyridine-2-carboxamide;
3-amino-N-(3-methylbutan-2-yl)-5-{[4-(trifluoromethyl)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-(2-methylpropyl)-5-{[4-(trifluoromethyl)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-[2-(tetrahydrofuran-2-ylmethoxy)ethyl]-5-{[4-(trifluoromethyl)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-(2,2-dimethylpropyl)-5-{[4-(trifluoromethyl)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-[2-(propan-2-yloxy)ethyl]-5-{[4-(trifluoromethyl)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}-N-[4-(trifluoromethyl)tetrahydro-2H-pyran-4-yl]pyridine-2-carboxamide;
3-amino-5-[(3-fluoropiperidin-1-yl)sulfonyl]-N-(3,3,3-trifluoro-2-hydroxypropyl)pyridine-2-carboxamide;
3-amino-5-[(4-fluoropiperidin-1-yl)sulfonyl]-N-(3,3,3-trifluoro-2-hydroxypropyl)pyridine-2-carboxamide;
3-amino-5-[(4-methoxypiperidin-1-yl)sulfonyl]-N-(3,3,3-trifluoro-2-hydroxypropyl)pyridine-2-carboxamide;
3-amino-5-[(4-tert-butylpiperidin-1-yl)sulfonyl]-N-(3,3,3-trifluoro-2-hydroxypropyl)pyridine-2-carboxamide;
3-amino-N-(3,3,3-trifluoro-2-hydroxypropyl)-5-{[4-(trifluoromethoxy)piperidin-1-yl]sulfonyl}pyridine-2-carboxamide;
3-amino-5-[(3,3-dimethylazetidin-1-yl)sulfonyl]-N-(3,3,3-trifluoro-2-hydroxypropyl)pyridine-2-carboxamide;
3-amino-5-{[(3R)-tetrahydrofuran-3-ylmethyl]sulfamoyl}-N-(3,3,3-trifluoro-2-hydroxypropyl)pyridine-2-carboxamide;
3-amino-N-[2-hydroxy-3-(2,2,2-trifluoroethoxy)propyl]-5-{[4-(trifluoromethyl)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-(2-methoxyethyl)-5-{[4-(trifluoromethyl)phenyl]sulfonyl}pyridine-2-carboxamide;
(3-amino-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridin-2-yl)(3,3-difluoropyrrolidin-1-yl)methanone;
(3-amino-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridin-2-yl) [(3R)-3-fluoropyrrolidin-1-yl]methanone;
3-amino-N-[(1R,2S)-2-hydroxycyclopentyl]-5-{[4-(trifluoromethyl)phenyl]sulfonyl}pyridine-2-carboxamide;
(3-amino-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridin-2-yl)[(3S)-3-fluoropyrrolidin-1-yl]methanone;
3-amino-N-[(3S)-1-methylpyrrolidin-3-yl]-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-[(3R)-1-methylpyrrolidin-3-yl]-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-(2,2,2-trifluoroethyl)-5-{[4-(trifluoromethyl)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-(1-methylazetidin-3-yl)-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-5-{methyl[4-(trifluoromethyl)benzyl]sulfamoyl}-N-(3,3,3-trifluoro-2-hydroxypropyl)pyridine-2-carboxamide;
3-amino-5-{[4-(trifluoromethyl)phenyl]sulfonyl}-N-(3,3,3-trifluoropropyl)pyridine-2-carboxamide;
3-amino-5-{[2-fluoro-4-(trifluoromethyl)phenyl]sulfonyl}-N-[2-hydroxy-3-(2,2,2-trifluoroethoxy)propyl]pyridine-2-carboxamide;
3-amino-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}-N-[3-(trifluoromethyl)oxetan-3-yl]pyridine-2-carboxamide;
3-amino-N-[(1S,2S)-2-hydroxycyclopentyl]-5-{[4-(trifluoromethyl)phenyl]sulfonyl}pyridine-2-carboxamide;
rac-3-amino-N-[(3R,4S)-4-hydroxytetrahydro-2H-pyran-3-yl]-5-{[4-(trifluoromethyl)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-(2-hydroxyethyl)-5-{[4-(trifluoromethyl)phenyl]sulfonyl}pyridine-2-carboxamide;
rac-3-amino-5-{[2-fluoro-4-(trifluoromethyl)phenyl]sulfonyl}-N-[(3R,4S)-4-hydroxytetrahydro-2H-pyran-3-yl]pyridine-2-carboxamide;
3-amino-5-{[2-fluoro-4-(trifluoromethyl)phenyl]sulfonyl}-N-(2-hydroxyethyl)pyridine-2-carboxamide;
3-amino-5-[(4-methoxyphenyl)sulfonyl]-N-(3,3,3-trifluoro-2-hydroxypropyl)pyridine-2-carboxamide;
3-amino-N-[2-hydroxy-3-(2-methoxyethoxy)propyl]-5-{[4-(trifluoromethyl)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-(3-methoxypropyl)-5-{[4-(trifluoromethyl)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-(cyclopropylmethyl)-5-{[4-(trifluoromethyl)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-(3-tert-butoxy-2-hydroxypropyl)-5-{[2-fluoro-4-(trifluoromethyl)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-5-[methyl(3,3,3-trifluoropropyl)sulfamoyl]-N-(3,3,3-trifluoro-2-hydroxypropyl)pyridine-2-carboxamide;
