# US 2016/0354513 A1 · Method of making water soluble injectable calcium polyphosphate gels > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2016/0354513 A1 - Document ID: US20160354513A1 - Status: Published application - Kind: A1 - Application number: 14/900,835 - Filed: 2014-07-03 - Published: 2016-12-08 - Earliest claimed: 2013-07-03 - Assignees: Wayne State University - Applicants: Wayne State University - Inventors: Weiping Ren; Wei Song - Web page: https://patentgrep.com/patent/US20160354513A1 ## CPC - A61L 27/12: Phosphorus-containing materials, e.g. apatite - A61K 9/1652: {Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin (homeopathic globules A61K9/1623)} - A61K 9/5073: {having two or more different coatings optionally including drug-containing subcoatings} - A61L 27/52: Hydrogels or hydrocolloids - A61L 27/54: Biologically active materials, e.g. therapeutic substances {(A61L27/227 takes precedence)} - A61L 2400/06: Flowable or injectable implant compositions - A61L 2430/02: for reconstruction of bones; weight-bearing implants - A61L 2430/34: for soft tissue reconstruction - A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K) - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) ## Abstract The present invention describes an injectable calcium polyphosphate (CPP) gel with dense structure, which can be applied as injectable bone void filler in medical field, such as orthopedic and dental applications. Amorphous CPP powder with fine particle size (<75 pm) can be completely dissolved in water, forming a homogeneous gelation phase separated from water phase. This homogeneous CPP gel with disentangled inorganic polyphosphate chains shows viscoelasticity and superior adhesion to natural bone, metal implant surfaces and other ceramic material surfaces. The CPP gel is biomimetic and biodegradable with strong osteoconductivity and osteoinductivity. The manufacturing procedure is easy and reproducible. The mechanical strength of CPP gel is controllable by modifications, such as sintering, incorporation of other biomaterials, etc. ## Claims ### Claim at position 1 1-47. (canceled) ### Claim 48 A composition for bone or soft tissue repair, the composition comprising: a colloid, the colloid being injectable and comprising amorphous calcium polyphosphate. ### Claim 49 (depends on 48) The composition according to claim 48, wherein the colloid is water soluble. ### Claim 50 (depends on 48) The composition according to claim 48, wherein the amorphous calcium polyphosphate has a degree of polymerization of about 100. ### Claim 51 (depends on 48) The composition according to claim 48, wherein the composition undergoes gelation after injection, and solidifies after about sixty minutes. ### Claim 52 (depends on 48) The composition according to claim 48, wherein the colloid is formed in an aqueous solution. ### Claim 53 (depends on 48) The composition according to claim 48, further comprising a drug to be released after injection of the composition. ### Claim 54 (depends on 48) The composition according to claim 48, wherein the drug is substantially fully released for at least 30 hours after injection. ### Claim 55 (depends on 48) The composition according to claim 48, further comprising at least one of a metal, an organic compound, a polymer, and an inorganic ceramic material. ### Claim 56 (depends on 48) The composition according to claim 48, further comprising a quantity of crystalline calcium polyphosphate to form a composite colloid. ### Claim 57 (depends on 56) The composition according to claim 56 having a ratio of amorphous calcium polyphosphate to crystalline calcium polyphosphate between about 1:1 to about 10:1. ### Claim 58 (depends on 57) The composition according to claim 57, wherein the ratio of amorphous calcium polyphosphate to crystalline calcium polyphosphate is about 2:1. ### Claim 59 (depends on 56) The composition according to claim 56, wherein the composite colloid is formed in an aqueous solution. ### Claim 60 (depends on 56) The composition according to claim 56, wherein composite colloid comprises crystals of calcium polyphosphate dispersed therein. ### Claim 61 (depends on 56) The composition according to claim 56, wherein the composite colloid sets to a solid within about 200 seconds when dried at about 37 degrees Celsius. ### Claim 62 (depends on 56) The composition according to claim 56, further comprising at least one of a metal, an organic compound, a polymer, and an inorganic ceramic material. ### Claim 63 (depends on 56) The composition according to claim 56, further comprising a drug to be released after injection of the composition, the drug being substantially fully released for at least 150 hours after injection. ### Claim 64 A composition for bone or soft tissue repair, the composition comprising: a colloid, the colloid being an injectable composite colloid comprising amorphous calcium polyphosphate and crystalline calcium polyphosphate in a predetermined ratio, the composite colloid being water soluble. ### Claim 65 (depends on 64) The composition according to claim 64, wherein the predetermined ratio of amorphous calcium polyphosphate is between about 1:1 and about 10:1. ### Claim 66 (depends on 64) The composition according to claim 64 having a ratio of amorphous calcium polyphosphate:crystalline calcium polyphosphate:water of about 2:1:20. ### Claim 67 (depends on 64) The composition according to claim 64, wherein the composition has a porous structure after solidifying and setting.