# US 2016/0354533 A1 · Adsorbing pathogen-inactivating compounds with porous particles immobilized in a matrix

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- Number: US 2016/0354533 A1
- Document ID: US20160354533A1
- Status: Published application
- Kind: A1
- Application number: 14/991,831
- Filed: 2016-01-08
- Published: 2016-12-08
- Earliest claimed: 1998-01-06
- Assignees: Cerus Corporation
- Applicants: Cerus Corporation
- Inventors: Derek J. HEI
- Web page: https://patentgrep.com/patent/US20160354533A1

## CPC

- A61M 1/3679: {by absorption (A61M1/3675 takes precedence)}
- A01N 1/124: Disinfecting agents, e.g. antimicrobials
- A01N 1/128: Chemically defined matrices for immobilising, holding or storing living parts, e.g. alginate gels; Chemically altering living parts, e.g. by cross-linking
- A61K 35/18: Erythrocytes (haemoglobin A61K38/42)
- A61L 2/00: Disinfection or sterilisation of materials or objects, in general; Accessories therefor
- A61L 2/16: using chemical substances
- A61M 1/0209: {Multiple bag systems for separating or storing blood components}
- A61M 1/0218: {with filters}
- A61M 1/3616: {Batch-type treatment}
- A61M 1/3686: {by removing photoactive agents after irradiation}
- B01J 20/20: comprising free carbon; comprising carbon obtained by carbonising processes
- B01J 20/26: Synthetic macromolecular compounds
- B01J 20/261: {obtained by reactions only involving carbon to carbon unsaturated bonds (macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds per se C08F)}
- B01J 20/28004: {Sorbent size or size distribution, e.g. particle size}
- B01J 20/28014: {characterised by their form}
- B01J 20/28019: {Spherical, ellipsoidal or cylindrical}
- B01J 20/28026: {Particles within, immobilised, dispersed, entrapped in or on a matrix, e.g. a resin}
- B01J 20/28028: {Particles immobilised within fibres or filaments}
- B01J 20/28057: {Surface area, e.g. B.E.T specific surface area}
- B01J 20/28064: {being in the range 500-1000 m2/g}
- B01J 20/28066: {being more than 1000 m2/g}
- B01J 20/28078: {Pore diameter}
- B01J 20/28083: {being in the range 2-50 nm, i.e. mesopores}
- B01J 20/28085: {being more than 50 nm, i.e. macropores}
- C07D 219/10: attached in position 9
- C07D 405/12: linked by a chain containing hetero atoms as chain links
- C07D 493/04: Ortho-condensed systems
- C07F 9/64: Acridine or hydrogenated acridine ring systems
- A61L 2103/05: Living organisms or biological materials
- A61L 2103/09: Blood or products thereof
- A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)}
- A01N: PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF (preservation of food or foodstuff A23); BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES (preparations for medical, dental or toiletry purposes which kill or prevent the growth or proliferation of unwanted organisms A61K); PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)
- B01J: CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- C07F: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM (metal-containing porphyrins C07D487/22)

## Abstract

Methods and devices are provided for reducing the concentration of low molecular weight compounds in a biological composition containing cells while substantially maintaining a desired biological activity of the biological composition. The device comprises highly porous adsorbent particles, and the adsorbent particles are immobilized by an inert matrix. The matrix containing the particles is contained in a housing, and the particles range in diameter from about 100 μm to about 1500 μm. The device can be used to adsorb and remove a pathogen-inactivating compounds from a biological composition such as a blood product.

## Claims

### Claim 1

A pathogen-inactivating compound adsorption system for reducing the concentration of a low molecular weight pathogen-inactivating compound in an aqueous biological composition containing cellular elements, wherein the pathogen-inactivating compound adsorption system comprises a housing compatible with the biological composition containing an adsorption medium comprising porous adsorbent particles immobilized within a sintered matrix formed from polymeric particulate material, wherein the diameter of the adsorbent particles ranges from about 100 μm to about 1500 μm, wherein the adsorbent particles have an affinity for said pathogen-inactivating compound, wherein the system is configured to remove said pathogen-inactivating compound from said biological composition in a batch process, and wherein the system is configured so that the cellular elements in the biological composition treated with the system maintain sufficient biological activity so that said biological composition is suitable for infusion within a human, the system further comprising a particle retention medium downstream of the adsorption medium, wherein said particle retention medium retains particles shed from said adsorption medium.

### Claim 2 (depends on 1)

A system according to claim 1, wherein the porous adsorbent particles have a surface area greater than about 750 m2/g, and the porous adsorbent particles are between 25 and 85 percent of the weight of the adsorption medium.

### Claim 3 (depends on 2)

A system according to claim 2, wherein the porous adsorbent particles are between 50 and 80 percent of the weight of the adsorption medium, and the adsorption medium has a particle loading of between 100 and 500 g/m2.

### Claim 4 (depends on 3)

A system according to claim 3, wherein the adsorption medium has a particle loading of between 250 and 350 g/m2.

### Claim 5 (depends on 1)

A system according to claim 1, wherein the matrix contains said porous adsorbent particles.

### Claim 6 (depends on 5)

A system according to claim 5, wherein the porous adsorbent particles comprise a synthetic polymeric adsorbent having a porous network structure and having a surface area greater than about 750 m2/g.

### Claim 7 (depends on 5)

A system according to claim 5, wherein the porous adsorbent particles comprise activated carbon.

### Claim 8 (depends on 6)

A system according to claim 6, wherein the porous adsorbent particles comprise a polyaromatic resin.

### Claim 9 (depends on 8)

A system according to claim 8, wherein said resin has a pore size between about 25 and 800 Å.

### Claim 10 (depends on 9)

A system according to claim 9, wherein said resin has a pore size between about 25 and 150 Å.

### Claim 11 (depends on 6)

A system according to claim 6, wherein the porous adsorbent particles do not require prewetting before use.

### Claim 12 (depends on 6)

A system according to claim 6, wherein the porous adsorbent particles comprise a hypercrosslinked resin.

### Claim 13 (depends on 7)

A system according to claim 7, wherein the porous adsorbent particles comprise activated carbon having a surface area between about 1000 and 3000 m2/g.

### Claim 14 (depends on 13)

A system according to claim 13, wherein the activated carbon is derived from a synthetic source and at least about 50% of pores of the activated carbon particles have a diameter less than about 20 Å.

### Claim 15 (depends on 6)

A system according to claim 6, wherein the diameter of the porous adsorbent particles is between about 300 and 900 μm.

### Claim 16 (depends on 7)

A system according to claim 7, wherein the diameter of the porous adsorbent particles is between about 300 and 900 μm.

### Claim 17 (depends on 1)

A system according to claim 1, wherein the pathogen inactivating compound comprises a nucleic acid-binding compound.

### Claim 18 (depends on 17)

A system according to claim 17, wherein the nucleic acid-binding compound comprises a psoralen derivative.

### Claim 19 (depends on 17)

A system according to claim 17, wherein the nucleic acid-binding compound comprises an acridine derivative.

### Claim 20 (depends on 17)

A system according to claim 17, wherein the nucleic acid-binding compound comprises a dye.