(3-amino-5-{[4-(trifluoromethyl)phenyl]sulfonyl}pyridin-2-yl)[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]methanone;
3-amino-N-(1-hydroxy-2-methylpropan-2-yl)-5-{[4-(trifluoromethyl)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-[(1-hydroxycyclopropyl)methyl]-5-{[4-(trifluoromethyl)phenyl]sulfonyl}pyridine-2-carboxamide;
(3-amino-5-{[4-(trifluoromethyl)phenyl]sulfonyl}pyridin-2-yl)[(3R,4R)-3,4-dihydroxypyrrolidin-1-yl]methanone;
3-amino-N-[(4-hydroxy-1-methylpiperidin-4-yl)methyl]-5-{[4-(trifluoromethyl)phenyl]sulfonyl}pyridine-2-carboxamide;
(3-amino-5-{[4-(trifluoromethyl)phenyl]sulfonyl}pyridin-2-yl)[3-(2,2-difluoroethoxy)azetidin-1-yl]methanone;
(3-amino-5-{[4-(trifluoromethyl)phenyl]sulfonyl}pyridin-2-yl)[3-(methoxymethyl)-3-methylazetidin-1-yl]methanone;
(3-amino-5-{[4-(trifluoromethyl)phenyl]sulfonyl}pyridin-2-yl) [(2R)-2-(hydroxymethyl)pyrrolidin-1-yl]methanone;
3-amino-N-[(2S)-1-hydroxybutan-2-yl]-5-{[4-(trifluoromethyl)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-[(3R,4S)-4-hydroxytetrahydro-2H-pyran-3-yl]-5-{[4-(trifluoromethyl)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-(3,3,3-trifluoro-2-hydroxypropyl)-5-{[3-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-5-{[4-(propan-2-yloxy)phenyl]sulfonyl}-N-(3,3,3-trifluoro-2-hydroxypropyl)pyridine-2-carboxamide;
3-amino-5-[(tetrahydrofuran-2-ylmethyl)sulfonyl]-N-(3,3,3-trifluoro-2-hydroxypropyl)pyridine-2-carboxamide;
3-amino-N-(2-hydroxy-3-methoxypropyl)-5-{[4-(trifluoromethyl)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-[2-(trifluoromethoxy)ethyl]-5-{[4-(trifluoromethyl)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-(2,2-difluoro-3-hydroxypropyl)-5-{[4-(trifluoromethyl)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-[(2S)-3-(cyclopropylmethoxy)-2-hydroxypropyl]-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-[(2S)-2-hydroxy-3-(propan-2-yloxy)propyl]-5-{[4-(trifluoromethyl)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-5-(phenyl sulfonyl)-N-(3,3,3-trifluoro-2-hydroxypropyl)pyridine-2-carboxamide;
3-amino-5-[(4-methylphenyl)sulfonyl]-N-(3,3,3-trifluoro-2-hydroxypropyl)pyridine-2-carboxamide;
3-amino-5-{[4-(propan-2-yl)phenyl]sulfonyl}-N-(3,3,3-trifluoro-2-hydroxypropyl)pyridine-2-carboxamide;
3-amino-5-[(4-tert-butylphenyl)sulfonyl]-N-(3,3,3-trifluoro-2-hydroxypropyl)pyridine-2-carboxamide;
3-amino-N-[(2R)-2-hydroxy-3-(2,2,2-trifluoroethoxy)propyl]-5-{[4-(trifluoromethyl)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-[(2S)-2-hydroxy-3-(2,2,2-trifluoroethoxy)propyl]-5-{[4-(trifluoromethyl)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-6-bromo-5-[(4-fluorophenyl)sulfonyl]-N-[(2R)-3,3,3-trifluoro-2-hydroxypropyl]pyridine-2-carboxamide;
3-amino-N-[(2R)-3-(cyclopropylmethoxy)-2-hydroxypropyl]-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-[(2R)-2-hydroxy-3-(propan-2-yloxy)propyl]-5-{[4-(trifluoromethyl)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-5-(phenylsulfonyl)-N-[(2R)-3,3,3-trifluoro-2-hydroxypropyl]pyridine-2-carboxamide;
3-amino-5-[(3-fluorophenyl)sulfonyl]-N-[(2R)-3,3,3-trifluoro-2-hydroxypropyl]pyridine-2-carboxamide;
[3-amino-5-(phenylsulfonyl)pyridin-2-yl][3-hydroxy-3-(trifluoromethyl)azetidin-1-yl]methanone;
{3-amino-5-[(3-fluorophenyl)sulfonyl]pyridin-2-yl}[3-hydroxy-3-(trifluoromethyl)azetidin-1-yl]methanone;
3-amino-N-[(3S,4R)-4-hydroxytetrahydro-2H-pyran-3-yl]-5-{[4-(trifluoromethyl)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-6-cyclopropyl-N-(2-hydroxyethyl)-5-{[4-(trifluoromethyl)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-6-(4-fluorophenyl)-5-[(4-fluorophenyl)sulfonyl]-N-[(2R)-3,3,3-trifluoro-2-hydroxypropyl]pyridine-2-carboxamide;
