# US 2016/0354541 A1 · Intervertebral dosing device and method > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2016/0354541 A1 - Document ID: US20160354541A1 - Status: Published application - Kind: A1 - Application number: 15/239,997 - Filed: 2016-08-18 - Published: 2016-12-08 - Earliest claimed: 2013-09-18 - Assignees: Globus Medical, Inc. - Applicants: Globus Medical, Inc. - Inventors: Neil R. Crawford; Nicholas Theodore; Mitchell A. Foster - Web page: https://patentgrep.com/patent/US20160354541A1 ## CPC - A61M 5/16804: {Active flow controllers} - A61B 17/3403: {Needle locating or guiding means} - A61B 17/3472: {for bones, e.g. intraosseus injections} - A61B 17/864: {hollow, e.g. with socket or cannulated} - A61M 5/16813: {by controlling the degree of opening of the flow line} - A61M 39/0208: {Subcutaneous access sites (implantable infusion devices A61M5/14276; transcutaneous access sites A61M39/0247)} - A61M 39/24: Check- or non-return valves - A61B 2017/00261: {Discectomy} - A61B 2017/00743: {Type of operation; Specification of treatment sites (A61B2017/00238 takes precedence)} - A61M 2039/2486: {Guided stem, e.g. reciprocating stopper} - A61M 2210/02: Bones - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) ## Abstract Some embodiments of the invention include a cannulated bone screw including a screw shaft with screw thread, a proximal end, a distal end, and a channel extending through the screw shaft. Some embodiments include an inlet port coupled to the channel and extending through the distal end, and an outlet port coupled to the channel by a curved or angled channel region. In some embodiments, the outlet port extends through the screw shaft and exits a side that is substantially parallel to the shaft longitudinal axis. In some embodiments, the cannulated bone screw can form part of a therapy delivery device. In some embodiments, the outlet port extends through a portion of the screw shaft and exits at the distal end. In some embodiments, the valve includes a plunger with a plunger rod within the screw shaft, and a valve seat for control of fluid flow out of the screw. ## Claims ### Claim 1 A cannulated bone screw comprising: a screw shaft including a screw thread and a longitudinal axis, wherein the longitudinal axis extends from a proximal end of the screw shaft to a distal end of the screw shaft; a first channel extending from the proximal end towards the distal end; a first inlet port fluidly coupled to the first channel and extending through the proximal end; and a first outlet port fluidly coupled to the first channel, wherein the outlet port is configured to exit a side of the screw shaft. ### Claim 2 (depends on 1) The cannulated bone screw of claim 1, wherein at least a portion of the first channel is substantially parallel to the longitudinal axis; ### Claim 3 (depends on 1) The cannulated bone screw of claim 1, wherein at least some portion of the first channel is substantially perpendicular to the longitudinal axis. ### Claim 4 (depends on 1) The cannulated bone screw of claim 1, wherein the first channel bends to connect to the outlet port. ### Claim 5 (depends on 1) The cannulated bone screw of claim 1, wherein the first outlet port is at the distal end of the screw shaft. ### Claim 6 (depends on 1) The cannulated bone screw of claim 1, wherein the diameter of the first inlet port is substantially the same as the diameter of the first output port. ### Claim 7 (depends on 1) The cannulated bone screw of claim 1, wherein the diameter of the first inlet port is different from the first outlet port. ### Claim 8 (depends on 1) The cannulated bone screw of claim 1, wherein the diameter of the first inlet port and the diameter of the first outlet port are different from the diameter of the first channel. ### Claim 9 (depends on 1) The cannulated bone screw of claim 1, further comprising a second inlet port in communication with the first channel. ### Claim 10 (depends on 1) The cannulated bone screw of claim 1, further comprising a second outlet port in communication with the first channel. ### Claim 11 (depends on 1) The cannulated bone screw of claim 1, further comprising a second channel fluidly isolated from the first channel. ### Claim 12 (depends on 1) The cannulated bone screw of claim 1, wherein the first outlet port is configured to allow dose delivery to an intervertebral disc. ### Claim 13 (depends on 1) The cannulated bone screw of claim 1, further comprising a temporary encasement at least partially covering the screw. ### Claim 14 (depends on 13) The cannulated bone screw of claim 13, wherein the temporary encasement envelops substantially all the screw thread. ### Claim 15 (depends on 13) The cannulated bone screw of claim 13, wherein the temporary encasement comprises wax. ### Claim 16 A cannulated bone screw comprising: a screw shaft including a screw thread, a proximal end, and a distal end including a tip; at least one channel extending through the screw shaft wherein at least a portion of the at least one channel is substantially parallel to the longitudinal axis of the screw shaft; at least one inlet port fluidly coupled to the at least one channel and extending through the proximal end; and at least one outlet port fluidly coupled to the at least one channel by a curved or angled channel region, the at least one outlet port exiting at least one side of the screw that is substantially parallel to the longitudinal axis of the screw shaft. ### Claim 17 (depends on 16) The cannulated bone screw of claim 16, further comprising a temporary encasement at least partially covering the screw. ### Claim 18 (depends on 17) The cannulated bone screw of claim 17, wherein the temporary encasement envelops substantially all the screw thread. ### Claim 19 (depends on 18) The cannulated bone screw of claim 18, wherein the temporary encasement comprises wax. ### Claim 20 (depends on 16) The cannulated bone screw of claim 16, wherein the at least one output port is configured to allow dose delivery to an intervertebral disc.