# US 2016/0354471 A1 · Pine Bark Extract and Black Pepper Essential Oil with Anti-Inflammatory and Anti-Arthritic Action and Method of Preparing

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- Number: US 2016/0354471 A1
- Document ID: US20160354471A1
- Status: Published application
- Kind: A1
- Application number: 14/731,097
- Filed: 2015-06-04
- Published: 2016-12-08
- Earliest claimed: 2015-06-04
- Inventors: Antonino Cavallaro
- Web page: https://patentgrep.com/patent/US20160354471A1

## CPC

- A61K 47/32: Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers {, poly(meth)acrylates, or polyvinyl pyrrolidone}
- A61K 9/0014: {Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00)}
- A61K 9/06: Ointments; Bases therefor; {Other semi-solid forms, e.g. creams, sticks, gels (composition of ointments, creams or gels A61K47/00)}
- A61K 31/355: Tocopherols, e.g. vitamin E
- A61K 36/15: Pinaceae (Pine family), e.g. pine or cedar
- A61K 36/67: Piperaceae (Pepper family), e.g. Jamaican pepper or kava
- A61K 47/10: Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A61K 47/183: {Amino acids, e.g. glycine, EDTA or aspartame}
- A61K 2300/00: Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

A gel for topical application, comprising of: about 37.0 percent by weight of deionized water; about 0.3 percent by weight of acrylate crosspolymer; about 0.05 percent by weight of glycerin; about 0.2 percent by weight of tocopherol acetate; about 0.15 percent by weight of pine bark extract; about 2.0 percent by weight of black pepper essential oil; about 60.0 percent by weight of isopropyl alcohol SDA; about 0.1 percent by weight of ethylenediamine tetraacetic acid; and, about 2.0 percent by weight of a preservative mixture solution comprising 3 percent by weight of propylparaben, 11 percent by weight of methylparaben and 30 percent by weight of diazolinyl urea.

## Claims

### Claim 1

A gel for topical application, comprising of:
about 37.0 percent by weight of deionized water;
about 0.3 percent by weight of acrylate crosspolymer;
about 0.05 percent by weight of glycerin;
about 0.2 percent by weight of tocopherol acetate;
about 0.15 percent by weight of pine bark extract;
about 2.0 percent by weight of black pepper essential oil;
about 60.0 percent by weight of isopropyl alcohol SDA;
about 0.1 percent by weight of ethylenediamine tetraacetic acid; and,
about 2.0 percent by weight of a preservative mixture solution comprising 3 percent by weight of propylparaben, 11 percent by weight of methylparaben and 30 percent by weight of diazolinyl urea.

### Claim 2

A method for preparing a gel, comprising the steps of:
sprinkling acrylate crosspolymer on a surface of deionized water on a surface of deionized water;
mixing acrylate crosspolymer on a surface of deionized water and the deionized water;
dissolving isopropyl alcohol SDA in the acrylate crosspolymer and deionized water and mixing;
adding the following ingredients: glycerin, tocopherol acetate, pine bark extract, black pepper essential oil, a preservative mixture solution comprising propylparaben, methylparaben and diazolinyl urea and mixing;
wherein aforementioned ingredients are added to said gel in the following quantities:
about 37.0 grams of deionized water;
about 0.3 grams of acrylate crosspolymer;
about 0.05 grams of glycerin;
about 0.2 grams of tocopherol acetate;
about 0.15 grams of pine bark extract;
about 2.0 grams of black pepper essential oil;
about 60.0 grams of isopropyl alcohol SDA;
about 0.1 grams of ethylenediamine tetraacetic acid; and,
about 2.0 grams of a preservative mixture solution comprising about 0.06 grams of propylparaben, 0.22 grams of methylparaben and 0.6 grams of diazolinyl urea.

### Claim 3

A method for treating topical inflammation, comprising the steps of:
periodically applying said gel topically to a patient's skin, wherein the gel comprises:
about 37.0 percent by weight of deionized water;
about 0.3 percent by weight of acrylate crosspolymer;
about 0.05 percent by weight of glycerin;
about 0.2 percent by weight of tocopherol acetate;
about 0.15 percent by weight of pine bark extract;
about 2.0 percent by weight of black pepper essential oil;
about 60.0 percent by weight of isopropyl alcohol SDA;
about 0.1 percent by weight of ethylenediamine tetraacetic acid; and,
about 2.0 percent by weight of a preservative mixture solution comprising 3 percent by weight of propylparaben, 11 percent by weight of methylparaben and 30 percent by weight of diazolinyl urea.