3-amino-6-cyclopropyl-N-(2-hydroxyethyl)-5-(phenylsulfonyl)pyridine-2-carboxamide;
3-amino-5-(cyclopentylsulfonyl)-6-(4-fluorophenyl)-N-[(2S)-2-hydroxypropyl]pyridine-2-carboxamide;
3-amino-6-(4-fluorophenyl)-5-[(2-hydroxyethyl)sulfonyl]-N-[(2S)-2-hydroxypropyl]pyridine-2-carboxamide;
3-amino-5-(ethyl sulfonyl)-6-(4-fluorophenyl)-N-[(2S)-2-hydroxypropyl]pyridine-2-carboxamide;
3-amino-6-(4-fluorophenyl)-N-[(2S)-2-hydroxypropyl]-5-(propan-2-ylsulfonyl)pyridine-2-carboxamide;
3-amino-6-(4-fluorophenyl)-N-[(2S)-2-hydroxypropyl]-5-[(2-methoxyethyl)sulfonyl]pyridine-2-carboxamide;
3-amino-N-[(2S)-2-hydroxypropyl]-5-{[(2S)-2-methylpyrrolidin-1-yl]sulfonyl}pyridine-2-carboxamide;
3-amino-5-[(4-fluorobenzyl)sulfamoyl]-N-[(2S)-2-hydroxypropyl]pyridine-2-carboxamide;
3-amino-5-{[2-(hydroxymethyl)pyrrolidin-1-yl]sulfonyl}-N-[(2S)-2-hydroxypropyl]pyridine-2-carboxamide;
3-amino-5-[(4-fluorobenzyl)(methyl)sulfamoyl]-N-[(2S)-2-hydroxypropyl]pyridine-2-carboxamide;
3-amino-5-{[(2S)-2-methylpyrrolidin-1-yl]sulfonyl}-N-[2-oxo-2-(propan-2-ylamino)ethyl]pyridine-2-carboxamide;
1-[(3-amino-5-{[(2S)-2-methylpyrrolidin-1-yl]sulfonyl}pyridin-2-yl)carbonyl]azetidine-3-carboxamide;
(3-amino-5-{[(2S)-2-methylpyrrolidin-1-yl]sulfonyl}pyridin-2-yl)(3-hydroxyazetidin-1-yl)methanone;
3-amino-N-(3-fluoro-2-hydroxypropyl)-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-6-cyclopropyl-5-[(4-fluorophenyl)sulfonyl]-N-[(2S)-2-hydroxypropyl]pyridine-2-carboxamide;
3-amino-6-cyclopropyl-5-(ethylsulfonyl)-N-[(2S)-2-hydroxypropyl]pyridine-2-carboxamide;
3-amino-N-(2-hydroxy-3-methoxypropyl)-5-{[(2S)-2-methylpyrrolidin-1-yl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-[(2S)-2-hydroxypropyl]-5-[(2-methoxyethyl)(methyl)sulfamoyl]pyridine-2-carboxamide;
3-amino-5-[cyclobutyl(methyl)sulfamoyl]-N-[(2S)-2-hydroxypropyl]pyridine-2-carboxamide;
3-amino-N-(3,3-difluoro-2-hydroxypropyl)-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-[(2S)-2-hydroxypropyl]-6-methoxy-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-[(4-methoxypyrimidin-2-yl)methyl]-5-{[(2S)-2-methylpyrrolidin-1-yl]sulfonyl}pyridine-2-carboxamide;
3-amino-5-{[(2S)-2-methylpyrrolidin-1-yl]sulfonyl}-N-[(6-oxo-1,6-dihydropyrimidin-2-yl)methyl]pyridine-2-carboxamide;
3-amino-6-(dimethylamino)-N-[(2S)-2-hydroxypropyl]-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-6-(3-fluorophenoxy)-N-[(2S)-2-hydroxypropyl]-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-6-(cyclopropylamino)-N-[(2S)-2-hydroxypropyl]-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-(methoxyacetyl)-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carbohydrazide;
3-amino-N-(hydroxyacetyl)-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carbohydrazide;
3-amino-N-[(2S)-2-hydroxypropyl]-6-(2-methoxyethoxy)-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-6-[2-(dimethylamino)ethoxy]-N-[(2S)-2-hydroxypropyl]-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-6-cyclopropyl-N-[(2S)-2-hydroxypropyl]-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-(1H-pyrazol-3-yl)-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-[1-(hydroxymethyl)cyclopropyl]-5-{[4-(trifluoromethyl)phenyl]sulfonyl}pyridine-2-carboxamide;
3-amino-N-[(1S,2S)-2-methoxycyclopentyl]-5-{[4-(trifluoromethyl)phenyl]sulfonyl}pyridine-2-carboxamide;
(3-amino-5-{[4-(trifluoromethyl)phenyl]sulfonyl}pyridin-2-yl)(3-fluoro-3-methylazetidin-1-yl)methanone;
(3-amino-5-{[4-(trifluoromethyl)phenyl]sulfonyl}pyridin-2-yl)(6-oxa-2-azaspiro[3.5]non-2-yl)methanone;
3-amino-N-[(2R)-2-hydroxy-3-methoxypropyl]-5-(phenylsulfonyl)pyridine-2-carboxamide;
3-amino-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}pyridine-2-carboxamide; and
3-amino-6-bromo-5-[(4-fluorophenyl)sulfonyl]pyridine-2-carboxamide.

### Claim 35 (depends on 1)

A pharmaceutical composition comprising a therapeutically effective amount of a compound of Formula I according to claim 1, or a pharmaceutically acceptable salt thereof, in combination with a pharmaceutically acceptable carrier.

### Claim 36 (depends on 1, 34)

A compound of claim 1 or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition of claim 34, for use in medicine.

### Claim 37 (depends on 1, 34)

A compound of claim 1 or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition of claim 34, for use in the treatment of cystic fibrosis.

### Claim 38 (depends on 1)

A method for treating cystic fibrosis in a subject comprising administering a therapeutically effective amount of a compound of Formula I according to claim 1, or a pharmaceutically acceptable salt thereof, to a subject in need thereof.

### Claim 39 (depends on 1)

A pharmaceutical composition comprising a compound of claim 1, or a pharmaceutically acceptable salt thereof, and one or more correctors.

### Claim 40 (depends on 1)

A method for treating cystic fibrosis in a subject comprising administering a compound of claim 1 or a pharmaceutically acceptable salt thereof, and one or more correctors, to a subject in need thereof.

### Claim 41 (depends on 1)

A pharmaceutical composition comprising a compound of claim 1 or a pharmaceutically acceptable salt thereof, and one or more additional therapeutic agents.

### Claim 42 (depends on 41)

The pharmaceutical composition of claim 41 wherein the additional therapeutic agents are selected from the group consisting of CFTR modulators and CFTR amplifiers.

### Claim 43 (depends on 41)

The pharmaceutical composition of claim 41 wherein the additional therapeutic agents are CFTR modulators.

### Claim 44 (depends on 1)

A method for treating cystic fibrosis in a subject comprising administering a compound of claim 1 or a pharmaceutically acceptable salt thereof, and one or more additional therapeutic agents.

### Claim 45 (depends on 44)

The method of claim 44 wherein the additional therapeutic agents are selected from the group consisting of CFTR modulators and CFTR amplifiers.

### Claim 46 (depends on 44)

The method of claim 44 the wherein the additional therapeutic agents are CFTR modulators.